The Influence of Hyperosmolality on Left Ventricular Contractile State

Jd, Newell; Higgins, C B; Mj, Kelley; Ce, Green; Ws, Schmidt; Haigler, Frank H.

doi:10.1097/00004424-198009000-00003

Cited by 55 publications

(11 citation statements)

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“…However, ionic hypertonic solfftions have caused a decrease in contractility in the isolated perfused heart [16] while nonionic hypertonic solutions produced a positive inotropic response in canine heart [17]. In our study, hypertonic sucrose solution (equivalent ionic contents plus 15% sucrose) caused a marked depression in contractility without changes in.…”

Section: Discussionmentioning

confidence: 44%

Effects of new intravascular contrast agents on [Ca2+]i transients and contraction in cultured ventricular myocytes

et al. 1992

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We examined the effects of four kinds of intravascular contrast agents (amidtrizoic acid, iohexol, iopamidol, and ioxaglic acid) on [Ca2+]i transients (indo-1 fluorescence) and cell contraction (video motion analyzer), using cultured chick embryo ventricular myocytes. Exposure of ventricular myocytes to amidtrizoic acid (a conventional contrast agent) reduced the [Ca2+]i transients and the sensitivity of the contractile elements to [Ca2+]i. Ioxaglic acid (a low osmotic contrast agent) also reduced the [Ca2+]i transients, but did not significantly change the sensitivity of the contractile elements to [Ca2+]i. Neither iohexol nor iopamidol (nonionic contrast agents) reduced the [Ca2+]i transients, but both significantly decreased the sensitivity of the contractile elements to [Ca2+]i. A marked negative inotropic effect of amidtrizoic acid was caused by both calcium binding and hypertonicity. The less marked depression of contractility produced by ioxaglic acid is possibly the result of calcium binding, but is not caused by hypertonicity. The negative inotropism produced by nonionic contrast agents (iohexol and iopamidol) was due to hypertonicity, but not due to alterations in the [Ca2+]i transients. Exposure of ventricular myocytes to nonionic contrast agents (iohexol and iopamidol) slowed decay in the [Ca2+]i transients with increased end-diastolic [Ca2+]i. After washing out the nonionic contrast agents, these parameters returned to control levels. On the other hand, exposure to amidtrizoic acid decreased end-diastolic [Ca2+]i without changing decay time in the [Ca2+]i transients. After washing out amidtrizoic acid, there was a prolongation of half decay time in [Ca2+]i transients with a significant increase in end-diastolic [Ca2+]i and cell position. Diastolic dysfunction just after washout of amidtrizoic acid was possibly caused by an increase in [Na+]i due to sodium influx during exposure to the contrast agent.

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Section: Discussionmentioning

confidence: 44%

Effects of new intravascular contrast agents on [Ca2+]i transients and contraction in cultured ventricular myocytes

et al. 1992

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“…NEWELL et coll. (8) demonstrated that non-ionic hyperosmolar solutions such as glucose and mannitol had a positive, rather than a negative, inotropic effect and that hyperosmolar sodium chloride solutions caused drastic and progressive deterioration in the myocardial contractile state, and concluded that excess sodium ions was the major factor causing the negative inotropic action of contrast media. THOMSON et coll.…”

Section: Discussionmentioning

confidence: 99%

Effect of Contrast Media on Left Ventricular Function during Left Coronary Arteriography in Dogs

Hayakawa¹,

Yamashita²

1989

Acta Radiol

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The effect of contrast media on the left ventricular function of the heart was assessed by left coronary administration of contrast media using canine models. Following insertion of the catheter into the left coronary artery, 0.5 ml/kg of a test solution was injected at a rate of 1 mVs. The test solutions included isotonic saline, meglumine/sodium diatrizoate, iopamidol and ioxaglate. The mean systemic pressure, left ventricular end-systolic and end-diastolic pressures and the first derivative of left ventricular pressure were continuously measured until five min post-injection. Left ventricular function decreased immediately by 15 s post-injection and recovered quickly by one min. The inhibition of myocardial contractility was observed with diatrizoate and ioxaglate to the same degree. These changes were statistically more pronounced than those with iopamidol, which showed changes similar to those with saline in all parameters except for the positive inotropic effects. These observations suggest that not only hyperosmolality but also ionic composition and chemotoxicity are the factors responsible for the myocardial depression and that no single factor dominates in their effects.

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“…Différents travaux montrent une augmentation de l'inotropisme cardiaque [9][10][11] alors que d'autres concluent à l'absence d'effet du SSH sur la contractilité myocardique [7,[12][13][14]. Ces discordances pourraient s'expliquer par les effets spécifiques de l'apport d'ion sodium et de l'hyperosmolarité.…”

Section: Action Sur Le Débit Cardiaqueunclassified