The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients

Kusztal, Mariusz; Kościelska‐Kasprzak, Katarzyna; Drulis−Fajdasz, Dominika; Magott-Procelewska, Maria; Patrzałek, D.; Janczak, Dariusz; Chudoba, P.; Klinger, Marian

doi:10.1016/j.trim.2010.05.002

Cited by 40 publications

(43 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the combination (+49)AA/(AT)LL haplotype (where L=low AT repeat number) was associated to better allograft function than the GG/HH haplotype (where H=high ,i.e. >82-bp repeats) (Kusztal et al, 2010).…”

Section: Discussionmentioning

confidence: 90%

“…The (+6230) A/G polymorphism (or CT60) in the 3'untraslated region (UTR) of the CTLA-4 gene (rs3087243) has been shown to be associated with the mRNA level of soluble CTLA-4. This later SNP was associated with the levels of membrane and cytoplasmic CTLA-4 in CD4 T lymphocytes from multiple sclerosis patients and with the variation of serum soluble CTLA-4 level in Graves' disease patients (Kusztal et al, 2010). Also in the 3'UTR of CTLA-4 gene, a microsatellite (AT)n has been identified at position 642.…”

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 92%

“…The (+49) A allele had been identified as protective, whereas the G allele was associated with greater susceptibility to autoimmune diseases (Liu et al, 2010). A single nucleotide polymorphism (SNP) at position (-318) C/T in the promoter region (rs5742909) influences promoter activity and the expressions of both CTLA-4 mRNA in un-stimulated cells and cell-surface CTLA-4 on activated cells (Kusztal et al, 2010). The (+6230) A/G polymorphism (or CT60) in the 3'untraslated region (UTR) of the CTLA-4 gene (rs3087243) has been shown to be associated with the mRNA level of soluble CTLA-4.…”

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 99%

“…The variation in the number of the dinucleotide (AT) repeat is associated with the stability of mRNA transcripts (Liu, 2010). It has been established that a low number of (AT) repeats is responsible for favorable mRNA stability, which results in lower T cell proliferation (Kusztal et al, 2010). For the CD28 gene, a T/C SNP at position (+17) of the intron 3 (rs3116496) or IVS3 (+17) is identified.…”

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients

Krichen¹,

Sfar²,

Abdallah³

et al. 2011

Kidney Transplantation - New Perspectives

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 90%

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 92%

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 99%

Section: Polymorphisms In the Ctla-4 Cd28 And Cd86 Genesmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients

Krichen¹,

Sfar²,

Abdallah³

et al. 2011

Kidney Transplantation - New Perspectives

View full text Add to dashboard Cite

“…Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role for CTLA-4 (Tivol et al, 1995). Several reports strongly suggest that molecular variants in CTLA-4 are involved in T-cell-mediated autoimmune and inflammatory diseases such as type 1 diabetes, autoimmune thyroid disease, multiple sclerosis, systemic lupus erythematosus, and RA (Scalapino et al, 2008;Kusztal et al, 2010;Liu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China

Liu

Jiang²,

Wang³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated the genetic association of CTLA-4 and CD86 polymorphisms with RA in a Chinese population. Four single nucleotide polymorphisms (SNPs) (rs5742909 and rs231775 in CTLA-4, and rs17281995 and rs1129055 in CD86) were genotyped in 213 patients with RA and 303 healthy controls using polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele distributions of rs5742909 differ significantly between RA patients and controls (P < 0.05) and the dominant model was found to be the best inheritance model. Stratification studies showed that CTLA-4 gene polymorphisms were more significantly associated with rheumatoid factor-negative and anti-cyclic citrullinated peptide-negative subgroups in the southeastern Han Chinese population. We also found that the haplotype of 2 CTLA-4 SNPs showed significant association with the disease (P = 0.0025) with the T-A (OR = 1.88, 95%CI = 1.12-3.15) and T-G (OR = 3.45, 95%CI = 1.10-10.87) haplotypes being observed more frequently in cases than in controls. We failed to find any significant association of the 2 CD86 SNPs with RA. These results indicate that the polymorphisms of CTLA-4 (rs5742909) may be important genetic factors for RA risk in the southeastern Han Chinese population.

show abstract

Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and acute rejection risk in transplant recipients

et al. 2012

View full text Add to dashboard Cite

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene polymorphisms have been reported to influence the risk for acute rejection (AR) in transplant recipients. However, the results still remain controversial and ambiguous. The objective of the current study was to conduct a meta-analysis investigating the association between polymorphisms in the CTLA-4 gene and the risk of AR in transplant recipients. Electronic searches for all publications were conducted on associations between this variant and acute rejection in Medline and Embase databases through November 2011. Crude odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to estimate the strength of the association. Three polymorphisms (+49 adenine/guanine [+49A/G], -318 cytosine/thymine [-318C/T], and the +6230G/A polymorphism [CT60]) in 18 case-control studies from ten articles were analyzed. This meta-analysis included 2,081 cases of transplant recipients in which 813 cases developed AR and 1,268 cases did not develop AR. The results indicated that there was no statistically significant association between the risk of AR and the +49A/G polymorphism or the -318C/T polymorphism (+49A/G: OR = 0.876, 95 % CI = 0.650-1.180 for GG vs. AA; OR = 1.121, 95 % CI = 0.911-1.379 for AG + GG vs. AA; -318C/T: OR = 0.397, 95 % CI = 0.138-1.143 for TT vs. CC; OR = 0.987, 95 %CI = 0.553-1.760 for CT + TT vs. CC). However, individuals who carried CT60 A allele might have a decreased risk of AR (AA vs. GG OR = 0.535, 95 % CI = 0.340-0.841, A vs. G OR = 0.759, 95 % CI = 0.612-0.914) in liver transplant recipients among Europeans, but because only two studies were included, so the result should be caution. In further stratified analyses for the +49A/G and the -318C/T polymorphisms, no obvious significant associations were found in subgroups of renal transplant recipients and Europeans, a reduced incidence of acute rejection was observed in liver transplant recipients that are homogenous for +49G (OR = 0.638, 95 % CI = 0.427-0.954 for GG vs. AA/AG), while this has not been observed in renal transplant recipients. Overall this meta-analysis suggests that +49A/G and the -318C/T polymorphisms in CTLA-4 may be not associated with the risk of rejection after organ transplantation, but CTLA +49A/G and +6230G/A polymorphisms may be associated with acute rejection after liver transplantation, not after renal transplantation. In future, more studies should be included to evaluate the association between +6230G/A polymorphism and AR risk.

show abstract

The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients

Cited by 40 publications

References 20 publications

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients

CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China

Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and acute rejection risk in transplant recipients

Contact Info

Product

Resources

About