The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants

Axelsson, Inge; Flodmark, Carl‐Erik; Räihä, Niels C. R.; Tacconi, M.T.; Visentin, Mario; Minoli, I; Moro, Guido; Warm, Aleksander

doi:10.1111/j.1651-2227.1997.tb08927.x

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…Our trial showed that supplementation of infant formula with 33.5 mg/L (5 mg/100 kcal) free NT did not influence the FA status of term infants at 7 mon of age. Our results support the findings of Hernell and Lön-nerdal (14), Woltil et al (13), and Axelsson et al (12) but contrast with the frequently cited studies from Spain suggesting that dietary NT may play a role in enhancing enzymes involved in the conversion of 18-carbon PUFA precursors to their longer-chain derivatives (10,11,22). The Spanish studies report higher levels of LCPUFA in erythrocyte phospholipids, plasma lipids, and plasma phospholipids in the NT-supplemented group of infants compared with unsupplemented infants in the first months of life.…”

Section: Discussionsupporting

confidence: 95%

“…An area of controversy in NT nutrition relates to their ability to modulate the accumulation of long-chain PUFA (LCPUFA), such as DHA (22:6n-3) and arachidonic acid (20:4n-6) (10,11). Whereas reports from one laboratory suggest beneficial effects, subsequent studies involving preterm (12) or low-birth-weight infants (13) have been unable to confirm the LCPUFA-enhancing effects of supplemental NT compared with unsupplemented formula. In a more recent study designed primarily to examine the effect of added NT on iron status of term infants, there was also no significant difference between the NT-supplemented group and other formula groups in erythrocyte FA composition at both time points following commencement of feeding (4 and 6 mon of age) (14).…”

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confidence: 94%

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Dietary nucleotides do not alter erythrocyte long‐chain polyunsaturated fatty acids in formula‐fed term infants

Gibson

Hawkes

Makrides

2005

Lipids

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There have been conflicting reports regarding the effectiveness of dietary nucleotides (NT) to regulate tissue desaturases and hence stimulate accumulation of both n-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFA). The aim of this study was to examine the effect of NT-supplemented cow's milk-based formula on erythrocyte phospholipid FA status in a large randomized controlled trial involving a well-nourished infant population born at term. Formula-fed infants were allocated to control formula with an innate level of NT at 10 mg/L (n = 102), or formula fortified with NT at 34 mg/L (n = 98). A parallel group of breastfed infants was included as a reference. Peripheral blood samples were collected by venipuncture at 7 mon of age and erythrocyte phospholipid FA determined by capillary GC. Erythrocyte LCPUFA levels did not differ between the NT-supplemented and control formula groups and were reduced in both groups compared with breastfed infants. We conclude that there is no induction of LCPUFA accumulation in erythrocyte phospholipids of term, formula-fed infants following 7 mon of NT supplementation.

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Section: Discussionsupporting

confidence: 95%

mentioning

confidence: 94%

Dietary nucleotides do not alter erythrocyte long‐chain polyunsaturated fatty acids in formula‐fed term infants

Gibson

Hawkes

Makrides

2005

Lipids

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“…Exogenous nucleotides are considered as conditional nutrients (Van Buren and Rudolph, 1997). Dietary nucleotides have beneficial effects upon small intestinal growth and development (Uauy, 1990; Iijima et al., 1993; Tanaka et al., 1996), lipid metabolism (Boza et al., 1992; Sato et al., 1995; Axelsson et al., 1997) and hepatic function (Lopez‐Navarro et al., 1996; Pérez et al., 2004).…”

Section: Introductionmentioning

confidence: 99%

Dietary nucleotides protect thymocyte DNA from damage induced by cyclophosphamide in mice

