The Influence of Diabetes on Degree of Abdominal Aortic Aneurysm Tissue Inflammation

Arapoglou, Vassilis; Kondi-Pafiti, Agathi; Rizos, Demetrios; Carvounis, Eleni; Frangou-Plemenou, Matrona; Kotsis, Thomas; Katsenis, K

doi:10.1177/1538574410363748

Cited by 10 publications

(15 citation statements)

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“… 34–36 In contrast, a higher macrophage infiltration was observed in AAA wall of diabetic compared to non-diabetic patients who underwent AAA surgical repair and was correlated with serum glucose concentration. 79 AAA diameter was similar between diabetics and non-diabetics, and no significant difference was observed for T-lymphocyte infiltration. The discrepancy between those human and animal studies underlines the complex impact of diabetes on inflammation and suggests that the protective effect of DM on AAA development and progression may not be linked to its impact on inflammatory pathways ( Figure 1 ).…”

Section: Mechanistic Effects Of Diabetes On Aortic Aneurysmmentioning

confidence: 70%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

127

102

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Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only curative treatment available relies on surgical approaches; drug-based therapies are lacking, highlighting an unmet need for clinical practice. Abdominal aortic aneurysm (AAA) is frequently associated with atherosclerosis and cardiovascular risk factors including male sex, age, smoking, hypertension, and dyslipidaemia. Thoracic aortic aneurysm (TAA) is more often linked to genetic disorders of the extracellular matrix and the contractile apparatus but also share similar cardiovascular risk factors. Intriguingly, a large body of evidence points to an inverse association between diabetes and both AAA and TAA. A better understanding of the mechanisms underlying the negative association between diabetes and aortic aneurysm could help the development of innovative diagnostic and therapeutic approaches to tackle the disease. Here, we summarize current knowledge on the relationship between glycaemic parameters, diabetes, and the development of aortic aneurysm. Cellular and molecular pathways that underlie the protective effect of diabetes itself and its treatment are reviewed and discussed, along with their potential implications for clinical translation.

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Section: Mechanistic Effects Of Diabetes On Aortic Aneurysmmentioning

confidence: 70%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

127

102

View full text Add to dashboard Cite

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“…Most of the studies published so far compared features between diabetic and non-diabetic patients with AAA ( 19 , 30 - 34 ). To the best of our knowledge, this is the first study addressing the association between insulin resistance and AAA.…”

Section: Discussionmentioning

confidence: 99%

Association of abdominal aortic aneurysm diameter with insulin resistance index

Lareyre¹,

Moratal

Zereg³

et al. 2018

Biochemia Medica

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IntroductionEpidemiological studies have highlighted a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to investigate the association between insulin resistance and AAA size.Materials and methodsThis prospective cross sectional monocentric study analysed fasting blood samples from 55 patients with AAA eligible for surgical repair. They were divided into 2 groups according to the median AAA diameter: diameter < 50 mm (N = 28) and diameter > 50 mm (N = 27). The median ages were respectively 73 years (62 - 79) and 72 years (67 - 81). Glucose and fructosamine concentrations were determined by spectrophotometry; insulin and C-peptide using chemiluminescent technology. Homeostasis model assessment 2 calculator was used to estimate insulin resistance index (HOMA2 IR).ResultsThere was no significant difference for fasting glucose concentration between the groups (6.1 vs. 5.9 mmol/L, P = 0.825). C-peptide and insulin concentrations, as well as HOMA2 IR index were significantly higher in patients with AAA > 50 mm (0.82 vs. 0.54 nmol/L, P = 0.012; 9 vs. 5 mU/L, P = 0.019 and 1.72 vs. 1.26, P = 0.028, respectively). No linear correlation was identified between AAA diameter and HOMA2 IR. Fructosamine concentration was lower in patients with AAA > 50 mm (225.5 vs. 251 μmol/L, P = 0.005) and negatively correlated with AAA diameter (r = - 0.54, P < 0.001).ConclusionThis study evidenced an association between AAA diameter and insulin resistance. Further studies are required to determine a causal link between insulin resistance and AAA development.

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“…32 DM is known to induce vascular inflammation in atherosclerotic tissues; 33,34 however, some studies also suggest that a similar phenomenon occurs among aneurysmal tissues which would seem inappropriate given the relationship between DM and AAA. 35 Indeed, Arapoglou et al 35 examined macrophage levels in patients undergoing open AAA repair and found significantly higher levels in aortic tissues from patients with DM compared to those without (p = 0.02) and a positive correlation with serum glucose levels (r = 0.21, p = 0.04).…”

Section: Inflammationmentioning

confidence: 99%