The influence of exercise on the inorganic phosphates of the blood and urine

Havard, R. E.; Reay, G. A.

doi:10.1113/jphysiol.1926.sp002272

Cited by 46 publications

(7 citation statements)

References 8 publications

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“…-An increase in the concentration of inorganic phosphorus in the blood during exercise has been described by Havard and Reay [1926], Dill, Talbott and Edwards [1930], and Gemmill and Ribiero [1933]. In the studies of Harvard and Reay [1926] and Gemmill and Ribiero [1933] strenuous exercise was followed by a gradual decrease in the concentration of inorganic phosphorus, but this was not observed following the light exercise of the present studies.…”

Section: Discussionsupporting

confidence: 61%

Observations on the Course of the Metabolic Events Accompanying Mild Exercise

et al. 1968

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The ventilation and the oxygen uptake rise during the first 5 min. of mild exercise, remain at a new high level until the end of exercise, and then fall again during the succeeding 5 min. The response of the ventilation and the oxygen uptake are, therefore, similar to the output of a simple damped system in the presence of a square-waved input.The metabolic response is considerably more complex than the respiratory. This is not only because of the divergent changes of many different substances, but also because these changes arise at specifically different times during the course of events.There appear to be three major groups of disturbances of the composition of the blood accompanying exercise -one group associated with beginning of exercise, one group which is maintained throughout exercise, and one group which is specifically associated with the period of recovery.During the first 5-15 min. after the beginning of exercise there is an increase in the concentration of lactate and pyruvate, the latter reaching its maximum about 5 min. after the former. The increased concentration of lactate is associated with a fall in pH and standard bicarbonate. At the same time there is a transient fall in the free fatty acids in the plasma. All these phenomena also accompany exercise of shorter duration, in which case they continue to evolve after exercise has stopped and the concentration of lactate remains high long after the oxygen uptake has returned to its initial resting level.More prolonged exercise reveals a number of disturbances which would seem to continue indefinitely during the period of exertion. These consist of a certain degree of elevation of the concentration of lactate and pyruvate, and of the serum potassium, sodium and inorganic phosphorus. The concentration of free fatty acids is maintained at a level at or a little above that which existed before exercise. The concentration of glucose is not greatly affected.Immediately after the end of prolonged exercise, the concentration of lactate declines, although, in mild exercise, this usually appears to be a continuation of a process which had already started during exercise. By contrast, during the first few minutes of recovery, the concentration of pyruvate usually shows a transient increase which is followed by a more sustained fall. The concentrations of potassium, sodium and phosphorus fall again at this time, and there is evidence from the literature that a sustained and substantial fall in phosphorus may occur. Immediately after the end of excercise, there is an increase in the concentration of glucose and free fatty acids which may be of considerable magnitude and duration.THE influence of exercise on the concentration of lactic acid in the blood has been studied for more than half a century. Nevertheless, as has been pointed out by , the interpretation of much of the published observations is obscured by the omission of one or other of the factors which are known now to be important in such studies.

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Section: Discussionsupporting

confidence: 61%

Observations on the Course of the Metabolic Events Accompanying Mild Exercise

et al. 1968

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“…: the difference could only be explained by supposing that the muscle fibres were impermeable to inorganic phosphate. Such an impermeability, however, was not in keeping with the fact established by Havard and Reay (7) that the concentration of phosphate in blood might change as the result of muscular exercise, and with the increased excretion of phosphorus in urine found by Embden and Grafe (8) under like conditions. Havard and Reay pointed out that the small rise in the phosphorus concentration of blood which took place during and immediately after exercise was followed by a rapid fall well below normal: they interpreted this fall as due to the Rockefeller Foundation Fellow.…”

mentioning

confidence: 76%

The concentration and diffusion of inorganic phosphate in living muscle

Stella¹

1928

The Journal of Physiology

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“…Forty-five years ago Havard & Reay (1926) found an increase of 10% in plasma P in finger blood taken 1-4 min after 4-5 min vigorous stair climbing, and of 25 % after 10-15 min of running. They thought that this was due to the release of phosphate from the muscles.…”

Section: Discussionmentioning

confidence: 99%