The influence of excipients on dissolution of caffeine from granules

Szumiło, Michał; Zimmer, Łukasz; Świąder, Katarzyna; Belniak, Piotr; Dwornicka, Dorota; Paź, Celina; Poleszak, Ewa

doi:10.12923/j.2084-980x/25.2/a.19

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lowest moisture content had granules III – 0.58%. These observations are consistent with the results of the study by Szumilo et al (2012), which found that the addition of starch increases the moisture content of the preparation as well. The presence of mannitol and calcium hydrophosphate contributes in reduction of the moisture level in the granules.…”

Section: Discussionsupporting

confidence: 93%

Assessment of physical properties of granules with paracetamol and caffeine

Szumiło

Belniak

Świąder

et al. 2017

Saudi Pharmaceutical Journal

Self Cite

View full text Add to dashboard Cite

Caffeine increases the analgesic properties of acetaminophen and therefore it is reasonable to use both substances together in one drug form in stronger pain. Currently, there are no commercially available pharmaceutical combination products containing acetaminophen and caffeine, which is present as granules. The aim of the study was to obtain twelve different granules with these therapeutic substances and determine the effect of various excipients on the quality of the drug form. All the granules were made by wet granulation. Two types of binders were used: polyethylene glycol 6000 (PEG) and polyvinylpyrrolidone K30 (PVP) as well as different types of fillers. The physical properties of granules were assessed in accordance to the requirements of the European Pharmacopoeia 8th ed. The highest apparent density was found in preparations containing calcium hydrophosphate (0.609 g/mL) and the lowest - containing mannitol (0.353 g/mL) as a filler. The Hausner ratio of most prepared granules ranged from 1.05 to 1.11, while the compressibility index ranged from 4.59 to 10.48%. The evaluation of properties of individual granules helped to indicate formulation with good features, which perhaps will be a good alternative to currently available painkillers with caffeine and acetaminophen.

show abstract

Section: Discussionsupporting

confidence: 93%

Assessment of physical properties of granules with paracetamol and caffeine

Szumiło

Belniak

Świąder

et al. 2017

Saudi Pharmaceutical Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, the caffeine tablets obtained using a wet granulation method and with PVP contents of 1, 2.5, 5 and 10% showed that the dissolution rate of the drug decreased with the increase in the proportion of the binder (PVP). The fastest dissolution of the active substance took place with the lowest amount of PVP (1% w/w) in the tablet [20].…”

Section: Effect Of the Excipients On The Release Profile Of Ibuprofen...mentioning

confidence: 99%

Effect of Components and Deposition on Technological Performance of Ibuprofen Tablets

Velasco¹,

Robles²

2018

Int J App Pharm

View full text Add to dashboard Cite

Objective: This work evaluated the influence of the technological properties of polyvinylpyrrolidone (PVP), calcium phosphate (CP) and cross-linked sodium carboxymethylcellulose (CC) as well as the deposition of a solid dispersion, through the solvent evaporation method, on the technological parameters that define the properties of ibuprofen tablets. Methods: The powder flow rate through an orifice, bulk volume and tapped volume of powders, tablet hardness, disintegration time and dissolution profile of the tablets were determined on individual components, their physical mixtures, granules obtained by deposition and solvent evaporation, and tablets obtained at different compaction pressures. Results: The very poor flowability of CP and the high compactibility of PVP were transferred to the powder mixtures, which showed poor flowability, and ibuprofen tablets with twice the compactibility. The tablets disintegration was high with a low proportion of CC (0.5%), but decreased linearly by increasing the proportion of the disintegrant up to 10%. At the same time, the dissolution of the drug after 30 min increased from 3% to 80%. The agglomeration of CP through the deposition of an alcoholic solution of the drug and PVP improved the flow properties and tripled the hardness of the tablets. However, the dissolution after 30 min decreased from 80% to 18%. Conclusion: The physical mixture was the best option to improve the dissolution, while the deposition on an adsorbent, of a solid dispersion of drug-PVP, was the best option to improve the compactibility and flow properties.

show abstract

The influence of excipients on dissolution of caffeine from granules

Cited by 2 publications

References 0 publications

Assessment of physical properties of granules with paracetamol and caffeine

Assessment of physical properties of granules with paracetamol and caffeine

Effect of Components and Deposition on Technological Performance of Ibuprofen Tablets

Contact Info

Product

Resources

About