The Influence of Dietary Restrictions and Malnutrition on Morphological Construction of Bone Marrow

Abstract

Well-balanced diet impacts on nutritional status. It is an important factor which determines proper forming of haematopoietic cells of bone marrow. Deficit as well as excess of diet components or calories can disturb functions of bone marrow and cause development of many diseases, including anaemia. The review of actual knowledge on the influence of dietary restrictions and malnutrition on functions of haematopoietic stem cells and erythrogenesis has been done in this paper. It was conducted many researches related to changes in animal's peripheral blood with limited caloric intake, but only some of them referred to the influence of malnutrition on bone marrow haematopoiesis. Malnutrition and commonly tested lack of protein in diet can cause hypoplasia and impaired immune function. Moderate caloric restrictions which do not cause malnutrition can contribute to slow down in ageing and to prevent chronic diseases. The composition of diet and its influence on morphological construction of bone marrow is little known issue with high innovative potential. In view of wide usage of animal model in assessment of drug safety, it should be considered to explore this knowledge and conduct additional researches.

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