Wang

Gong

et al. 2007

Animal Physiology Nutrition

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The effects of dietary nucleotides on thymocyte DNA damages induced by cyclophosphamide (CP) in mice were examined. First, phase I experiment was conducted to determine the optimal timing of detecting thymocyte DNA damages induced by CP (150 mg/kg body weight) in mice. Thymocyte DNA damages was determined at 6, 12, 18, 24 h by single-cell gel electrophosphoresis assay (comet assay) after intraperitoneal injection of CP. The levels of DNA damage at 6, 12, 18, 24 h were all significantly higher than that of the control group (p < 0.01). The highest level of DNA damage appeared at 18 h and then decreased at 24 h. Therefore, 18 h was selected to determine DNA damages induced by CP in subsequent experiments. In phase II experiment, 30 male KunMing mice were divided into three treatments: negative control (NC), positive control (PC) and nucleotides group (NG). Mice in NC and PC were fed nucleotide-free diet, and mice in NG were fed nucleotide-supplemented diet (supplemented with 0.25% nucleotides, a mixture containing equal amounts of AMP, CMP, GMP and UMP). Mice in PC and NG groups were injected with CP (150 mg/kg body weight) at 21 days. DNA damage in thymocytes was evaluated at 18 h after CP treatment. The results indicate that dietary nucleotides do not affect the weights of the thymus and the spleen, or their organ indices (p > 0.05), but significantly decrease the percentage of comet cells and comet tail sizes (p < 0.01). This study demonstrates that dietary nucleotides could reduce the level of thymocyte DNA damage induced by CP in mice.

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“…Efetivamente, estes são considerados ingredientes funcionais com papel na síntese de DNA e RNA e provável ação imunológica, bem como no aumento da biodisponibilidade do ferro, na modificação favorável da microbiota intestinal e no metabolismo das lipoproteínas. [39][40][41][42][43][44] A suplementação com vitamina D durante o primeiro ano de vida, quer nos lactentes alimentados com leite materno quer nos que são alimentados com fórmulas infantis, reuniu consenso, o qual é concordante com as recomendações da Comissão de Nutrição da ESPGHAN. 45 Também houve consenso quanto à maior disponibilidade do cálcio no leite humano comparativamente às fórmulas infantis e à importância da relação Ca/P nestas para a otimização da sua absorção.…”

Section: Discussionunclassified

CoFI - Consenso Sobre Fórmulas Infantis: A Opinião de Peritos Portugueses sobre a Sua Composição e Indicações

2018

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Introduction: Breastfeeding has unique health benefits. Exclusive breastfeeding is recommended during the first six months of life and should be maintained during complementary feeding. Alternatively, infant formulas, which are designed to mimic human breastmilk to promote similar metabolic and growth profiles, can be used. This study aimed to assess the opinion of Portuguese paediatricians with expertise in nutrition on the composition, benefits and indications of commercialised infant formulas.Material and Methods: A survey based on the Delphi method with application of a questionnaire developed by a scientific committee was issued to a panel of paediatricians with expertise in nutrition. An initial questionnaire that included 65 items covering 11 areas was administered in two rounds.Results: Twenty-one experts participated, and the final response rate was 87.5%. The panel was in agreement in 68.3% of the enquired items, namely that infant formulas should be used only when breastfeeding is not possible. Notwithstanding, the opinion of the panel was heterogeneous on a number of issues, particularly those related to the advantages and indications of ‘special’ or modified infant formulas (partially hydrolysed formulas and anti-colic, anti-constipation and anti-regurgitation formulas) and of young child formulas (‘growing-up formulas’).Discussion: A wide consensus was recorded on the nutritional quality, food safety and indications attributed to commercialized infant formulas.Conclusion: The opinion of Portuguese experts was consensual in most of the enquired topics. The absence of consensus was mostly related to issues that remain under debate in the literature and lack robust scientific evidence.

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The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants

Abstract: These results do not suggest an effect of nucleotides on the red blood cell LC-PUFA profile in preterm infants. However, the nucleotides may increase the concentrations of triglycerides in plasma.

Cited by 14 publications

References 27 publications

Dietary nucleotides do not alter erythrocyte long‐chain polyunsaturated fatty acids in formula‐fed term infants

Dietary nucleotides do not alter erythrocyte long‐chain polyunsaturated fatty acids in formula‐fed term infants

Dietary nucleotides protect thymocyte DNA from damage induced by cyclophosphamide in mice

CoFI - Consenso Sobre Fórmulas Infantis: A Opinião de Peritos Portugueses sobre a Sua Composição e Indicações

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