The influence of human fetal mesenchymal stem cells on glioma cell proliferation. The consequence of cellular crosstalk

Chistiakova, I A; Polianskaia, G G

doi:10.1134/s1990519x15020042

Cited by 5 publications

(5 citation statements)

References 49 publications

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“…They retain the capacity to uptake and deliver therapeutic drugs and can be targeted, for example, via chemical modification to glioblastoma (neuropilin-1) [40]. Chistiakova et al demonstrated effective inhibition of glioblastoma cell growth in vitro using an MSC-derived exosomal conditioned medium (see the review of Do et al for further in vitro and in vivo evidence [40]) [41]. In their review, Lin et al discussed evidence supporting the phenomenon that exosomes derived from MSCs enhance chemosensitivity and reduce resistance of breast cancer cells exposed to cisplatin.…”

Section: Msc-derived Exosomes As Cell Free Targeting Therapeuticsmentioning

confidence: 99%

Micro-Fragmented Adipose Tissue as a Natural Scaffold for Targeted Drug Delivery in Brain Cancer

Salagean,

Nechifor-Boila,

Bajwa

et al. 2023

IJMS

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Major limitations in the effective treatment of neurological cancer include systemic cytotoxicity of chemotherapy, inaccessibility, and inoperability. The capability to successfully target a drug to the tumor site(s) without incurring serious side effects—especially in the case of aggressive tumors, such as glioblastoma and neuroblastoma—would represent a significant breakthrough in therapy. Orthotopic systems, capable of storing and releasing proteins over a prolonged period at the site of a tumor, that utilize nanoparticles, liposomes, and hydrogels have been proposed. One candidate for drug delivery is Micro-Fragmented Adipose Tissue (MFAT). Easily obtained from the patient by abdominal subcutaneous liposuction (autologous), and with a high content of Mesenchymal Stem Cells (MSCs), mechanically derived nanofat is a natural tissue graft with a structural scaffold organization. It has a well-preserved stromal vascular fraction and a prolonged capacity to secrete anti-tumorigenic concentrations of pre-absorbed chemotherapeutics within extracellular vesicles. This review discusses current evidence supporting the potential of drug-modified MFAT for the treatment of neurological cancer with respect to recent preclinical and in vitro studies. Possible limitations and future perspectives are considered.

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Section: Msc-derived Exosomes As Cell Free Targeting Therapeuticsmentioning

confidence: 99%

Micro-Fragmented Adipose Tissue as a Natural Scaffold for Targeted Drug Delivery in Brain Cancer

Salagean,

Nechifor-Boila,

Bajwa

et al. 2023

IJMS

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“…Chistyakova et al observed that CM collected from MSCs exerted no pro-proliferative effect on glioma cells, but those collected from MSCs co-cultured with glioma cells induced proliferation in other glioma cultures. Interestingly, this tumor-supportive effect was only observed when using culture medium harvested within the first 3–9 days of co-culture, while medium collected at later time points (15–21 days) had an inhibitory effect on glioma cell proliferation [ 166 ]. It is important to note that most of the conflicting reports were only conducted in vitro, and most of them used CM, which contained EVs and also a wide range of other complex molecules.…”

Section: Current Status Of Msc-ev Therapeutic Applications In the Brainmentioning

confidence: 99%

Application of Mesenchymal Stem Cells in Targeted Delivery to the Brain: Potential and Challenges of the Extracellular Vesicle-Based Approach for Brain Tumor Treatment

Duy

Kurniawati

Hsieh

et al. 2021

IJMS

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Treating brain tumors presents enormous challenges, and there are still poor prognoses in both adults and children. Application of novel targets and potential drugs is hindered by the function of the blood-brain barrier, which significantly restricts therapeutic access to the tumor. Mesenchymal stem cells (MSCs) can cross biological barriers, migrate to sites of injuries to exert many healing effects, and be engineered to incorporate different types of cargo, making them an ideal vehicle to transport anti-tumor agents to the central nervous system. Extracellular vesicles (EVs) produced by MSCs (MSC-EVs) have valuable innate properties from parent cells, and are being exploited as cell-free treatments for many neurological diseases. Compared to using MSCs, targeted delivery via MSC-EVs has a better pharmacokinetic profile, yet avoids many critical issues of cell-based systems. As the field of MSC therapeutic applications is quickly expanding, this article aims to give an overall picture for one direction of EV-based targeting of brain tumors, with updates on available techniques, outcomes of experimental models, and critical challenges of this concept.

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“…Chistiakova and Polianskaia characterized the paracrine activity of the conditioned medium of fetal MSCs, from both BM and muscle origin, in different spatial and temporal conditions. No molecule presents in the secretome of MSCs affected GBM cell growth, whereas the picture changed after direct coculture: the crosstalk between U251‐MG glioma cell line and fetal MSCs impair cell growth in the early period of co‐cultivation, which turns into cell proliferation after long time of coculture 128 …”

Section: Crosstalk Between Msc and Gbm Cells: Direct And Indirect Intmentioning

confidence: 99%

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

Bajetto

Thellung

Dellacasagrande

et al. 2020

Stem Cells Translational Medicine

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Mesenchymal stem cells (MSCs) can be isolated from bone marrow or other adult tissues (adipose tissue, dental pulp, amniotic fluid, and umbilical cord). In vitro, MSCs grow as adherent cells, display fibroblast-like morphology, and self-renew, undergoing specific mesodermal differentiation. High heterogeneity of MSCs from different origin, and differences in preparation techniques, make difficult to uniform their functional properties for therapeutic purposes. Immunomodulatory, migratory, and differentiation ability, fueled clinical MSC application in regenerative medicine, whereas beneficial effects are currently mainly ascribed to their secretome and extracellular vesicles. MSC translational potential in cancer therapy exploits putative anti-tumor activity and inherent tropism toward tumor sites to deliver cytotoxic drugs. However, controversial results emerged evaluating either the therapeutic potential or homing efficiency of MSCs, as both antitumor and protumor effects were reported. Glioblastoma (GBM) is the most malignant brain tumor and its development and aggressive nature is sustained by cancer stem cells (CSCs) and the identification of effective therapeutic is required. MSC dualistic action, tumor-promoting or tumor-targeting, is dependent on secreted factors and extracellular vesicles driving a complex cross talk between MSCs and GBM CSCs. Tumor-tropic ability of MSCs, besides providing an alternative therapeutic approach, could represent a tool to understand the biology of GBM CSCs and related paracrine mechanisms, underpinning MSC-GBM interactions. In this review, recent findings on the complex nature of MSCs will be highlighted, focusing on their elusive impact on GBM progression and aggressiveness by direct cell-cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.

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The influence of human fetal mesenchymal stem cells on glioma cell proliferation. The consequence of cellular crosstalk

Cited by 5 publications

References 49 publications

Micro-Fragmented Adipose Tissue as a Natural Scaffold for Targeted Drug Delivery in Brain Cancer

Micro-Fragmented Adipose Tissue as a Natural Scaffold for Targeted Drug Delivery in Brain Cancer

Application of Mesenchymal Stem Cells in Targeted Delivery to the Brain: Potential and Challenges of the Extracellular Vesicle-Based Approach for Brain Tumor Treatment

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

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