The influence of host genetics on liver microbiome composition in patients with NAFLD

Pirola, Carlos José; Salatino, Adrián Emanuel; Quintanilla, Maria Florencia; Castaño, Gustavo Osvaldo; Garaycoechea, Martín; Sookoian, Silvia

doi:10.1016/j.ebiom.2022.103858

Cited by 15 publications

(12 citation statements)

References 55 publications

(83 reference statements)

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“…In line with our observation of differences in microbiome functioning, P221-PWY (octane oxidation) was shown to increase with the Westernization of the human gut and lifestyle [81,82] as volatile organic compounds, including octane, were found either in the exhaled air or feces of human subjects with diverse medical conditions associated with oxidative stress and chronic inflammation, including lung cancer [82,83] obstructive sleep apnea [84], gastrointestinal diseases [85] and NAFLD [86]. Previous studies demonstrated that several alkane-degrading bacteria were capable of using diverse compounds as a carbon source in addition to alkanes [87], which are further oxidized to fatty acids via the bacterial β-oxidation pathway (BioCyc ID: P221-PWY).…”

Section: Metabolic Pathways Observed In Human Gutsupporting

confidence: 86%

Urine and Fecal 1H-NMR Metabolomes Differ Significantly between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males

et al. 2022

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Preterm birth (before 37 weeks gestation) accounts for ~10% of births worldwide and remains one of the leading causes of death in children under 5 years of age. Preterm born adults have been consistently shown to be at an increased risk for chronic disorders including cardiovascular, endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease, respiratory infections, and sleep disturbances). The aim of this study was to explore the differences between preterm and full-term male participants’ levels of urine and fecal proton nuclear magnetic resonance (1H-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess general differences in human gut-microbiomes through metagenomics at the level of taxonomy, diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites. Significant differences existed between the two groups based on the analysis of 1H-NMR urine and fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome interactions between the two groups and enabling the efficient classification of samples; however, this could not be directed to specific taxonomic characteristics.

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Section: Metabolic Pathways Observed In Human Gutsupporting

confidence: 86%

Urine and Fecal 1H-NMR Metabolomes Differ Significantly between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males

et al. 2022

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“…The Anaerovoraceae family has been associated with diabetic retinopathy. 81 The Tyzzerella genus has not been characterized per se but is often associated, together with other genera, with inflammation, [82][83][84] poor lifestyles 83,85 and diseases such as type 2 diabetes, 86 cardiovascular disease risk profile, 87 non-alcoholic fatty liver disease 88 and colorectal adenoma. 89 Thus, exposure to Mesosilver™ or AgC can deplete important beneficial bacterial taxa of the gut microbiota and increase the abundance of detrimental ones, although further characterization of identified genera is required.…”

Section: Discussionmentioning

confidence: 99%

Fate, uptake and gut toxicity of two colloidal silver products in mice: how micro X-ray fluorescence, micro X-ray absorption spectroscopy and near-infrared spectroscopy provide new insights in food nanotoxicology

Gillois

Rivard

Bézirard

et al. 2023

Environ. Sci.: Nano

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“…Previous research has shown that Firmicutes , Coriobacteriaceae_UCG-002 , and Romboutsia were positively correlated with the increase of fat and blood lipids ( 31 – 33 ). Tyzzerella has been proven to be related to the consumption of sugar and carbohydrate ( 34 ). Bilophila was reported to be related to fat growth ( 35 ) and Enterorhabdus was associated with diabetes or other metabolic diseases ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium animalis subsp. lactis MN-Gup protects mice against gut microbiota-related obesity and endotoxemia induced by a high fat diet

Niu

Zhang

Li³

et al. 2022

Front. Nutr.

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Obesity has become a public health concern due to its global prevalence and high risk of complications such as endotoxemia. Given the important role of gut microbiota in obesity, probiotics targeting gut microbiota have been developed and applied to alleviate obesity. However, most studies focused on the effects of probiotics on pre-existing obesity, and the preventive effects of probiotics against obesity were rarely studied. This study aimed to investigate the preventive effects of Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and fermented milk containing MN-Gup against high fat diet (HFD)-induced obesity and endotoxemia in C57BL/6J mice. The results showed that MN-Gup, especially the high dose of MN-Gup (1 × 1010CFU/kg b.w.), could significantly protect mice against HFD-induced body weight gain, increased fat percentage, dyslipidemia, and increased lipopolysaccharides (LPS). Fermented milk containing MN-Gup had better preventive effects on fat percentage and dyslipidemia than fermented milk without MN-Gup, but its overall performance was less effective than MN-Gup. Furthermore, MN-Gup and fermented milk containing MN-Gup could alter HFD-affected gut microbiota and regulate obesity- or endotoxemia-correlated bacteria, which may contribute to the prevention of obesity and endotoxemia. This study revealed that MN-Gup could reduce obesity and endotoxemia under HFD, thereby providing a potential application of MN-Gup in preventing obesity.

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The influence of host genetics on liver microbiome composition in patients with NAFLD

Cited by 15 publications

References 55 publications

Urine and Fecal 1H-NMR Metabolomes Differ Significantly between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males

Urine and Fecal 1H-NMR Metabolomes Differ Significantly between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males

Fate, uptake and gut toxicity of two colloidal silver products in mice: how micro X-ray fluorescence, micro X-ray absorption spectroscopy and near-infrared spectroscopy provide new insights in food nanotoxicology

Bifidobacterium animalis subsp. lactis MN-Gup protects mice against gut microbiota-related obesity and endotoxemia induced by a high fat diet

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