The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study

Obesity and reproduction: a committee opinion

“…More specifically, of 12,566 Danish couples undergoing assisted reproduction, overweight and obese ovulatory women had 12% (95% CI, 0.79-0.99) and 25% (95% CI, 0.63-0.90) reductions in IVF-related live-birth rate, respectively (referent BMI, 18.5-24.9 kg/m 2 ) (54). In this cohort there was a 2% (95% CI, 0.97-0.99) decrease in livebirth rate for every one-unit increase in BMI (54). In another retrospective analysis of 487 couples undergoing assisted reproduction, obesity had the greatest negative impact on pregnancy outcome in young women (<25 years [OR 0.93; 95% CI, 0.87-0.98]; referent BMI, 18.5-24.9 kg/m 2 ) (45).…”

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

“…Overweight or obese women have reduced pregnancy and live-birth rates (188)(189)(190)(191), which can be overcome by using donor oocytes (192), which implicates oocyte quality as the primary factor impairing IVF outcomes in these women (193). Obesity alters oocyte morphology (194); reduces oocyte fertilization in some (195,196), but not all (194,197,198), studies; and impairs embryo quality and the IVFrelated live-birth rate, particularly in women less than 35 years of age (189,197).…”

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

“…Women who are overweight are less likely to ovulate (240) and spontaneously conceive (256), and upon conception, they have an increased risk of miscarriage and are predisposed to an adverse pregnancy outcome (15). Obesity appears to alter the follicular fluid environment (282), the ooplasm of the oocyte, and leads to a reduction in fertilization and impairs embryonic development (92).…”