The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo

Jansson, Björn; Hägerström, Helene; Fransén, Nelly; Edsman, Katarina; Björk, Erik

doi:10.1016/j.ejpb.2004.10.001

Cited by 63 publications

(27 citation statements)

References 32 publications

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“…The production yields of microspheres of various batches were calculated using the weight of finally dried microspheres with respect to the initial total quantity of the drug and polymer used. Percent production yields were calculated as per the formula mentioned below, and reported in Table 2 [7].…”

Section: Morphological Examinationmentioning

confidence: 99%

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Shah¹,

Sharma²,

Vijay³

et al. 2010

Int j Drug delivery

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The aim of the present study was to prepare gellan gum microspheres of Sildenafil citrate, for intranasal delivery to avoid the first pass metabolism. The microspheres were prepared using spray drying method. The microspheres were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, in-vitro mucoadhesion, ex-vivo mucoadhesion, thermal analysis, XRD study and invitro drug release. Treatment of in-vitro data to different kinetic equations indicated diffusion controlled drug delivery from gellan gum microspheres. The results of DSC and XRD studies revealed the molecular amorphous dispersion of Sildenafil citrate into the gellan gum microspheres. Microspheres so prepared were discrete, bulky, free flowing and showed an average encapsulation efficiency ranging from 95-98%. The formulation exhibited a good mucoadhesive strength which was determined in in vitro conditions through falling film technique and was compared with ex vivo studies. The microspheres so prepared also exhibited a good swelling index which confirmed the strong mucoadhesive property of the formulation.

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Section: Morphological Examinationmentioning

confidence: 99%

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Shah¹,

Sharma²,

Vijay³

et al. 2010

Int j Drug delivery

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show abstract

“…Liquid nasal sprays are useful dosage forms for local and systemic delivery, but often suffer 20 from poor retention, dripping out of the nose or down the back of the throat, which leads to 21 reduced bioavailability (Jansson et al, 2005). Many ways have been introduced to address this 22 problem; one such way is by formulating nasal sprays that contain polymers which are formulations to predict the stress required to initiate flow.…”

mentioning

confidence: 99%

Development of mucoadhesive sprayable gellan gum fluid gels

Mahdi

Conway

Smith

2015

International Journal of Pharmaceutics

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“…Anyhow, some significant results obtained in the last decade will be reported here. In order to demonstrate that high molecular weight substances are capable of crossing the nasal mucosa, gellan gel formation upon contact with the nasal mucosa was investigated for an evaluation of the increased and prolonged uptake of 3000 Da fluorescein dextran in comparison with a mannitol solution [52]. Using different concentrations of gellan, Cao et al [12] prepared an ion-activated in situ gel system loaded with scopolamine HBr, and the antimotion sickness efficacy was investigated in rats and compared with subcutaneous and oral administrations of the same drug.…”

Section: Nasal Deliverymentioning

confidence: 99%