The Influence of Interleukin-2 Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma

Mousa, Somaia Mohammed; Makhlouf, Manal Mohamed; Mohammed, Ekhlass Talaat; Zawam, Hamdy

doi:10.1007/s12288-020-01388-4

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…31 Besides, the TG/GG of rs2069762 in IL-2 increased the risk of non-Hodgkin's lymphoma by more than three times, and was more likely to develop adverse outcomes. 20 In our results, we found that a total of eight SNPs contributed to lymphoma susceptibility under at least one genetic model, which were significantly different between lymphoma patients and healthy controls. These SNPs include cytokines (IFNL3, TNFA, IL4), genes of JAK-STAT and NF-κB pathways (STAT3, STAT5B, NFKBIA), and PARP1 which plays an important role in DNA repair and apoptosis.…”

Section: Genementioning

confidence: 50%

“…For example, IL‐10 polymorphisms were reported to be associated with the risk of lymphoma, 10 and rs1800871‐CC may play a pathogenic role in the occurrence of non‐Hodgkin's lymphoma 31 . Besides, the TG/GG of rs2069762 in IL‐2 increased the risk of non‐Hodgkin's lymphoma by more than three times, and was more likely to develop adverse outcomes 20 . In our results, we found that a total of eight SNPs contributed to lymphoma susceptibility under at least one genetic model, which were significantly different between lymphoma patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…To deeply discover new markers related to the etiology, progression and prognosis of lymphoma, we used the Agena Massarray technology platform to detect 25 candidate SNPs of 21 genes (TNFA, IFNG, IFNL3, IL2, IL4, IL6R, IL9, IL10, IL12A, IL22, TGFB1, TBX21/TBET, STAT1, STAT3, STAT5B, STAT6, GATA3, NFKBIA, ITGAM, PTPN22, PARP1) in 245 lymphoma patients and 213 healthy controls 8,10,16–57 . All the 25 candidate SNPs were based on previous research studies about immune‐related genetic polymorphisms on the susceptibility, prognosis, progression and stage of many cancers.…”

Section: Introductionmentioning

confidence: 99%

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The genetic polymorphisms of immune‐related genes contribute to the susceptibility and survival of lymphoma

Can

Liu

et al. 2023

Cancer Medicine

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BackgroundThough immunological abnormalities have been proven involved in the pathogenesis of lymphoma, the underlying mechanism remains unclear.MethodsWe investigated 25 single nucleotide polymorphisms (SNPs) of 21 immune‐related genes and explored their roles in lymphoma. The genotyping assay of the selected SNPs was used by the Massarray platform. Logistic regression and Cox proportional hazards models were used to analyze the associations of SNPs and the susceptibility of lymphoma or clinical characteristics of lymphoma patients. In addition, Least Absolute Shrinkage and Selection Operator regression was used to further analyze the relationships with the survival of lymphoma patients and candidate SNPs, and the significant difference between genotypes was verified by the expression of RNA.ResultsBy comparing 245 lymphoma patients with 213 healthy controls, we found eight important SNPs related to the susceptibility of lymphoma, which were involved in JAK–STAT, NF‐κB and other functional pathways. We further analyzed the relationships between SNPs and clinical characteristics. Our results showed that both IL6R (rs2228145) and STAT5B (rs6503691) significantly contributed to the Ann Arbor stages of lymphoma. And the STAT3 (rs744166), IL2 (rs2069762), IL10 (rs1800871), and PARP1 (rs907187) manifested a significant relationship with the peripheral blood counts in lymphoma patients. More importantly, the IFNG (rs2069718) and IL12A (rs6887695) were associated with the overall survival (OS) of lymphoma patients remarkably, and the adverse effects of GC genotypes could not be offset by Bonferroni correction for multiple comparison in rs6887695 especially. Moreover, we determined that the mRNA expression levels of IFNG and IL12A were significantly decreased in patients with shorter‐OS genotypes.ConclusionsWe used multiple methods of analysis to predict the correlations between lymphoma susceptibility, clinical characteristics or OS with SNPs. Our findings reveal that immune‐related genetic polymorphisms contribute to the prognosis and treatment of lymphoma, which may serve as promising predictive targets.

