The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats

Gao, Zhenyong; Yang, Ping; Huang, Qingjun; Xu, Haiyun

doi:10.1016/j.neulet.2016.01.006

Cited by 14 publications

(4 citation statements)

References 23 publications

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“…Depression is a common psychiatric disorder, widely spread in the population, and results in decreased quality of life, and thus, treating depression is a crucial issue. 1 Although the mechanisms underlying the depression etiology remain to be elucidated, accumulating evidence support that monoamine theory is associated with depression pathophysiology. According to this theory, depression is related to reduced cerebral concentrations of one or more of the monoamines; serotonin, dopamine, and noradrenaline that are involved in maintaining psychic tone at the central level.…”

Section: Introductionmentioning

confidence: 99%

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Karam

Radwan

2020

Environmental Toxicology

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The low dose of radiation (LDR) has received growing attention for its beneficial neuroprotective effect. This study was designed to investigate the enhancing effect of LDR on the antidepressant potential of resveratrol against diazepam‐induced depression in mice. Female mice divided into five groups; control, diazepam (2 mg/kg), LDR (0.5Gy) + diazepam, resveratrol (20 mg/kg) + diazepam, LDR + resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro‐histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.

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Section: Introductionmentioning

confidence: 99%

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Karam

Radwan

2020

Environmental Toxicology

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“…In the conclusion of Munro's study, he pointed out the fact that any of such induced depression experiment should not rely on a single behavior test such as forced swimming test (FST), as this would not be sufficient to solidify a depression model [30] . Gao et al [31] observed that the rats treated with Reserpine traveled the shortest distance in comparison to the control group (saline) in the open field test. Xu et al [24] examined the depressionpain dyad in mice induced by Reserpine and found a substantial increase in the Substance P levels of the Reserpine treated groups in comparison to that in the control group.…”

Section: Observation Of Depressive Behavior and Experimental Model Tementioning

confidence: 99%

“…Hanff et al [1] , Liu et al [2] , Minor and Hanff [4] , Freitas et al [16] , Ponzio et al [18] , Arora and Chopra [22] , Li et al [32] , Sheppard and Zimmerman [46] Drug Discovery Utilizing the depletion of monoamines for a depressive model that could be reversed by potential antidepressants Liu et al [2] , Khadrawy et al [17] , Antkiewicz-Michaluk et al [21] , Xu et al [24] , Klein et al [25] , Gao et al [31] , Li et al [32] , Ozerov et al [35] , Arora et al [36] , Dhir et al [37] , Mahesh et al [38] ,…”

Section: Research Application Molecular Mechanism Relied Upon Referencesmentioning

confidence: 99%

Molecular Mechanisms and Applications of a Reserpine-Induced Rodent Model

Hedgecock¹,

Phillips²,

Ludrick³

et al. 2019

SSR-IIJLS

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Reserpine, an indole alkaloid isolated from the Rauwolfia serpentina has been around since the 1950s. This compound, used for hypertension treatment, had undesirable side effects in patients. The most notable side effect is the induction of depression. Reserpine works by binding irreversibly to the VMAT2 receptor on biogenic amine storage vesicles. This, in turn, causes the storage vesicles to leak their contents into the neuronal cytosol. Cytosolic enzymes such as monoamine oxidases then catabolize and degrade neurotransmitters including Serotonin (5-HT), Dopamine (DA), and Norepinephrine (NE). The depletion of these biogenic amines leads to an increase in depressive-like behavior in various rodents. In addition to the induction of a depressive state, traits associated with pain were also observed in rodent models. Pain is an important characteristic that is co-morbid in patients with major depressive disorder and often referred as the pain-depression dyad. The extent of the induced-depressive state can be determined by several proven tests such as the forced swimming test, open field test, and mechanical allodynia test. Reserpine also induced visible and empirical changes in rodent behavior such as akinesia, ptosis, and hypothermia to name a few. Current researches utilizing reserpine ranging from drug discovery to pathogenesis of diseases such as fibromyalgia are also summarized. Reserpine has been proved the efficacy as a suitable inducer for depression animal model to further the studies at the molecular and systemic levels.

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“…Reserpine was used as a first-line treatment for hypertension, but after chronic use, severe side effects leading to depression were observed (Guo et al, 2015). Studies have shown that this side effect is caused by the depletion of monoamines such as serotonin, dopamine, and norepinephrine (Gao et al, 2016). This evidence has been applied to animal models showing depressive symptoms, and reserpine-administered animal models are being used to study the pathological symptoms of depression (Uriguen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

Kim

Park

Seo

et al. 2021

Front. Behav. Neurosci.

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There is an urgent need to find antidepressants that can be administered for long periods without inducing severe side effects to replace conventional antidepressants that control monoamine levels, such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRI). We sought to determine the antidepressant effects of Fraxinus rhynchophylla Hance (F. rhynchophylla Hance, FX) and its components on a reserpine-induced mouse model. One hour after oral administration of FX (30, 50, and 100 mg/kg), esculin (50 mg/kg), esculetin (50 mg/kg), fraxin (50 mg/kg), and fluoxetine (20 mg/kg), reserpine was delivered intraperitoneally to mice. Behavioral experiments were conducted to measure anxiety and depressive-like behaviors after 10 days of administration. FX and its components increased the number of entries into the center of an open field as well as distance traveled within it and decreased immobility duration in the forced swim and tail suspension tests. Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α, pro-inflammatory cytokines. Finally, the diminished expressions of hippocampal phosphorylated cAMP response element-binding protein (pCREB) and brain-derived neurotrophic factor (BDNF) by reserpine were increased by FX and its components. Our results suggest that FX and its components regulate anxiety and depressive-like behaviors through stress hormones, immune regulation, and the activation of neuroprotective mechanisms, further supporting the potential of FX and its components as antidepressants.

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The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats

Cited by 14 publications

References 23 publications

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Molecular Mechanisms and Applications of a Reserpine-Induced Rodent Model

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

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