The influence of cooling and TRPM8 ion channel activation on the level of pro-inflammatory cytokines in normotensive and hypertensive rats

Козырева, Т. В.; Khramova, G. M.; Voronova, Irina P.; Evtushenko, A. A.

doi:10.1016/j.jtherbio.2016.09.004

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…During wound healing, monocytes arrive at the wound site and turn into macrophages, releasing several inflammatory mediators and cytokines, and producing ROS. TNF-α, IL-1β, and IL-6 are inflammatory cytokines that play significant roles in the inflammatory process during skin wound healing because they coordinate actions of different types of cells [38]. Secreted cytokines induce chemokines of chemotaxis, attracting immune cell to the site of the injury, contributing to skin repair and homeostasis [45].…”

Section: Discussionmentioning

confidence: 99%

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The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

et al. 2021

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Wound healing involves inflammatory, proliferative, and remodeling phases, in which various cells and chemical intermediates are involved. This study aimed to investigate the skin wound healing potential of menthol, as well as the mechanisms involved in its effect, after 3, 7, or 14 days of treatment, according to the phases of wound healing. Skin wound was performed in the back of Wistar rats, which were topically treated with vehicle cream; collagenase-based cream (1.2 U/g); or menthol-based cream at 0.25%, 0.5%, or 1.0% over 3, 7, or 14 days. Menthol cream at 0.5% accelerated the healing right from the inflammatory phase (3 days) by decreasing mRNA expression of inflammatory cytokines TNF-α and Il-6. At the proliferative phase (7 days), menthol 0.5% increased the activity of antioxidant enzymes SOD, GR, and GPx, as well as the level of GSH, in addition to decreasing the levels of inflammatory cytokines TNF-α, IL-6, and IL-1β and augmenting mRNA expression for Ki-67, a marker of cellular proliferation. At the remodeling phase (14 days), levels of inflammatory cytokines were decreased, and the level of Il-10 and its mRNA expression were increased in the menthol 0.5% group. Menthol presented skin wound healing activity by modulating the antioxidant system of the cells and the inflammatory response, in addition to stimulating epithelialization.

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Section: Discussionmentioning

confidence: 99%

“…Cytokines are messenger molecules of the immune system that perform the interaction between immune, nervous, and endocrine systems; several cytokines are involved in the skin wound healing process [38]. After three days of treatment, the levels of cytokines were not different among groups.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

et al. 2021

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“…To date, TRPM8 has not been linked to skin homeostasis or dermatitis ( Caterina, 2014 ). However, its activation can suppress chemically evoked irritation and inhibit TRPV1-mediated CGRP release in colon tissue ( Ramachandran et al, 2013 ), and can also induce an increase in the level of some proinflammatory cytokines in the blood of normotensive rats ( Kozyreva et al, 2016 ).…”

Section: Calcium-sensing Receptors and Channels Mediated Ca 2+ Signaling In Skin Function Maintenancementioning

confidence: 99%

Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases

Wang

et al. 2021

Front. Pharmacol.

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Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series of dermatologic diseases. A large variety of biological events and bioactive molecules are involved in the process of skin wound healing and functional recovery. Calcium ions (Ca2+) released from intracellular stores as well as influx through plasma membrane are essential to skin function. Growing evidence suggests that calcium influx is mainly regulated by calcium-sensing receptors and channels, including voltage-gated, transient potential receptor, store-operated, and receptor-operated calcium channels, which not only maintain cellular Ca2+ homeostasis, but also participate in cell proliferation and skin cell homeostasis through Ca2+-sensitive proteins such as calmodulin (CaM). Furthermore, distinct types of Ca2+ channels not merely work separately, they may work concertedly to regulate cell function. In this review, we discussed different calcium-sensing receptors and channels, including voltage-gated, transient receptor potential, store-operated, and receptor-operated calcium channels, particularly focusing on their regulatory functions and inherent interactions as well as calcium channels-related reagents and drugs, which is expected to bridge basic research and clinical applications in dermatologic diseases.

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“…Some inflammatory regulatory molecules showed variable changes during PRRSV infection. The expression levels of genes encoding PLA2G6, LOX, TRPV1, ASIC1, GSG2, TRPM8 (Kozyreva et al 2016) and TRPM4 were significantly up-regulated during PRRSV ? IgGinfection, while the expression levels of those cytokines showed a more significant down-regulation under PRRSV ?…”

Section: Regulation Of Inflammation By Porcine Fceri In Prrsv Infectionmentioning

confidence: 99%

Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction

et al. 2018

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Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study, the expression of different Fc receptors (FcRs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of FcγII and FcεRI was significantly up-regulated under PRRSV-antibody complex infection. Internalization and proliferation of PRRSV were promoted by the ADE mechanism when FcεRI was expressed in permissive 3D4/21 cells and the non-permissive cell line HEK 293T. Transcriptome sequencing data showed that the expression levels of AKT, ERK and other signal molecules in the anti-inflammatory pathway were significantly increased, especially in the cells infected with the PRRSV-antibody immune complex. Inflammatory regulatory molecules such as PLA2G6, LOX, TRPM8 and TRPM4 were significantly up-regulated following PRRSV infection but significantly down-regulated in the cells infected with the PRRSV-antibody immune complex. Our results demonstrated that FcεRI could be involved in PRRSV ADE, the antigen presenting process and regulation of the inflammatory response during PRRSV infection, which provides new insights into PRRSV infection mediated by FcεRI and the PRRSV-antibody immune complex.

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The influence of cooling and TRPM8 ion channel activation on the level of pro-inflammatory cytokines in normotensive and hypertensive rats

Cited by 12 publications

References 31 publications

The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases

Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction

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