The influence of hepatitis C and iron replacement therapy on plasma pentosidine levels in haemodialysis patients

Nascimento, Marcelo Mazza do; Suliman, Mohamed E.; Bruchfeld, Annette; Hayashi, Shirley Yumi; Manfro, Roberto Ceratti; Qureshi, Abdul Rashid; Pecoits‐Filho, Roberto; Pachaly, Maria Aparecida; Renner, L.; Stenvinkel, Peter; Riella, Miguel C.; Lindholm, Bengt

doi:10.1093/ndt/gfh508

Cited by 20 publications

(17 citation statements)

References 21 publications

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“…although new formulations of iV iron have drastically reduced the risk of immediate adverse effects, a variety of long-term consequences of iV iron have been reported in the literature (15,19). Furthermore, several studies have demonstrated that the administration of iV iron releases free iron, which may react with hydrogen peroxide to produce hydroxyl radical oxidants and may lead to increased oxidative stress that can potentially damage cellular lipids, nucleic acids, proteins and carbohydrates (20,21). iV iron bypasses the physiologic controls of iron absorption and storage, thereby exposing the patient to higher levels of circulating free iron and higher tissue levels of iron.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of oral iron to manage anemia in long-term hemodialysis patients with the use of ultrapure dialysate

Tsuchida¹,

Paudyal²,

Paudyal

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. the aim of this study was to evaluate the effectiveness of oral iron to manage anemia in long-term hemodialysis (hd) patients using ultrapure dialysate. this study was prospectively conducted on 23 patients (11 males and 12 females; median age 60 years, range 35-81) who underwent hd in our hospital from march to September 2007. the patients were randomly assigned to two treatment groups. The first group of 11 patients received ferrous fumarate 305 mg per oral tablet once a day, while the second group of 12 patients received infusions of 50 mg iron in a 0.9% sodium chloride solution. at the end of the 6-month treatment, patients receiving oral iron and intravenous iron had a significant increase in transferrin saturation from baseline (20.1±8.9 to 29.7±7.2; p=0.011 and 17.4±6.1 to 33.7±8.6; p=0.0001, respectively) and ferritin (32.6±15.4 to 115.4±28.2; p=0.0001 and 57.8±26.7 to 183.5±47.5; p=0.0002, respectively). in both groups, hemoglobin, hematocrit and dry weight were increased, but did not reach statistical significance. Moreover, both groups showed a significant reduction in the mean weekly erythropoietin dose from baseline (5,590.9±1,513.6 to 3,727.3±1,618.1; p=0.011 and 6,775.8±2,292.2 to 4,375.0±2,473.7; p=0.027, respectively). Oral iron is indeed as effective as intravenous iron in managing anemia in hd patients using ultrapure dialysate.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of oral iron to manage anemia in long-term hemodialysis patients with the use of ultrapure dialysate

Tsuchida¹,

Paudyal²,

Paudyal

et al. 2010

Experimental and Therapeutic Medicine

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“…5 Several hypotheses have been proposed to explain the pathogenesis including secretion of erythropoietin from regenerating liver cells, 6 induced endogenous thrombopoietin (TPO) secretion, 7 and altered iron metabolism. 8 However, it is not clear whether HBV infection as well as a concurrent HBV and HCV infection is associated with increased red blood cell production.…”

mentioning

confidence: 99%

Chronic Hepatitis C Infection Is Associated with Higher Hemoglobin Levels in Hemodialysis Patients, But Hepatitis B Infection Is Not

Chen¹,

Tseng²,

Huang³

et al. 2008

Dialysis & Transplantation

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BACKGROUNDChronic hepatitis is associated with increased hemoglobin level in patients with end‐stage renal disease. The aim of this study was to define the individual and combined influence of chronic hepatitis B and C infections on red blood cell status.METHODSA total of 524 chronic hemodialysis patients at 5 hemodialysis centers were retrospectively reviewed for the period from March 1 to June 31, 2005. The results of testing using a third‐generation enzyme‐linked immunosorbent assay showed that 345 patients (65.8%) had neither HBV nor HCV (NBC), 55 patients (10.5%) had HBV, 108 (20.6%) had HCV, and 16 (3.1%) had concurrent HBV and HCV infection (BBC). Differences between the 4 groups of patients in the parameters studied were investigated using a multivariate general linear model with the Sidak post hoc test.RESULTSThe hemoglobin and hematocrit of patients with HCV were 10.5 ± 1.6 g/dL and 31.6% ± 4.7%, respectively, which were significantly higher than the 9.9 ± 1.4 g/dL and 29.7% ± 4% of NBC patients (p = 0.002 and p = 0.001). The erythropoietin (EPO) dose given to patients with HCV was 39.3 ± 40.3 IU/kg/week, significantly lower than the 58.1 ± 40.6 IU/kg/week for those with NBC. The results of the multivariate linear regression analysis suggested that erythropoietin dose, elevated liver functional test results, and HCV infection were major factors affecting red cell production (p < 0.001, p < 0.02, and p < 0.05, respectively).CONCLUSIONHepatitis C virus infection was associated with an increased number of red blood cells, which led to a lowering of the necessary EPO dose, whereas hepatitis B virus infection was not.

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“…Some authors, such as Nascimento et al, reported increased OS in infected patients, whereas others reported decreased OS [10,11]. Based on these results, the present study investigated a possible relationship of OS in patients of HD units and with HCV infection.…”

Section: Introductionmentioning

confidence: 81%

Oxidative stress: A comparison of different groups of patients with Hepatitis-C in hemodialysis units

Nmo¹,

Ac²,

Bm³

et al. 2015

clinical-practice

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The influence of hepatitis C and iron replacement therapy on plasma pentosidine levels in haemodialysis patients

Abstract: HCV in HD patients is associated with increased pentosidine levels, possibly reflecting increased oxidative stress. The association between pentosidine and ferritin levels may suggest an impact of i.v. iron therapy.

Cited by 20 publications

References 21 publications

Effectiveness of oral iron to manage anemia in long-term hemodialysis patients with the use of ultrapure dialysate

Effectiveness of oral iron to manage anemia in long-term hemodialysis patients with the use of ultrapure dialysate

Chronic Hepatitis C Infection Is Associated with Higher Hemoglobin Levels in Hemodialysis Patients, But Hepatitis B Infection Is Not

Oxidative stress: A comparison of different groups of patients with Hepatitis-C in hemodialysis units

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