The Influence of Food, Posture, and Other Factors on the Alveolar Carbon Dioxide Tension in Man

Higgins, Harold L.

doi:10.1152/ajplegacy.1914.34.1.114

Cited by 40 publications

(12 citation statements)

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“…A smaller, but qualitatively similar respiratory compensation, has also been observed in cats (Ou and Tenney, 1974) and humans (e.g. Higgins, 1914;Erdt, 1915;Van Slyke et al, 1917 .…”

Section: Effects Of Digestion On Arterial Acid-base Parameters Andsupporting

confidence: 54%

“…Thus, the increased PaCO∑ during digestion is not caused by inefficient ventilatory response to elevated metabolism, or a more relaxed state during the postprandial period (Higgins, 1914). Instead, our data strongly suggest that the ventilatory compensation of the alkaline tide represents a regulated response that serves to maintain pHa and not PaCO∑.…”

Section: Effects Of Inhibiting Gastric Acid Secretion On Arterialmentioning

confidence: 62%

“…The postprandial period is characterised, therefore, by a metabolic alkalosis that is almost fully compensated by an increased PCO∑ that appears to be caused by hypoventilation, as ventilation does not increase proportionally to CO2 production (Glass et al, 1979;Wang et al, 2001). Smaller but qualitatively similar respiratory compensations have also been observed in mammals (Higgins, 1914;Erdt, 1915;Van Slyke et al, 1917;Ou and Tenney, 1974).…”

mentioning

confidence: 91%

“…As an alternative, it has been suggested that increased PaCO∑ during digestion in humans is caused by the induction of a more relaxed state with low responsiveness to ventilatory stimuli (e.g. Higgins, 1914), as has been observed during sleep.…”

mentioning

confidence: 99%

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Ventilatory compensation of the alkaline tide during digestion in the snakeBoa constrictor

Andrade

Toledo

Abe

et al. 2004

Journal of Experimental Biology

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SUMMARYThe increased metabolic rate during digestion is associated with changes in arterial acid–base parameters that are caused by gastric acid secretion(the `alkaline tide'). Net transfer of HCl to the stomach lumen causes an increase in plasma HCO3– levels, but arterial pH does not change because of a ventilatory compensation that counters the metabolic alkalosis. It seems, therefore, that ventilation is controlled to preserve pH and not PCO2 during the postprandial period. To investigate this possibility, we determined arterial acid–base parameters and the metabolic response to digestion in the snake Boa constrictor, where gastric acid secretion was inhibited pharmacologically by oral administration of omeprazole.The increase in oxygen consumption of omeprazole-treated snakes after ingestion of 30% of their own body mass was quantitatively similar to the response in untreated snakes, although the peak of the metabolic response occurred later (36 h versus 24 h). Untreated control animals exhibited a large increase in arterial plasma HCO3– concentration of approximately 12 mmol l–1, but arterial pH only increased by 0.12 pH units because of a simultaneous increase in arterial PCO2 by about 10 mmHg. Omeprazole virtually abolished the changes in arterial pH and plasma HCO3– concentration during digestion and there was no increase in arterial PCO2. The increased arterial PCO2 during digestion is not caused, therefore, by the increased metabolism during digestion or a lower ventilatory responsiveness to ventilatory stimuli during a presumably relaxed state in digestion. Furthermore, the constant arterial PCO2, in the absence of an alkaline tide, of omeprazole-treated snakes strongly suggests that pH rather than PCO2 normally affects chemoreceptor activity and ventilatory drive.

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“…A smaller, but qualitatively similar respiratory compensation, has also been observed in cats (Ou and Tenney, 1974) and humans (e.g. Higgins, 1914;Erdt, 1915;Van Slyke et al, 1917 .…”

Section: Effects Of Digestion On Arterial Acid-base Parameters Andsupporting

confidence: 54%

Section: Effects Of Inhibiting Gastric Acid Secretion On Arterialmentioning

confidence: 62%

mentioning

confidence: 91%

mentioning

confidence: 99%

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Ventilatory compensation of the alkaline tide during digestion in the snakeBoa constrictor

Andrade

Toledo

Abe

et al. 2004

Journal of Experimental Biology

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show abstract

“…Such variations are to be expected. The work of Higgins (29) and later of Dodds (30) on alveolar air values, during the course of the day, and that of Cullen and Earle (31) more recently, on the arterial pH. and CO2 tensions, show that considerable variations take place, and it is reasonable to suppose similar changes in mixed venous levels.…”

Section: Results (A) Oxygenated Mixed Venous Blood Tensionsmentioning

confidence: 86%