The influence of experimental conditions on the efficiency of labeling of bleomycin with 99Tcm, using Sn(II) as the reductant

Bartels, P.J.; Dekker, B.G.; Ligny, C.L. De; Oldenburg, S.J.

doi:10.1016/0020-708x(78)90152-7

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…BLM is produced by a strain of Streptomyces verticillus as mixture of about 19 sulfur containing glycopeptides, which only differ in the terminal amine moiety (molecular weight about 1500). [1][2][3][4][5] Certain enzymes in tissues and body fluids may play a role through the detoxification process and may influence the composition and availability of steroid hormones, toxins, or carcinogens. 6 One of the most important detoxification processes occurs through glucuronidation conjugation.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Koçan

Avcıbaşı²,

Ünak³

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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The metabolic comparison of bleomycin (BLM) and bleomycin-glucuronide (BLMG) radiolabeled with (99m)Tc ((99m)Tc-BLM and (99m)Tc-BLMG, respectively) has been investigated in this study. Quality control procedures were carried out using thin-layer radiochromatography and high-performance liquid chromatography. To compare the metabolic behavior of BLM and its glucuronide conjugate radiolabeled with (99m)Tc, scintigraphic, and biodistributional techniques were applied using male New Zealand rabbits and Albino Wistar rats. The results obtained have shown that these compounds were successfully radiolabeled with a labeling yield of about 100%. Maximum uptakes of (99m)Tc-BLM and (99m)Tc-BLMG metabolized as N-glucuronide were observed within 2 hours in the liver, the bladder, and the spinal cord for (99m)Tc-BLM and the lung, the liver, the kidney, the large intestine, and the spinal cord for (99m)Tc-BLMG, respectively. Scintigraphy and biodistributional studies performed on the experimental animals have shown that radiopharmaceutical potentials of these compounds are completely different. At the same time, uptake of the (99m)Tc-BLMG was found to be better than that of (99m)Tc-BLM.

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Section: Introductionmentioning

confidence: 99%

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Koçan

Avcıbaşı²,

Ünak³

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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Assessment of ^99mTc‐labelled gentamicin in renal functional imaging

Ozker

Urgancioglu

1985

Labelled Comp Radiopharmac

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Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine

Meares¹,

Remier²,

Goodwin³

1979

Bleomycin: Chemical, Biochemical, and Biological Aspects

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The influence of experimental conditions on the efficiency of labeling of bleomycin with 99Tcm, using Sn(II) as the reductant

Cited by 6 publications

References 5 publications

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Assessment of ^99mTc‐labelled gentamicin in renal functional imaging

Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine

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The influence of experimental conditions on the efficiency of labeling of bleomycin with 99Tcm, using Sn(II) as the reductant

Cited by 6 publications

References 5 publications

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc

Assessment of 99mTc‐labelled gentamicin in renal functional imaging

Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine

Contact Info

Product

Resources

About

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Assessment of ^99mTc‐labelled gentamicin in renal functional imaging