The Influence of Graphene Content on the Antibacterial Properties of Polycaprolactone

Abstract

This work contains an analysis of the impact of modifying a bioresorbable polymer—polycaprolactone (PCL)—with various additives on its antibacterial properties. To this end, samples of PCL filament containing various content levels of graphene (GNP), 0.5%, 5%, 10%, were obtained using injection molding. Polymer samples without additives were used for comparison. The next step was to assess the antimicrobial impact of the preparations under study against the following microorganisms: Staphylococcus aureus ATCC 25293, Escherichia coli ATCC 25922, Candida albicans ATCC 10231. Effective bactericidal activity of PCL with small amount of GNP, especially against C. albicans and S. aureus was confirmed. A decrease in this property or even multiplication of microorganisms was observed in direct proportion to the graphene content in the samples.

Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

“…However the profound antibacterial activity of FCZ‐ZnO‐HAp‐PCL nanocomposite may be due to presence of PCL and HAp NPs. PCL shows activity against microbes likes E. coli when it is modified with other metals or metal oxides and hydroxyapatite exhibited exhibit profound antibacterial properties against both Gram‐positive and Gram‐negative bacteria [39,40] …”

“…PCL shows activity against microbes likes E. coli when it is modified with other metals or metal oxides and hydroxyapatite exhibited exhibit profound antibacterial properties against both Grampositive and Gram-negative bacteria. [39,40] The antifungal activity analysis of ZnO, HAp, and the FCZ-ZnO-HAp-PCL composite against Candida albicans and Aspergillus niger at varying concentrations of 10 μg mL À 1 , 30 μg mL À 1 , 100 μg mL À 1 by the well diffusion method is shown in Table 2. The results showed that FCZ-ZnO-HAp-PCL nanocomposite was more effective in inhibiting exercise than ZnO and HAp nanoparticles.…”

Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit Candida albicans and Candida auris Adhesion and Biofilm Formation?

“…Among several polymers, polycaprolactone (PCL) is a promising biomaterial for bone regeneration in the medical field due to its numerous properties. In particular, PCL is a highly biocompatible and bioresorbable polymer that, upon its implantation, is not necessary to remove at the end of its function [ 4 , 5 ]. PCL is also a suitable biomaterial for producing three-dimensional (3D) constructs, called scaffolds, which are an advanced therapeutic solution for cavity-filling in bone disease or for the healing of fractured bone [ 6 , 7 , 8 ].…”

3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

“…Recently, we were successful in developing pure PCL filament sticks using injection molding and successfully used them for FDM [ 28 ]. As a further improvement, we produced composite filaments made of a PCL matrix with 0.5, 5, 10 percentages of graphene as a filler [ 29 , 30 ]. We have already proved that the addition of small amounts of graphene, bioglass or zinc-doped bioglass significantly enhance PCL antibacterial efficacy [ 31 ] and that the presence of Zn 2+ ions in the electrospun polycaprolactone membranes influence the osteogenic differentiation of cells [ 32 ].…”