The influence of ischemic bowel wall damage on translocation, inflammatory response, and clinical course

Schoeffel, Ulrich; Baumgartner, Ulrich; Imdahl, A.; Haering, R; Specht, Bernd-Ulrich von; Farthmann, E. H.

doi:10.1016/s0002-9610(97)00048-2

Cited by 9 publications

(6 citation statements)

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“…Short-term mortality of patients with NOMI was reported in 22 studies, and 7 of these analyse the outcome of surgery (online supplemental figure 3). 22 25 27 31–33 35 38 39 42 48 49 93 154–162 The overall mortality of NOMI independent of treatment was 58.4% (95% CI 48.6 to 67.7) and was similar in the studies including operated patients.…”

Section: Resultssupporting

confidence: 59%

“…The overall mortality was 59.6% (95% CI 55.5 to 63.6) and was only slightly lower in sub-analysis of the 33 studies, which included patients who had been operated on (figure 4). 19 24 27 33 35 36 40 41 43 47 51 58 92–111 Short-term mortality was 51.7% (95% CI 37.5 to 65.5) in prospective (n=9)32 39 49 60 78 82 87 89 112 and 62.9% (95% CI 56.5 to 68.8) in retrospective (n=37)17 25 26 28 37 42 45 48 50 57 62–77 79–81 83–86 88 90 91 studies (p=0.15). Table 1 illustrates the evolution of mortality over time.…”

Section: Resultsmentioning

confidence: 98%

“…Thirty-eight studies reported the proportions of different forms of AMI in their cohorts 14 17 21–56. Quantitative analysis demonstrates that the most common form is occlusive arterial, constituting 68.6% (95% CI 63.7 to 73.2) of all AMI cases (online supplemental figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…In total, 81 studies were included in meta-analysis of short-term mortality of AMI, defined as either in-hospital or within 30-days 17 19 22 24–28 32–37 39–43 45 47–52 56–58 60 62–112. The overall mortality was 59.6% (95% CI 55.5 to 63.6) and was only slightly lower in sub-analysis of the 33 studies, which included patients who had been operated on (figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…Sixty-one studies addressed the short-term mortality of occlusive arterial AMI 6 22 25 27 31–35 38 39 42 48 49 59 62 63 66 94 95 97 113–153. Meta-analysis showed an overall mortality of 51.8% (95% CI 46.3 to 57.3) (online supplemental figure 2).…”

Section: Resultsmentioning

confidence: 99%

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Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis

et al. 2022

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ObjectiveTo estimate the incidence of acute mesenteric ischaemia (AMI), proportions of its different forms and short-term and long-term mortality.DesignSystematic review and meta-analysis.Data sourcesMEDLINE (Ovid), Web of Science, Scopus and Cochrane Library were searched until 26 July 2022.Eligibility criteriaStudies reporting data on the incidence and outcomes of AMI in adult populations.Data extraction and synthesisData extraction and quality assessment with modified Newcastle-Ottawa scale were performed using predeveloped standard forms. The outcomes were the incidence of AMI and its different forms in the general population and in patients admitted to hospital, and the mortality of AMI in its different forms.ResultsFrom 3064 records, 335 full texts were reviewed and 163 included in the quantitative analysis. The mean incidence of AMI was 6.2 (95% CI 1.9 to 12.9) per 100 000 person years. On average 5.0 (95% CI 3.3 to 7.1) of 10 000 hospital admissions were due to AMI. Occlusive arterial AMI was the most common form constituting 68.6% (95% CI 63.7 to 73.2) of all AMI cases, with similar proportions of embolism and thrombosis.Overall short-term mortality (in-hospital or within 30 days) of AMI was 59.6% (95% CI 55.5 to 63.6), being 68.7% (95% CI 60.8 to 74.9) in patients treated before the year 2000 and 55.0% (95% CI 45.5 to 64.1) in patients treated from 2000 onwards (p<0.05). The mid/long-term mortality of AMI was 68.2% (95% CI 60.7 to 74.9). Mortality due to mesenteric venous thrombosis was 24.6% (95% CI 17.0 to 32.9) and of non-occlusive mesenteric ischaemia 58.4% (95% CI 48.6 to 67.7). The short-term mortality of revascularised occlusive arterial AMI was 33.9% (95% CI 30.7 to 37.4).ConclusionsIn adult patients, AMI is a rarely diagnosed condition with high mortality, although with improvement of treatment results over the last decades. Two thirds of AMI cases are of occlusive arterial origin with potential for better survival if revascularised.PROSPERO registration numberCRD42021247148.

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Section: Resultssupporting

confidence: 59%