The influence of Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-17, TNF-A, MIF, STAT3 on lung cancer risk in Moroccan population

Kaanane, Houda; Senhaji, Nezha; Berradi, Hind; Benchakroun, Nadia; Benider, Abdellatif; Karkouri, Mehdi; Attar, H. El; Flores, Orfeu; Khyatti, Meriem; Nadifi, Sellama

doi:10.1016/j.cyto.2022.155806

“…(Table 2). Consequently, our results confirmed the findings observed in previous reports (De Vita et al, 1998;Songür et al, 2004;Koh et al, 2012;Siagian et al, 2021;Kaanane et al, 2022).…”

Section: Resultssupporting

confidence: 94%

Assessment of iron status markers in patients with lung cancer

Jasim

¹

,

Hadi

²

2022

ijhs

0

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Lung cancer is one of the most diagnosed diseases in men and women and is the leading cause of cancer-related mortality worldwide. The purpose of this study is to examine the impact of lung cancer on the role of iron status markers in patient serum. The present study included fifty (50) lung cancer patients (males and females) and forty (40) healthy subjects. The levels of iron status markers that include iron, ferritin, transferrin, transferrin saturation (TS%), total iron binding capacity (TIBC), and unsaturated iron binding capacity (UIBC) were estimated in the serum of lung cancer patients, as well as the value of interleukin 6 (IL-6) were recorded. Generally, the results of the present study revealed significant differences (p<0.05) in the levels of iron status markers and IL-6 in the serum of lung cancer patients in comparison with the control groups. The findings of this study suggest that these indicators play an important role in lung cancer at multiple levels and that the specific activity of these biomarkers may be relevant as an independent predictor of lung cancer disease progression.

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“…(Table 2). Consequently, our results confirmed the findings observed in previous reports (De Vita et al, 1998;Songür et al, 2004;Koh et al, 2012;Siagian et al, 2021;Kaanane et al, 2022). The IL-6 is a well-documented cytokine that has a significant role in numerous chronic inflammatory disorders (Kang et al, 2020).…”

Section: Resultssupporting

confidence: 93%

Assessment of iron status markers in patients with lung cancer

Jasim

¹

,

Hadi

²

2022

ijhs

0

View full text Add to dashboard Cite

Lung cancer is one of the most diagnosed diseases in men and women and is the leading cause of cancer-related mortality worldwide. The purpose of this study is to examine the impact of lung cancer on the role of iron status markers in patient serum. The present study included fifty (50) lung cancer patients (males and females) and forty (40) healthy subjects. The levels of iron status markers that include iron, ferritin, transferrin, transferrin saturation (TS%), total iron binding capacity (TIBC), and unsaturated iron binding capacity (UIBC) were estimated in the serum of lung cancer patients, as well as the value of interleukin 6 (IL-6) were recorded. Generally, the results of the present study revealed significant differences (p<0.05) in the levels of iron status markers and IL-6 in the serum of lung cancer patients in comparison with the control groups. The findings of this study suggest that these indicators play an important role in lung cancer at multiple levels and that the specific activity of these biomarkers may be relevant as an independent predictor of lung cancer disease progression.

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“…The classification of cytokines as inflammatory (released by Th-1 T helper cells) or anti-inflammatory (released by Th-2 T helper cells) is a frequent practice ( 12 ). The pathogenesis of cancer, particularly lung cancer, is thought to be significantly influenced by specific inflammatory cytokines, according to numerous research published to date ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Zhao

¹

,

Jia²,

Zhang³

2023

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Lung cancer is one of the most prevalent cancer types and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cancer incidences. Lung cancer therapy and prognosis largely depend on the disease’s degree at the diagnosis time. Cytokines are soluble polypeptides that contribute to cell-to-cell communication, acting paracrine or autocrine on neighboring or distant cells. Cytokines are essential for developing neoplastic growth, but they are also known to operate as biological inducers following cancer therapy. Early indications are that inflammatory cytokines such as IL-6 and IL-8 play a predictive role in lung cancer. Nevertheless, the biological significance of cytokine levels in lung cancer has not yet been investigated. This review aimed to assess the existing literature on serum cytokine levels and additional factors as potential immunotherapeutic targets and lung cancer prognostic indicators. Changes in serum cytokine levels have been identified as immunological biomarkers for lung cancer and predict the effectiveness of targeted immunotherapy.

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The influence of Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-17, TNF-A, MIF, STAT3 on lung cancer risk in Moroccan population

Cited by 15 publications

References 39 publications

Assessment of iron status markers in patients with lung cancer

Assessment of iron status markers in patients with lung cancer

Assessment of iron status markers in patients with lung cancer

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

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