The influence of estrous cycle and intrastriatal estradiol on sensorimotor performance in the female rat

Becker, Jill B.; Snyder, Peter J.; Miller, Melissa M.; Westgate, S. A.; Jenuwine, Michael J.

doi:10.1016/0091-3057(87)90476-x

Cited by 161 publications

(62 citation statements)

References 39 publications

(45 reference statements)

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“…Thus far, it has been determined that caveolin proteins functionally link estrogen receptors with mGluRs in striatal neurons [92]; other regions await verification. Through influencing these additional regions, rapid estrogen receptor signaling has been suggested to modulate multiple cellular processes, such as motor control and drug addiction [12,[95][96][97], sexual receptivity [91], the control of the estrous cycle [98], and nociception [14,99]. Furthermore, while we and others hypothesize GPCRs to act as intermediaries between estrogen receptors and G proteins, others have postulated that estrogen receptors directly activate the G proteins [100].…”

Section: Caveolin Proteins and Estrogen Receptorsmentioning

confidence: 84%

Caveolin proteins and estrogen signaling in the brain

Luoma

Boulware

Mermelstein

2008

Molecular and Cellular Endocrinology

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Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin associated proteins include G protein coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinases, ion channels and various other signaling enzymes. Not surprisingly, a wide array of biological disorders are thought to be rooted in caveolin dysfunction. In addition, caveolins also traffic and cluster estrogen receptors to caveolae. Interactions between the estrogen receptors ERα and ERβ with caveolins appear critical in many non-neuronal cell types, e.g. disruption of normal function may underlie many forms of breast cancer. Recent findings suggest caveolins may also play an essential role in membrane estrogen receptor function in the nervous system. Not only are they expressed in neurons and glia, but different caveolin isoforms also appear necessary to generate distinct functional signaling complexes. With membrane estrogen receptors responsible for the efficient activation of a multitude of intracellular signaling pathways, which in turn influence a wide variety of nervous system functions, caveolin proteins are poised to act as the central coordinators of these processes.

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Section: Caveolin Proteins and Estrogen Receptorsmentioning

confidence: 84%

Caveolin proteins and estrogen signaling in the brain

Luoma

Boulware

Mermelstein

2008

Molecular and Cellular Endocrinology

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“…Third, the known effects for activity/arousal of E 2 s, which are clearly dependent upon the environmental context before and during behavioral assessment (see Morgan et al, 2004 for a review), may have influenced the present results. High circulating E 2 levels, as occurred during behavioral estrous or when E 2 is administered to ovx rodents, increase spontaneous motor activity (Joyce and Van Hartesveldt, 1984;Becker, 1990;Becker et al, 1987;Pfaff, 2001, 2002), and these effects may be ERa-specific . However, a different pattern of effects for motor activity is observed in a novel open field and/or in different lighting (see Morgan et al, 2004 for a review), and these effects in tasks involving novelty/anxiety, such as the open field, may be primarily mediated by E 2 's actions at ERb (Krezel et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Antisense Oligodeoxynucleotides for Estrogen Receptor-β and α Attenuate Estradiol's Modulation of Affective and Sexual Behavior, Respectively

Walf

Ciriza

Garcia-Segura

et al. 2007

Neuropsychopharmacol

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Estradiol (E 2 ) modulates affective and socio-sexual behavior of female rodents. E 2 's functional effects may involve actions through a and b isoforms of estrogen receptor (ERs). The importance of E 2 's actions at these isoforms for anxiety (open field, elevated plus maze), depression (forced swim test), and sexual behavior (lordosis) was investigated using an antisense oligonucleotide (AS-ODN) strategy. If ERb is required for anti-anxiety and antidepressant-like effects, and ERa is required for sexual receptivity, of E 2 , then intracerebroventricular administration of AS-ODNs against these ERs should attenuate these effects and reduce immunoreactivity of ERs in brain regions that mediate these behaviors, such as the hippocampus and ventral medial hypothalamus (VMH). Ovariectomized rats were primed with 17b-E 2 (10 mg) 48 h before testing (hour 0). At hours 0, 24, and 47.5, rats were infused with saline vehicle, scrambled control AS-ODNs, or AS-ODNs targeted against ERa and/or ERb, and were tested at hour 48. Rats infused with ERb AS-ODNs, alone, or with ERa AS-ODNs had significantly decreased open field central entries, decreased plus maze open arm time and entries, increased time spent immobile, and decreased time spent swimming in the forced swim test, and decreased ERb immunoreactivity in the brain than did rats administered ERa AS-ODNs, vehicle, or scrambled AS-ODNs. Rats that were administered ERa AS-ODNs, alone, or with ERb AS-ODNs had significantly decreased lordosis and decreased ERa immunoreactivity in the brain compared to rats administered ERb AS-ODNs, vehicle, or scrambled AS-ODNs. Thus, ERb and ERa may be required for E 2 's modulation of affective and sexual behavior, respectively.

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“…E 2 also has well known effects on activity and/or arousal of people and animals (Smith, 1994). Proestrous rats or mice, or ovx rats administered E 2 , demonstrate more spontaneous motor activity (Becker et al, 1987;Joyce and Van Hartesveldt, 1984;Morgan and Pfaff, 2002), which may disrupt performance in some behavioral tasks. As well, E 2 , particularly in the higher range of concentrations (25 mg, s.c. to mice), enhances arousal , which may influence performance.…”

Section: Discussionmentioning

confidence: 99%

ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats

Walf

Frye

2005

Neuropsychopharmacol

206

150

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17b-Estradiol (E 2 ) may influence anxiety behavior; however, its effects and mechanisms are not well understood. To determine whether E 2 's effects on anxiety behavior may involve actions at intracellular estrogen receptor (ER) a or b isoforms, selective ER modulators (SERMs) were administered (10 mg; s.c.) to ovariectomized rats 48 h before testing for anxiety behavior. Rats received sesame oil vehicle, 17b-E 2 , which has a high affinity for ERa and ERb, or SERMs that vary in their activity at ERa and b. ERa-selective SERMs were propyl pyrazole triol (PPT), which has more selective effects at ERa, than does the other ERa SERM utilized, 17a-E 2, which also binds ERb. ERbselective SERMs were diarylpropionitrile (DPN) and 7,12-dihydrocoumestan (coumestrol). DPN is more selective at ERb than coumestrol, which also binds ERa. 17b-E 2 and ERb-selective SERMs (DPN, coumestrol) produced clear antianxiety behavior in the open field, elevated plus maze, emergence, light-dark transition, defensive freezing, and Vogel punished drinking tasks. Anxiety behavior of rats administered ERa-selective SERMs (PPT, 17a-E 2 ) was not different from vehicle; however, PPT and 17a-E 2 enhanced sexual receptivity in a manner similar to 17b-E 2. Coadministration of tamoxifen (10 mg/kg) blocked the antianxiety behavior produced by 17b-E 2 , DPN, or coumestrol. Together, these data suggest that actions at ERb may underlie some of E 2 's antianxiety effects.

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The influence of estrous cycle and intrastriatal estradiol on sensorimotor performance in the female rat

Cited by 161 publications

References 39 publications

Caveolin proteins and estrogen signaling in the brain

Caveolin proteins and estrogen signaling in the brain

Antisense Oligodeoxynucleotides for Estrogen Receptor-β and α Attenuate Estradiol's Modulation of Affective and Sexual Behavior, Respectively

ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats

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