Abstract:The influence of cross-linking upon the kinetics of fibrinolysis has been studied in an in vitro system by monitoring the release of radioactive label, peptide materials, fragment X and D-dimer. Cross-linked (XL) and non-cross-linked (NXL) fibrin clots were prepared by clotting citrated plasma containing 125-I labelled fibrinogen with human thrombin, in the presence respectively of 40 mM Ca C12 or 2 mM EDTA, and incubating for 2 hours at 37°C. After washing, clots were placed in buffer containing human plasmin… Show more
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