The Influence of Electric Current on Bone Regeneration in Vivo

Lavine, Leroy S.; Lustrin, Irving; Shamos, Morris H.; Moss, Melvin L.

doi:10.3109/17453677108989050

Cited by 50 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19,129,130 LIDC has also been shown to promote osteogenesis and bone growth, and improve bone fracture healing in studies with cultured cells as well as in vivo animal models. [131][132][133][134][135][136] For example, in a clinical study of 175 human patients, LIDC stimulation demonstrated solid bone union in 83.7% patients. 137 What is noteworthy is that the LIDC value used (20 μA) was of the same magnitude needed for the antimicrobial technology, and the healing rate in patients with history of osteomyelitis was 74.4%.…”

Section: Lidc-activated Technologymentioning

confidence: 99%

Nanomaterials and synergistic low‐intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Shirwaiker

Samberg

Cohen

et al. 2013

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Nanomaterials play a significant role in biomedical research and applications due to their unique biological, mechanical, and electrical properties. In recent years, they have been utilised to improve the functionality and reliability of a wide range of implantable medical devices ranging from well-established orthopaedic residual hardware devices (e.g. hip implants) that can repair defects in skeletal systems to emerging tissue engineering scaffolds that can repair or replace organ functions. This review summarizes the applications and efficacies of these nanomaterials that include synthetic or naturally occurring metals, polymers, ceramics, and composites in orthopaedic implants, the largest market segment of implantable medical devices. The importance of synergistic engineering techniques that can augment or enhance the performance of nanomaterial applications in orthopaedic implants is also discussed,, the focus being on a low intensity direct electric current (LIDC) stimulation technology to promote the long-term antibacterial efficacy of oligodynamic metal-based surfaces by ionization, while potentially accelerating tissue growth and osseointegration. While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications. The paper concludes with a discussion about some of the critical impending issues with the application of nanomaterials-based technologies in implantable medical devices, and potential directions to address these.

show abstract

Section: Lidc-activated Technologymentioning

confidence: 99%

Nanomaterials and synergistic low‐intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Shirwaiker

Samberg

Cohen

et al. 2013

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…The formation of bone by mechanical and electrical transduction is initiated by upregulation and downregulation of important signaling molecules at the cellular level. The propagation of these highly specialized signals may be facilitated by both chemical and electrical cues 48. However, problems in accurately delineating the electromagnetic mechanisms have not only been complicated by molecular and cellular complexities, but also the complexities inherent in properly defining the electric, magnetic, and pulsed combination of these energy fields 11.…”

Section: Bone: the Transducermentioning

confidence: 99%

“…The propagation of these highly specialized signals may be facilitated by both chemical and electrical cues. 48 However, problems in accurately delineating the electromagnetic mechanisms have not only been complicated by molecular and cellular complexities, but also the complexities inherent in properly defining the electric, magnetic, and pulsed combination of these energy fields. 11 The electric fields generated from both mechanical stimuli and external electrical devices exert forces on ions through the cellular membrane and interstial fluid.…”

Section: Cellular Interaction To Electrical Stimulationmentioning

confidence: 99%

Bone bioelectricity: What have we learned in the past 160 years?

Isaacson

Bloebaum

2010

J Biomedical Materials Res

View full text Add to dashboard Cite

The direct relationship between bone strain and electric fields has spurred continual interest in the field of bioelectricity over the past 160 years. It has been reported that stress-generated potentials alter cell proliferation and extracellular matrix secretion. The observation that endogenous electrical signals facilitate osteoinduction has lead to high production of electrical stimulation devices to fix bone defects. Despite the reported 100,000 nonunions healed as of 1990 with electrical stimulation, skepticism due to lack of homogeneity with trial design and dosage still exists within the scientific community. It is the purpose of this review to assess the bioelectric phenomenon of bone as it applies to piezoelectricity, fracture healing, and overall changes in bone metabolism which occur with controlled electrical stimulation.

show abstract

“…This is despite evidence in the hterathe epidemiologically determined twofold ture (Lavine et al, 1971) that fresh fracture healodds ratio for leukemia found in children that ing in animals is significantly hastened with are chronically exposed to 60-Hz, 2-A mG EM treatment. EM treatments for humans now power line magnetic intensities.…”

mentioning

confidence: 76%

Bioelectromagnetic Fields and Acupuncture

Liboff

1997

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

Possible links between bioelectromagnetism and acupuncture are explored. The current status of research activities in bioelectromagnetism is reviewed, with particular emphasis on the emerging role of the geomagnetic field in weak-field biological interactions. We suggest that experiments be designed to study the functional dependence of acupuncture on the local magnetostatic field. We also suggest revisiting the earlier work in electrobiology by Burr, Lund, Becker, and others. This type of research, establishing the likelihood of functional endogenous electric fields in biosystems, has been neglected in recent years. The continuation of such studies may be the most reasonable direction to pursue in searching out the physiological basis for acupuncture. NONTHERMAL BIOELECTROMAGNETIC olds. Some prefer to describe such athermal in-PHENOMENA teractions as subtle. Others, myself included, use weak. Whatever the word, the meaning is

show abstract

The Influence of Electric Current on Bone Regeneration in Vivo

Cited by 50 publications

References 7 publications

Nanomaterials and synergistic low‐intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Nanomaterials and synergistic low‐intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Bone bioelectricity: What have we learned in the past 160 years?

Bioelectromagnetic Fields and Acupuncture

Contact Info

Product

Resources

About