The influence of embryonic mesoderm on the regional specification of epidermal derivatives in the chick

Cairns, John M.; Saunders, John W.

doi:10.1002/jez.1401270203

Cited by 119 publications

(34 citation statements)

References 14 publications

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“…It would not be unw arranted to assume that epithelization of healing wounds in the em bryo is dependent upon the composition of underlying mesoderm. This view conforms with the findings of Cairns and Saunders [1954] th at the mesoderm of the chick em bryo influences the specific developm ental perform ance of the ectoderm .…”

Section: Resultssupporting

confidence: 69%

Hexosamine and Collagen in the Developing Chick Embryo. Significance for Repair in the Adult

Rosenberg¹

1960

Cells Tissues Organs

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Section: Resultssupporting

confidence: 69%

Hexosamine and Collagen in the Developing Chick Embryo. Significance for Repair in the Adult

Rosenberg¹

1960

Cells Tissues Organs

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“…Heterotopic, heterochronic, heterospecific and heterogenetic tissue recombinations have demonstrated that the time of appearance, location, size, number and morphological identity of feathers are determined by the dermis (Cairns and Saunders, 1954;Saunders and Gasseling, 1957;Rawles, 1963;Wessells, 1965;Dhouailly, 1967;Dhouailly, 1970;Linsenmayer, 1972;Dhouailly, 1973;Dhouailly and Sawyer, 1984;Song and Sawyer, 1996;Prin and Dhouailly, 2004), but the specific cellular and molecular mechanisms through which this information is conveyed are unclear. Mesenchyme becomes competent to induce feathers at an early embryonic stage prior to any obvious morphological changes in either the mesenchyme itself or in the overlying epithelium (Widelitz et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development

2005

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The avian feather complex represents a vivid example of how a developmental module composed of highly integrated molecular and histogenic programs can become rapidly elaborated during the course of evolution. Mechanisms that facilitate this evolutionary diversification may involve the maintenance of plasticity in developmental processes that underlie feather morphogenesis. Feathers arise as discrete buds of mesenchyme and epithelium, which are two embryonic tissues that respectively form dermis and epidermis of the integument. Epithelial-mesenchymal signaling interactions generate feather buds that are neatly arrayed in space and time. The dermis provides spatiotemporal patterning information to the epidermis but precise cellular and molecular mechanisms for generating species-specific differences in feather pattern remain obscure. In the present study, we exploit the quail-duck chimeric system to test the extent to which the dermis regulates the expression of genes required for feather development. Quail and duck have distinct feather patterns and divergent growth rates, and we exchange pre-migratory neural crest cells destined to form the craniofacial dermis between them. We find that donor dermis induces host epidermis to form feather buds according to the spatial pattern and timetable of the donor species by altering the expression of members and targets of the Bone Morphogenetic Protein, Sonic Hedgehog and Delta/Notch pathways. Overall, we demonstrate that there is a great deal of spatiotemporal plasticity inherent in the molecular and histogenic programs of feather development, a property that may have played a generative and regulatory role throughout the evolution of birds.

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“…Initially, the ectoderm is induced, by signals from the mesoderm, to form the nervous system (Spemann 1938;Cairns and Saunders 1954). Recent studies have shown that particular regions of the mesoderm can induce region-specific gene expression in the developing neuroectoderm (Frohman et al 1990;Hemmati-Brivanlou et al 1990).…”

mentioning

confidence: 99%

Specific activation of mammalian Hox promoters in mosaic transgenic zebrafish.

Westerfield

Wegner²,

Jegalian³

et al. 1992

Genes Dev.

131

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Homeo box-containing genes {Hox) are expressed in restricted regions of vertebrate embryos and may specify positional information. The organization and expression patterns of these genes are highly conserved among different species, suggesting that their regulation may also have been conserved. We developed a transient expression system, using mosaically transgenic zebrafish, which allows rapid analysis of transgene expression, and examined the activities of two mammalian Hox genes, mouse Hox-1.1 and human HOX-3.3. We found that these Hox promoters are activated in specific regions and tissues of developing zebrafish embryos and that this specificity depends upon the same regulatory elements within the promoters that specify the spatial expression of these genes in mice. Our results suggest that the promoter activities have been remarkably conserved from fish to mammals. To study the regulation of Hox expression in the developing nervous system, we analyzed the promoter activities in spt-1 mutants that have a mesodermal deficiency. Our results suggest that interactions, probably with the paraxial mesoderm, differentially regulate the activities of Hox promoters in the developing nervous system.

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The influence of embryonic mesoderm on the regional specification of epidermal derivatives in the chick

Cited by 119 publications

References 14 publications

Hexosamine and Collagen in the Developing Chick Embryo. Significance for Repair in the Adult

Hexosamine and Collagen in the Developing Chick Embryo. Significance for Repair in the Adult

Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development

Specific activation of mammalian Hox promoters in mosaic transgenic zebrafish.

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