The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation

Tsai, Chun Kuang; Yeh, Chiu Mei; Hong, Ying; Chen, Po Min; Liu, Jin Hwang; Gau, Jyh Pyng; Liu, Chia Jen

doi:10.1038/s41598-021-91135-0

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…A similar experience has been published by Kumar et al, who demonstrated acceptable infection rates and survival in 40 patients who underwent allogeneic HSCT in non-HEPA-filtered rooms without positive pressure 14 . Tsai et al demonstrated that the 100-day mortality in adult patients with multiple myeloma did not differ if the room used was without a HEPA filter 15 .…”

Section: Discussionmentioning

confidence: 99%

Autologous hematopoietic stem cell transplant at a tertiary care centre in India: achieving comparable outcomes with adaptations

2024

BCT

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Autologous stem cell transplantation (ASCT) is the standard treatment for many high-risk solid tumors. Patients undergoing ASCT should be managed in a dedicated hematopoietic stem cell transplantation (HSCT) unit with isolation rooms, high-efficiency particulate air (HEPA) filters, and positive pressure. We report the outcomes of the first 20 pediatric patients who underwent ASCT in isolation rooms with no HEPA filters or positive pressure. Moreover, the isolation rooms were not part of a dedicated HSCT unit. Data from 20 patients were analyzed. All patients included in the study underwent ASCT after harvest and cryopreservation of the hematopoietic stem cells (HSC). Furthermore, all patients also underwent myeloablative conditioning. The most common indications for ASCT included high-risk neuroblastoma (HR-NB) (n=9) and refractory/relapsed Hodgkin's lymphoma (HL) (n=6). The median CD-34 positive HSC administered was 4.5 (0.8-21.9) million per kg. The median time to neutrophil and platelet engraftment was 16.5 (10-35) and 19 (10-87) days, respectively. Additionally, only one transplant-related mortality was observed and the mean time to discharge from the hospital was 27.6+8.3 days. The overall survival for all our patients was 75% at a median follow-up of 33.2 months (15 out of 20 patients survived), and the disease-free survival was 60% (median follow-up, 28.4 months). The overall survival for the patients with HL was 85.7% at a median of 45.3 months and for the HR-NB was 66.7% at a median of 34.9 months. This study provides evidence that ASCT can be safely performed in isolation rooms without HEPA filters and positive pressure if expertise and supportive care are available. In settings with limited resources, such a model could help establish low-cost HSCT units.

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Section: Discussionmentioning

confidence: 99%

Autologous hematopoietic stem cell transplant at a tertiary care centre in India: achieving comparable outcomes with adaptations

2024

BCT

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“…No recommendation can be made for routinely placing a recipient of autologous HSCT or solid organ transplant in a protected environment [ 38 ]. When assessing the effectiveness of the HEPA filtration on reducing treatment-related mortality in multiple myeloma patients receiving autologous stem cell transplantation, Tsai et al found it didn’t affect 100-day mortality [ 64 ].…”

Section: Infection Prevention and Control Measuresmentioning

confidence: 99%

What’s New in Prevention of Invasive Fungal Diseases during Hospital Construction and Renovation Work: An Overview

Mareković

2023

JoF

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The goal of the overview was to give insight into the recent data of invasive fungal diseases (IFDs) associated with construction and renovation in healthcare settings as well as the recent evidence about available prevention and infection control measures. The number of studies describing IFD outbreaks associated with construction or renovation is on the rise again. Applying adequate prevention measures is still a challenge not just for healthcare workers but also for architects and construction workers as well. The role of multidisciplinary teams in the planning and monitoring of prevention measures cannot be overemphasized. Dust control is an inevitable part of every prevention plan. HEPA filters are helpful in the prevention of fungal outbreaks in hematologic patients, but further studies are needed to clarify the extent in which they contribute as specific control measures. The cut-off value for a “threating” level of fungal spore contamination still remains to be defined. The value of antifungal prophylaxis is difficult to assess because other preventive measures are simultaneously applied. Recommendations are still based on few meta-analyses, a large number of descriptive reports, and the opinion of respective authorities. Outbreak reports in the literature are a valuable resource and should be used for education as well as for preparing outbreak investigations.

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Rationally engineered Losmapimod encapsulating polymeric nanoparticles for treatment of human multiple myeloma cells

Hou

et al. 2021

Appl Nanosci

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The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation

Cited by 3 publications

References 42 publications

Autologous hematopoietic stem cell transplant at a tertiary care centre in India: achieving comparable outcomes with adaptations

Autologous hematopoietic stem cell transplant at a tertiary care centre in India: achieving comparable outcomes with adaptations

What’s New in Prevention of Invasive Fungal Diseases during Hospital Construction and Renovation Work: An Overview

Rationally engineered Losmapimod encapsulating polymeric nanoparticles for treatment of human multiple myeloma cells

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