The influence of fatigue on health-related quality of life in patients with Parkinson's disease

Abstract

PD has a substantial negative impact on HRQL. We found a strong correlation between fatigue and high distress scores on HRQL scales in a population of patients with PD who were not depressed or demented. The diversity of symptoms and high prevalence of non-motor features, including fatigue, is important to take into account in our efforts to optimize treatment and care for this patient group.

Perceptions of effort during handgrip and tongue elevation in Parkinson's disease

“…In the task involving self-ratings of effort using a DME paradigm, subjects with PD provided significantly higher ratings of effort for general daily activities and for speech. This result is consistent with a growing body of literature indicating that increased levels of effort and fatigue are prevalent in PD and that persons with the disease report that fatigue affects specific activities of daily living [1][2][3][4].…”

“…Most patients with PD include fatigue as one of their three most prominent symptoms, and claim that it substantially impacts quality of life [1][2][3][4], yet neurologists tend to underdiagnose fatigue as a presenting symptom of PD [5]. Clinically, fatigue can be described as an "overwhelming sense of tiredness, lack of energy, or feeling of exhaustion" [6].…”

Fatigue level in spinal cord injury AIS D community ambulatory subjects

“…[3][4][5][6] However, there are few studies about fatigue in the SCI population. 1,[7][8][9][10] Furthermore, fatigue in SCI has been correlated with other clinical symptoms such as pain, depression 1,2,[8][9][10] and the effect of medication.…”

“…10 Pain is one of the most frequent factors related to fatigue in literature. 2,6,8,9 Depression is a very common symptom that also contributes to higher levels of perceived fatigue. 9,11 A relationship was described among SCI wheelchair users and fatigue, describing that the higher the physical activity, the lower the fatigue severity scale (FSS) scale.…”

Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

“…Fatigue is multifactorial and has been set as a general sense of tiredness or difficulties in starting an activity on the physical or mental sector experienced by an individual during many days or weeks [5]. Nearly 58% of patients with PD present fatigue [2] [6], with higher incidence in advanced stages of PD [7]. Fatigue is linked with serotonergic dysfunction in basal ganglia and limbic circuits [8] [9], and in thalamus, additional cortical and striatal regions [10].…”