The influence of extra-oral time upon healing after tooth replantation A histological study in rat incisors.

Leite, Mateus Carvalho; Okamoto, Tetuo

doi:10.2334/josnusd1959.26.316

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…In such situation, periodontal ligament cells had already degenerated and the root of the replanted tooth becomes susceptible to both resorption and ankylosis processes 12 . Such results have been demonstrated in human 3 , monkey 1 , dog 20 and rat models 17 .…”

Section: Discussionmentioning

confidence: 54%

“…According to them, some procedures have been advised to be performed before replantation in an attempt to slow down the beginning of root resorption and enhance the longevity of the replanted tooth, such as immersion of the avulsed tooth in a fluoride solution to increase its resistance to resorption 2 , 10 , 28 . In addition, considering that the necrotic periodontal ligament stimulates root resorption 17 , 19 , 30 , removal of PDL remnants has also been pointed out as an advisable approach 10 , 19 , 30 . Although both mechanical 2 , 16 and chemical 9 , 15 , 19 , 23 , 26 , 27 procedures have been employed for such purpose, it has been advocated that chemical procedures aid the preservation of the cementum layer, which is more resistant to resorption and should therefore be maintained 19 .…”

Section: Introductionmentioning

confidence: 99%

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Delayed tooth replantation after root surface treatment with sodium hypochlorite and sodium fluoride: histomorphometric analysis in rats

et al. 2006

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In cases of delayed tooth replantation, non-vital periodontal ligament remnants have been removed with sodium hypochlorite in an attempt to control root resorption. Nevertheless, reports of its irritating potential in contact with the alveolar connective tissue have been described. Therefore, this study evaluated the healing process on delayed replantation of rat teeth, after periodontal ligament removal by different treatment modalities. Twenty-four rats, assigned to 3 groups (n=8), had their upper right incisor extracted and left on the workbench for desiccation during 60 min. Afterwards, the teeth in group I were immersed in saline for 2 min. In group II, root surfaces were scrubbed with gauze soaked in saline for 2 min; and in group III, scrubbing was done with gauze soaked in 1% sodium hypochlorite solution. Thereafter, root surfaces were etched with 37% phosphoric acid and immersed in 2% acidulate-phosphate sodium fluoride solution, at pH 5.5. Root canals were filled with a calcium hydroxide-based paste and the teeth were replanted. The animals were sacrificed 60 days postoperatively and the pieces containing the replanted teeth were processed and paraffin-embedded. Semi-serial transversally sections were obtained from the middle third of the root and stained with hematoxylin and eosin for histomorphometric analysis. Data were analyzed statistically using Kruskal-Wallis and Dunn's tests. The results showed that root structure and cementum extension were more affected by resorption in group III (p<0.05). All groups were affected by root resorption but the treatment performed in group III was the least effective for its control. The treatment accomplished in groups I and II yielded similar results to each other.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Delayed tooth replantation after root surface treatment with sodium hypochlorite and sodium fluoride: histomorphometric analysis in rats

et al. 2006

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“…This animal model was complemented by cell culture to address whether the addition of RANKL and NAC to RAW264.7 cells affected osteoclast differentiation. Luxated teeth have a favorable prognosis after replantation if drying time is kept short and/or they are kept in an appropriate storage solution [14,15]. However, with prolonged drying time and delayed replantation, the periodontal membrane and dental pulp tissues undergo necrosis, and root resorption frequently occurs in cases with particularly poor prognoses.…”

Section: Discussionmentioning

confidence: 99%

Effects of N-acetylcysteine on root resorption after tooth replantation

Nishimi

Nakamura

Hisada

et al. 2020

Pediatric Dental Journal

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In the case of complete luxation with dental trauma, delayed replantation leads to a higher probability of root resorption. We evaluated the efficacy of N-acetylcysteine (NAC) as a root canal medication for trauma-associated root resorption. A rat dental trauma model was used. In the test group, mesial root pulpectomy was carried out after tooth extraction. NAC was applied as a root canal medication followed by replantation. We euthanized the rats after two weeks, excised the maxilla, and prepared thin sections, followed by H-E and TRAP staining. Furthermore, RAW264.7 cells were treated with RANKL and NAC. The effects of NAC on osteoclast differentiation were investigated by determining the numbers of osteoclasts and nuclei and quantifying osteoclast-related mRNA expression levels by real-time PCR. The level of root resorption and number of odontoclasts tended to be lower in the NAC groups than in the control group. In terms of osteoclast differentiation, the total number of osteoclasts was lower in both the 5 and 10 mmol/L NAC groups than in the control group. Real-time PCR revealed that the expression levels of RANK , NFATc1 , DC-STAMP , CD47 , and cathepsin K were lower in the 10 mmol/L NAC group. NAC tended to inhibit root resorption and reduce the number of odontoclasts. NAC also inhibited the expression of osteoclast-related genes. Overall, NAC reduced the number of odontoclasts, inhibited bone resorption, and influenced the inhibition of osteoclast differentiation, fusion, and functions. Therefore, we suggest that NAC may be beneficial in the treatment of root resorption.

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“…1,2 For most authors, the success of tooth replantation depends on maintaining the vitality of the periodontal ligament. [3][4][5][6][7][8][9][10][11][12][13] Without the biological protection of the periodontal ligament, cementum becomes replaced by bone tissue, and the root can be replaced completely by this tissue. 13,14 On the other hand, remaining necrotic periodontal ligament can be replaced by bone or initiate a process of resorption.…”

Section: Introductionmentioning

confidence: 99%

Histometric Study of Resorption on Replanted Teeth with Enamel Matrix-derived Protein

Oliveira¹,

Bentregani²,

Pasternak³

et al. 2013

The Journal of Contemporary Dental Practice

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The influence of extra-oral time upon healing after tooth replantation A histological study in rat incisors.

Abstract: The authors studied, through replantation of rat incisors, the effect of extraalveolar time upon postoperative events. Root resorption and ankylosis seemed to be particularly affected by this factor.

Cited by 8 publications

References 17 publications

Delayed tooth replantation after root surface treatment with sodium hypochlorite and sodium fluoride: histomorphometric analysis in rats

Delayed tooth replantation after root surface treatment with sodium hypochlorite and sodium fluoride: histomorphometric analysis in rats

Effects of N-acetylcysteine on root resorption after tooth replantation

Histometric Study of Resorption on Replanted Teeth with Enamel Matrix-derived Protein

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