The influence of heparin on the blood eosinophil

Bone Marrow Morphology in Patients on Regular Haemodialysis Treatment

“…It is known that eosi nophilia may be the result of a reaction of antigen and antibody of IgE class fixed to the surface of mast cells [5]. There are also observations that certain patients on heparin therapy appeared to exhibit an eosinophilia [1,12], A third explanation may be the finding of high frequencies of eosinophils adhered to the dialyser membranes thus stressing the bone marrow to produce more eosinophils [13].…”

The effect of cationic charge on release of eosinophil mediators

“…44,45 Our study proposes an important role for a cationic environment in eosinophil mediator release. Although the association of eosinophils and extracellular cationic charge was suggested almost 4 decades ago, 46,47 this is the first study to determine the important nature of eosinophil-cationic charge interactions at a functional level. Our data suggest that eosinophil cationic products might induce a positive feedback loop to activate eosinophils further by increasing cell-surface receptor polarization to a target.…”

Eosinophilia in Uremia

“…It thus appears that full blown peripheral eosinophilia does not set in abruptly on initiation of dialysis, but rather progresses gradually in a subgroup of the dialysis population. This would suggest that the re sponsible factor does not consist of exposure to foreign sensitizing material such as heparin [4] or the dialyzing membrane [2], Preferably, the hypothesis of a nondialyzable 'uremic toxin' as the causative agent would be more plausible. Since marrow [1] and peripheral [2] eosino philia have been similarly observed in other dialysis popu lations.…”