The Influence of Hormonal Contraception on Vitamin D Supplementation on Serum 25(OH)D<sub>3</sub> Status in Premenopausal Women: A Prospective Double-Blind Placebo Random Controlled Trial

Wyon, Matthew; Wolman, Roger; Nevill, Alan M.; Barber, Alison E.; Edwards, Marcia; Bowd, Belinda; Clarke, Frances; Bryant, Janine; Cloak, Ross

doi:10.14740/jem441w

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Wyon et al reported a small-scale, prospective, double-blind placebo RCT in which estrogen-containing oral contraceptives increased serum 25(OH)D in premenopausal women, with a magnified effect in women taking vitamin D supplements. 21 Harmon et al reported that estrogen-containing contraceptives were associated with a 20% increase in 25(OH)D concentration in a large study of African American women in one area of northern latitude. 22 Lastly, Ciebiera et al suggested that oral contraceptive use is associated with higher 25(OH)D concentrations in a healthy patient population of premenopausal Caucasian women of northern latitude who were not pregnant or breastfeeding.…”

Section: Discussionmentioning

confidence: 99%

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

Huff,

Schulz,

Richardson

et al. 2023

Am J Perinatol

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Objective This article aims to determine the association between maternal 25-hydroxy-vitamin D [25(OH)D] status and intake of hormonal oral contraceptive pills (OCPs) in women who are lactating. Study Design Women who were exclusively breastfeeding participated in a randomized controlled trial assessing vitamin D supplementation at 400, 2,400, or 6,400 international unit (IU)/d from 1 month through 7 months postpartum. This observational, secondary analysis assessed whether OCPs were associated with maternal 25(OH)D concentrations in women who are lactating. Multivariate regression models were used to predict 25(OH)D concentrations and create parameter estimates for each variable. Results In a bivariate analysis, the use of OCPs at 4 months was associated with increased serum 25(OH)D (p = 0.02). OCPs' use at 7 months was associated with a higher trend in 25(OH)D, but this finding was not statistically significant (p = 0.1). In a multivariate regression model at 4 months, independent positive predictors of 25(OH)D concentrations were the use of OCPs (p = 0.03) and treatment with vitamin D at 6,400 IU/d (p ≤ 0.0001). Negative predictors were Black (p = 0.001) and Hispanic (p = 0.0001) race and ethnicity, and body mass index (BMI) greater than 30 (p = 0.0002). The same pattern occurred at 7 months, with more southern latitude as a positive independent predictor (p = 0.04) of 25(OH)D concentration. Conclusion The use of OCPs was associated with greater 25(OH)D in women who are lactating. Additionally, treatment with vitamin D at 6,400 IU/d and southern latitude was associated with greater 25(OH)D in women who are lactating. Black and Hispanic race and ethnicity, and BMI greater than 30, were independently associated with lower 25(OH)D in women who are lactating. Key Points

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Section: Discussionmentioning

confidence: 99%

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

Huff,

Schulz,

Richardson

et al. 2023

Am J Perinatol

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“…To account for potential drop out 10 participants were recruited per group. Exclusion criteria included any participant that was taking vitamin supplementation, were non-Caucasian, had a skin condition that would prevent them from applying oil to their skin or were taking, had taken a sunny holiday in the last 6-months, planned to take a sunny holiday during the study period, or had been taking in the past 6-months, oestrogen-based contraception 25 . Seventy Caucasian volunteers were recruited from a female university population that included students and academics (latitude 52.58 o N) during the month of March.…”

Section: Methodsmentioning

confidence: 99%

The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial

et al. 2021

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“…Other studies show a correlation between OC use and reduced levels of vitamin B12 and vitamin B6 [ 139 ]. A change in vitamin D levels associated with oral estrogens has also been found [ 140 ]. Thus, some data suggest that dietary management may not be effective in reducing PMS symptoms [ 141 ].…”

Section: Managing Pmsmentioning

confidence: 99%

Relationships between Premenstrual Syndrome (PMS) and Diet Composition, Dietary Patterns and Eating Behaviors

Oboza,

Ogarek,

Wójtowicz

et al. 2024

Nutrients

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Premenstrual Syndrome (PMS) is a disorder between gynecology and psychiatry which includes cognitive, affective, and somatic symptoms from mild to severe. The most severe form of PMS is premenstrual dysphoric disorder (PMDD) and it is considered a form of depressive disorder. An association between diet composition and the occurrence of PMS and its severity have been suggested. As such, this manuscript discusses the relationships between diet composition, dietary patterns and eating behaviors, and PMS. PubMed, Embase, Cochrane, and Web of Science databases were searched for related studies up to 18 January 2024. A text search with the following keywords singly or in combination was conducted: “Premenstrual syndrome”, “Nutrition”, “Diet composition”, “Dietary patterns”, and “Eating behaviors”. Studies published so far showed that low intake of simple carbohydrates, fats, salt, and alcohol, and high of fresh, unprocessed foods rich in B vitamins, vitamin D, zinc, calcium, and omega-3 fatty acids may help prevent the onset of PMS and reduce the severity of its symptoms. However, further studies are needed to formulate definitive recommendations for the use of vitamins, micronutrients and other dietary ingredients supplementation in women with PMS to improve functioning, overall well-being, and physical health. Large, randomized, double-blind clinical trials across diverse populations are necessary to formulate clear recommendations for supplementation in women with PMS.

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The Influence of Hormonal Contraception on Vitamin D Supplementation on Serum 25(OH)D₃ Status in Premenopausal Women: A Prospective Double-Blind Placebo Random Controlled Trial

Cited by 5 publications

References 20 publications

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial

Relationships between Premenstrual Syndrome (PMS) and Diet Composition, Dietary Patterns and Eating Behaviors

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The Influence of Hormonal Contraception on Vitamin D Supplementation on Serum 25(OH)D3 Status in Premenopausal Women: A Prospective Double-Blind Placebo Random Controlled Trial

Cited by 5 publications

References 20 publications

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

Oral Contraceptive Pills Increase Circulating 25-Hydroxy-Vitamin D Concentrations in Women Who Are Lactating

The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial

Relationships between Premenstrual Syndrome (PMS) and Diet Composition, Dietary Patterns and Eating Behaviors

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The Influence of Hormonal Contraception on Vitamin D Supplementation on Serum 25(OH)D₃ Status in Premenopausal Women: A Prospective Double-Blind Placebo Random Controlled Trial