The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy

Thomason, Justin D.; Rapoport, G.; Fallaw, T.; Calvert, Clay A.

doi:10.1016/j.tvjl.2014.09.004

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Importantly, dogs receiving spironolactone in addition to conventional treatment for heart failure (loop diuretic, ACEI, and pimobendan) did not have a greater incidence of hyperkalemia. In a study of Doberman pinschers with occult DCM, significant increases in serum potassium concentration (versus individual baseline values) were seen in dogs receiving both spironolactone and an ACEI . Although the authors deemed these changes to be clinically insignificant, the serum potassium concentration exceeded the reference interval in 50% of dogs and regular monitoring of serum electrolytes and renal values (as often as every 3 months) was recommended for Doberman pinschers receiving spironolactone and ACEI.…”

Section: Suppression Of Raasmentioning

confidence: 99%

“…Overall, regular monitoring of serum electrolytes and renal values is prudent in all animals receiving vasodilators and diuretics, including spironolactone and ACEI. Finally, spironolactone in combination with an ACEI appears to be safe, when used to treat dogs with naturally occurring, asymptomatic MMVD, as well those with occult DCM, without preexisting azotemia …”

Section: Suppression Of Raasmentioning

confidence: 99%

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The renin‐angiotensin‐aldosterone system and its suppression

Ames

Atkins

Pitt

2019

Veterinary Internal Medicne

300

264

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Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic kidney disease. Excessive circulating and tissue angiotensin II (AngII) and aldosterone levels lead to a pro‐fibrotic, ‐inflammatory, and ‐hypertrophic milieu that causes remodeling and dysfunction in cardiovascular and renal tissues. Understanding of the role of the RAAS in this abnormal pathologic remodeling has grown over the past few decades and numerous medical therapies aimed at suppressing the RAAS have been developed. Despite this, morbidity from these diseases remains high. Continued investigation into the complexities of the RAAS should help clinicians modulate (suppress or enhance) components of this system and improve quality of life and survival. This review focuses on updates in our understanding of the RAAS and the pathophysiology of AngII and aldosterone excess, reviewing what is known about its suppression in cardiovascular and renal diseases, especially in the cat and dog.

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Section: Suppression Of Raasmentioning

confidence: 99%

Section: Suppression Of Raasmentioning

confidence: 99%

The renin‐angiotensin‐aldosterone system and its suppression

Ames

Atkins

Pitt

2019

Veterinary Internal Medicne

300

264

View full text Add to dashboard Cite

show abstract

“…Dogs with dilated cardiac myopathy were highly prone for kidney failure through reduced cardiac output due to systolic failure. Renal arterial and renal blood flow was reduced due to secondary effects of low cardiac output [13] . Non-significant decrease in albumin levels and no significant change in creatinine levels were observed between healthy dogs and dogs with cardiac diseases.…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological findings in dogs with cardiac diseases

Amaravathi¹,

Prebavathy²,

Rajesh³

et al. 2020

J. Entomol. Zool. Stud.

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In the present study 10,921 canine clinical cases suspected for various cardiac diseases were screened. Ten apparently healthy dogs were selected as control group and twenty seven clinical cases of dogs with various cardiac diseases were examined. In the present study there was significant (P<0.05) decrease in haemoglobin, PCV, lymphocytes and platelet count and significant (P<0.05) increase in total leukocyte count and neutrophils in dogs with cardiac diseases. Significant (P<0.05) increase in ALT, AST and BUN levels and significant (P<0.05) decrease in total protein values were noticed in dogs with cardiac diseases. Non-significant decrease in albumin levels and no significant change in creatinine levels were observed between healthy dogs and dogs with cardiac diseases. It was concluded in initial stages of cardiac diseases till cardiac renal syndrome gets deeply involved, there won't be any clinicopathological changes like haemogram, leukogram and routine biochemical changes significant for cardiac involvement.

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Antihypertensives

Cooper

2023

Small Animal Critical Care Medicine

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The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy

Cited by 5 publications

References 41 publications

The renin‐angiotensin‐aldosterone system and its suppression

The renin‐angiotensin‐aldosterone system and its suppression

Clinicopathological findings in dogs with cardiac diseases

Antihypertensives

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