The Influence of Different Types of Diabetes on Vascular Complications

Wei, Jiahua; Tian, Jiaxing; Tang, Chengxuan; Fang, Xuefeng; Miao, Runyu; Wu, Haoran; Wang, Xiuge; Tong, Xiaolin

doi:10.1155/2022/3448618

Cited by 31 publications

(9 citation statements)

References 137 publications

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“…One of the main therapeutic objectives in patients with T1D is to obtain a stable glycemic control in order to reduce the risk of the onset of long-term micro- and macrovascular complications [ 60 , 61 , 62 ]. Stable glycemic control can be achieved via a balance between pharmacological approach and nutrition [ 63 , 64 ].…”

Section: Studies Focusing On Diets Characterized By Different Quantit...mentioning

confidence: 99%

Diet and Glycemic Index in Children with Type 1 Diabetes

et al. 2023

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In children with type 1 diabetes, a healthy lifestyle is important to control postprandial glycemia and to avoid hyperglycemic peaks that worsen the inflammatory state of vessels and tissues. Glycemic index and glycemic load are two important indexes which assess the quality and quantity of foods consumed during meals. The main macronutrients of the diet have a different effect on postprandial blood glucose levels, so it is important that diabetic children consume foods which determine a slower and steadier glycemic peak. In this review, we present the results of the most recent studies carried out in the pediatric population with T1D, whose aim was to analyze the effects of low-glycemic-index foods on glycemic control. The results are promising and demonstrate that diets promoting low-glycemic-index foods guarantee a greater glycemic stability with a reduction in postprandial hyperglycemic peaks. However, one of the main limitations is represented by the poor adherence of children to a healthy diet. In order to obtain satisfactory results, a possibility might be to ensure a balanced intake of low-, moderate- and high-glycemic-index foods, preferring those with a low glycemic index and limiting the consumption of the high- and moderate-glycemic-index types.

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Section: Studies Focusing On Diets Characterized By Different Quantit...mentioning

confidence: 99%

Diet and Glycemic Index in Children with Type 1 Diabetes

et al. 2023

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“…The number of patients globally is projected to reach 783.2 million over the next 20 years [ 1 ]. Diabetic complications include cardiovascular diseases, liver diseases, cognitive disabilities, and cancer [ 2 , 3 , 4 , 5 , 6 , 7 ]. Bone fracture risk is also elevated in diabetic patients compared to their healthy counterparts owing to reduced bone strength [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

(D-Ala2)GIP Inhibits Inflammatory Bone Resorption by Suppressing TNF-α and RANKL Expression and Directly Impeding Osteoclast Formation

Lin,

Kitaura,

Ohori

et al. 2024

IJMS

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Glucose-insulinotropic polypeptide (GIP) is an incretin hormone that induces insulin secretion and decreases blood glucose levels. In addition, it has been reported to suppress osteoclast formation. Native GIP is rapidly degraded by dipeptidyl peptidase-4 (DPP-4). (D-Ala2)GIP is a newly developed GIP analog that demonstrates enhanced resistance to DPP-4. This study aimed to evaluate the influence of (D-Ala2)GIP on osteoclast formation and bone resorption during lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. In vivo, mice received supracalvarial injections of LPS with or without (D-Ala2)GIP for 5 days. Osteoclast formation and bone resorption were evaluated, and TNF-α and RANKL expression were measured. In vitro, the influence of (D-Ala2)GIP on RANKL- and TNF-α-induced osteoclastogenesis, LPS-triggered TNF-α expression in macrophages, and RANKL expression in osteoblasts were examined. Compared to the LPS-only group, calvariae co-administered LPS and (D-Ala2)GIP led to less osteoclast formation, lower bone resorption, and decreased TNF-α and RANKL expression. (D-Ala2)GIP inhibited osteoclastogenesis induced by RANKL and TNF-α and downregulated TNF-α expression in macrophages and RANKL expression in osteoblasts in vitro. Furthermore, (D-Ala2)GIP suppressed the MAPK signaling pathway. The results suggest that (D-Ala2)GIP dampened LPS-triggered osteoclast formation and bone resorption in vivo by reducing TNF-α and RANKL expression and directly inhibiting osteoclastogenesis.

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“…Type-1 diabetes, occurs due to autoimmune-mediated destruction of the islets of Langerhans cells in the pancreas, is characterized by insulinopenia and hyperglycemia. In addition, the onset of type-1 diabetes is acute, unlike type-2 diabetes, which is characterized by a period of insulin resistance, hyperinsulinemia, and euglycemia before the onset of hyperglycemia [5,6].…”

Section: Introductionmentioning

confidence: 99%

Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

Lbn Gaol,

Sijabat,

Saragih

et al. 2024

Proceedings of the 5th International Conference on Innovation in Education, Science, and Culture, ICIESC 2023, 24 October 2023,

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This research was aimed to study the effect of ethanol extract of bosibosi leaves (Timonius flavescens) (EEBL) on histopathology of liver and cardiac muscles of diabetic male rats. Animals (25) were randomly distributed into groups of NC (normal + NaCl), DC (diabetes + NaCl), DM (diabetes + metformin), DE300 (diabetes + EEBL 300) and DE500 (diabetes + EEBL 500 mg/kg bw/day); treated for 28 consecutive days and sacrificed for tissue collection. Tissues were processed (formalin, paraffin, H & E) and examined for histopathology. All diabetic rats showed hepatic tissue necrosis which is characterized by pycnotic nuclei, karyorhexis and karyolysis. The order of groups based on the percentage tissue damage is NC ( 27.61±2.44), DM (38.62±3.87), DE500 (45.15±3.76), DE300 (61.20±5.51) and DC (75.17±3.21). Cardiac muscle shows cell damage form mild degeneration to necrosis. The results indicate the potential of EEBL to repair tissues damaged by diabetes.

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The Influence of Different Types of Diabetes on Vascular Complications

Cited by 31 publications

References 137 publications

Diet and Glycemic Index in Children with Type 1 Diabetes

Diet and Glycemic Index in Children with Type 1 Diabetes

(D-Ala2)GIP Inhibits Inflammatory Bone Resorption by Suppressing TNF-α and RANKL Expression and Directly Impeding Osteoclast Formation

Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

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