The influence of field size, treatment modality, commissure involvement and histology in the treatment of early vocal cord cancer with irradiation

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

“…Anterior commissure involvement has often been regarded as an indication for surgery rather than radiotherapy, because of allegedly poor results of the latter [2,26,35]. However, our experience showed no significant difference in local control related to AC involvementthose without AC involvement showing a local control of 94% and those with involvement 89%.…”

Impact of Anterior Commissure Involvement on Local Control of Early Glottic Carcinoma Treated by Laser Microresection

“…Thus, primary radiotherapy seems to be an effective and voice‐preserving treatment modality for glottic tumors involving the anterior commissure 21 . In contrast, other investigators 4,22–27 regarded anterior commissure involvement to be associated with a decrease in local control rate with the use of primary radiotherapy in early glottic cancer. Marshak et al 28 observed a decrease in the 5‐year local control rate, with anterior commissure involvement from 89% to 74%.…”

Significance of pretreatment hemoglobin level in patients with T1 glottic cancer

“…[5,6] Many reports have evaluated potential host, tumor, and treatment factors for their effect on local control in early glottic carcinomas. Factors associated with adverse prognosis include male gender [7], higher histologic grade [8], anterior commissure involvement [9], smaller dose per fraction [4], prolonged overall treatment time [10], and higher beam energy [11]. In addition, a recent study reported that pretreatment hemoglobin levels ഛ 13 gm/dl were associated with a significant decrease in local control and overall survival in patients with T1 and T2 glottic carcinomas treated with primary radiation therapy [12].…”