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Section: Genementioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The genetic polymorphisms of immune‐related genes contribute to the susceptibility and survival of lymphoma

Can

Liu

et al. 2023

Cancer Medicine

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“…Data have shown that this variant is involved in increased susceptibility to nasopharyngeal [ 26 ] and oral cancer [ 27 ], and literature data have shown that this variant was associated with gastric cancer [ 28 ] and breast cancer [ 6 ]. A study from 2021 confirmed that the IL2 gene variants rs2069762 and rs2069763 could be involved in the development of non-Hodgkin lymphoma (NHL) [ 29 ]. On the other hand, a meta-analysis from 2015 indicated that the variant IL2 rs2069762 was not associated with cancer risk [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Selected Single-Nucleotide Variants in Patients with Neuroendocrine Tumors—Potential Clinical Relevance

Kurzyńska

Pach

Skalniak

et al. 2022

JCM

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Introduction: The genetic basis of neuroendocrine tumors (NETs), whose incidence is continuously increasing, is still not fully defined. The majority of NETs are sporadic, and only a small percentage occur as part of hereditary genetic syndromes. However, the associations of multiple genetic variants have been found as clinically relevant in several neoplasms. The aim of this study was to evaluate whether selected, literature-based genetic variants may have a potential role in NET susceptibility and clinical outcome in Polish patients. Materials/methods: A total of 185 patients recruited from one clinical center were enrolled. In the first part of the study, the molecular analysis including four single-nucleotide variants (rs8005354 (DAD1, NM_001344 intronic T/C substitution), rs2069762 (T/G substitution in the promoter region of the IL2 NM_000586), rs3731198 (CDKN2A, NM_000077 intronic A/G substitution), and rs1800872 (C/A substitution in the promoter region of the IL10 NM_000572)) was performed in 107 participants (49 patients with NETs with different primary site NETs and a control group of 58 healthy adult volunteers). In the second stage, the same single-nucleotide polymorphisms (SNPs) were assessed in 127 patients with NET and analyzed in terms of clinical data (primary site, serum CgA concentration, and metastatic disease). Results: The analysis of homozygotes revealed a statistically significant higher prevalence of TT homozygotes of variant rs3731198 in the control group (p = 0.0209). In NET patients, there was a statistically significant higher prevalence of GG homozygotes of variant rs1800872 (p = 0.003). There was a statistically significant correlation between the rs3731198 variant and lymph node metastases (p = 0.0038 with Bonferroni correction). Conclusions: Our study indicates that GG homozygotes of variant rs1800872 are more often observed in NET patients, while TT homozygotes of variant rs3731198 are less frequent in this group. The rs3731198 variant may be related to an increased risk of lymph node metastasis. Further, larger multicenter studies are warranted to evaluate the potential genetic factors of sporadic NETs.

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“…State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. Patients were divided into four groups: complete remission (CR), partial remission (PR), stable disease (SD), and progression disease (PD) 32 . Patients with complete and partial remission were classified as the overall response group, while patients with stable disease and progression disease were classified as the ineffective group 33 .…”

Section: Methodsmentioning

confidence: 99%

A model to predict the prognosis of diffuse large B-cell lymphoma based on ultrasound images

Chen

Zhou

et al. 2023

Sci Rep

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The purpose of this paper was to assess the value of ultrasonography in the prognosis of diffuse large b-cell lymphoma (DLBCL) by developing a new prognostic model. One hundred and eleven DLBCL patients with complete clinical information and ultrasound findings were enrolled in our study. Univariate and multivariate regression analyses were used to identify independent risk factors for progression-free survival (PFS) and overall survival (OS). Receiver operator characteristic (ROC) curves were plotted and the corresponding area under the curve (AUC) was calculated to assess the accuracy of the international prognostic index (IPI) and new model in DLBCL risk stratification. The results suggested that hilum loss and ineffective treatment were independent risk variables for both PFS and OS in DLBCL patients. Additionally, the new model that added hilum loss and ineffective treatment to IPI had a better AUC for PFS and OS than IPI alone (AUC: 0.90, 0.88, and 0.82 vs. 0.71, 0.74, and 0.68 for 1-, 3-, and 5-year PFS, respectively; AUC: 0.92, 0.85 and 0.86 vs. 0.71, 0.75 and 0.76, for 1-, 3-, and 5-year OS, respectively). The model based on ultrasound images could better suggest PFS and OS of DLBCL, allowing for better risk stratification.

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The Influence of Interleukin-2 Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma

Cited by 7 publications

References 23 publications

The genetic polymorphisms of immune‐related genes contribute to the susceptibility and survival of lymphoma

The genetic polymorphisms of immune‐related genes contribute to the susceptibility and survival of lymphoma

Prevalence of Selected Single-Nucleotide Variants in Patients with Neuroendocrine Tumors—Potential Clinical Relevance

A model to predict the prognosis of diffuse large B-cell lymphoma based on ultrasound images

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