The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution

Liu, Weizhen; Zhang, Jingtao; Weiss, Pierre; Tancret, Franck; Bouler, Jean‐Michel

doi:10.1016/j.actbio.2012.11.020

Cited by 64 publications

(41 citation statements)

References 57 publications

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“…The reinforcement mechanism provided by alginate could be due to a crack bridging effect, similarly to what proposed by [47] in the case of cellulose-containing CPCs. …”

Section: Discussionsupporting

confidence: 58%

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

et al. 2016

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The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

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“…The reinforcement mechanism provided by alginate could be due to a crack bridging effect, similarly to what proposed by [47] in the case of cellulose-containing CPCs. …”

Section: Discussionsupporting

confidence: 58%

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

et al. 2016

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“…An explanation for the relatively high amounts of CPC/PLGA material remnants could be the use of CMC in this study. To promote cohesion and improve injectability as well as washing resistance, previous studies have shown that addition of cellulose‐based lubricants can be used . Recent work by An et al who also used CMC to enhance injectability of CPC and filled defects created in rabbit femoral condyles, showed corroborating degradation data.…”

Section: Discussionmentioning

confidence: 81%

The performance of CPC/PLGA and Bio‐Oss^® for bone regeneration in healthy and osteoporotic rats

et al. 2016

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Abstract:The current study aimed to evaluate the biological performance of calcium phosphate cement (CPC) with polylactic-co-glycolic acid (PLGA) micro-particles and Bio-Oss V R in ovariectomized and healthy rats. Thirty-two Wistar rats received alternating experimental CPC/PLGA and Bio-Oss V R in femoral condyle defects in both femurs 6 weeks after ovariectomy (OVX, n 5 16) or sham operation (SHAM, n 5 16). Six weeks after OVX or SHAM surgery, bone morphology was analyzed by in vivo computed tomography (CT) to confirm osteoporotic bone condition. Analysis of bone formation and material remnants at 4 and 12 weeks after material implantation was performed by micro-CT, descriptive histology, histomorphometry and bone dynamics by fluorochrome labeling. The in vivo CT scans showed effective induction of osteoporotic bone condition by ovariectomy. Our data showed CPC/ PLGA degraded relatively faster and more steadily. However, Bio-Oss V R had significantly less material remnants and showed significantly more bone formation compared to CPC/ PLGA. Overall, our data showed relatively high amounts of CPC/PLGA for each time point, hampering new bone formation within the defect area. Osteoporotic conditions proved to significantly affect degradation rates, but did not significantly influence bone formation. An osteoporotic bone condition affects degradation of CPC/PLGA, which is vital information for its potential use in osteoporotic conditions.

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“…They have great design flexibility, owing to their composition, and their structure can be tailored to a specific need [39]. Several studies on bone tissue engineering using polysaccharides such as alginate, carrageenan, chitosan, pullulan or cellulose [40][41][42][43][44][45] are in progress. These natural polymers hold promise for healing and regenerating damaged tissues, since they are highly permeable and facilitate the transport of nutrients and metabolites [46].…”

Section: Introductionmentioning

confidence: 99%

Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis

Guerrero¹,

Catros²,

Derkaoui³

et al. 2013

Acta Biomaterialia

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The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution

Cited by 64 publications

References 57 publications

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

The performance of CPC/PLGA and Bio‐Oss^® for bone regeneration in healthy and osteoporotic rats

Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis

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The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution

Cited by 64 publications

References 57 publications

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

The performance of CPC/PLGA and Bio‐Oss® for bone regeneration in healthy and osteoporotic rats

Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis

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The performance of CPC/PLGA and Bio‐Oss^® for bone regeneration in healthy and osteoporotic rats