The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia

Hooker, Christine I.; Bruce, Lori; Fisher, Melissa; Verosky, Sara C.; Miyakawa, Asako; D’Esposito, Mark; Vinogradov, Sophia

doi:10.1016/j.pscychresns.2013.04.001

Cited by 55 publications

(59 citation statements)

References 54 publications

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“…The social deficits observed here suggest our PS offspring model some aspects of neurodevelopmental disorders such as ASDs and schizophrenia. In support of this notion, amygdala responses to social and emotional stimuli are dampened in schizophrenia patients (Rasetti et al, 2009), and treatments that remediate this activity deficit are more effective (Hooker et al, 2013). The anxiolytic effect of PS may reflect generally dampened emotionality, and may in fact be parsimonious with reduced sociability.…”

Section: Discussionmentioning

confidence: 96%

Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats

Ehrlich

Rainnie

2015

Neuropsychopharmacol

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Prenatal stress (PS) is a risk factor for neurodevelopmental disorders with diverse ages of onset and socioemotional symptoms. Some PS-linked disorders involve characteristic social deficits, such as autism spectrum disorders and schizophrenia, but PS also promotes anxiety disorders. We propose the diversity of symptoms following PS arises from perturbations to early brain development. To this end, we characterized the effects of PS on the developmental trajectory of physiology of the amygdala, a late-developing center for socioemotional control. We found that PS dampened socioemotional behavior and reduced amygdala neuron excitability in offspring during infancy (at postnatal days (P)10, 14, 17 and 21), preadolescence (day 28), and adulthood (day 60). PS offspring in infancy produced fewer isolation-induced vocalizations and in adulthood exhibited less anxiety-like behavior and deficits in social interaction. PS neurons had a more hyperpolarized resting membrane potential from infancy to adulthood and produced fewer action potentials. Moreover, adult amygdala neurons from PS animals expressed larger action potential afterhyperpolarizations and H-current relative to controls, further limiting excitability. Our results suggest that PS can suppress socioemotional behavior throughout development and produce age-specific alterations to amygdala physiology.

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Section: Discussionmentioning

confidence: 96%

Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats

Ehrlich

Rainnie

2015

Neuropsychopharmacol

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“…To summarize, when comparing chronically ill people with schizophrenia to healthy controls, only two of the 22 studies that examined sex differences provided evidence that women with schizophrenia outperform men on FEP tasks. From our PubMed search of more recent studies not included in the meta-analyses, a total of 16 of the 20 studies that examined adults with chronic schizophrenia either did not report on sex differences or controlled for sex in their FEP analyses [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] , with one study including an all-male sample [68] . Of the remaining four studies, three studies did not find sex differences on an FEP identification task [69][70][71] .…”

Section: Adults With Chronic Schizophreniamentioning

confidence: 99%

Facial emotion perception in schizophrenia: Does sex matter?

Mote

Kring

2016

WJP

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AIM:To review the literature on sex differences in facial emotion perception (FEP) across the schizophrenia spectrum. METHODS:We conducted a systematic review of empirical articles that were included in five separate meta-analyses of FEP across the schizophrenia spectrum, including meta-analyses that predominantly examined adults with chronic schizophrenia, people with early (onset prior to age 18) or recent-onset (experiencing their first or second psychotic episode or illness duration less than 2 years) schizophrenia, and unaffected first-degree relatives of people with schizophrenia. We also examined articles written in English (from November 2011 through June 2015) that were not included in the aforementioned metaanalyses through a literature search in the PubMed database. All relevant articles were accessed in full text. We examined all studies to determine the sample sizes, diagnostic characteristics, demographic information, methodologies, results, and whether each individual study reported on sex differences. The results from the meta-analyses themselves as well as the individual studies are reported in tables and text. RESULTS:We retrieved 134 articles included in five separate meta-analyses and the PubMed database that examined FEP across the schizophrenia spectrum. Of these articles, 38 examined sex differences in FEP. Thirty of these studies did not find sex differences in FEP in either chronically ill adults with schizophrenia, early-onset or recently diagnosed people with schizophrenia, or first-degree relatives of people with schizophrenia. Of the eight studies that found sex differences in FEP, three found that chronically ill women outperformed men, one study found that girls with early-onset schizophrenia outperformed boys, and two studies found that women (including first-degree relatives, adults with schizophrenia, and the healthy control group) outperformed men on FEP tasks. In total, six of the eight studies that examined sex differences in FEP found that women outperformed men across the SYSTEMATIC REVIEWS Core tip: People with schizophrenia exhibit deficits in facial emotion perception (FEP) compared to healthy controls. These deficits are associated with poorer functioning and more severe symptoms. Although the literature to date suggests that there are few sex differences in FEP in schizophrenia, continued assessment of sex differences in FEP can help researchers and clinicians better understand other sex differences in the disorder and assist in treatment development aimed at improving functioning in people with schizophrenia. This review summarizes and critically evaluates the literature on FEP across the schizophrenia spectrum, focusing on the evidence related to sex differences in FEP.Mote J, Kring AM. Facial emotion perception in schizophrenia: Does sex matter? World J Psychiatr 2016; 6(2): 257-268

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“…A few recent studies (Frommann et al, 2003; Russell et al, 2006; Sacks et al, 2013; Wolwer et al, 2005; Hooker et al, 2012; Hooker et al, 2013) tested computerized training of facial affect recognition and mental state decoding in chronic patients, with promising results in emotion perception, management and social functioning (Kurtz and Richardson, 2012). These results in chronic patients show that improving social cognition and social skills using a single-user, computer-based intervention is feasible and is potentially beneficial.…”

Section: Introductionmentioning

confidence: 99%

A novel, online social cognitive training program for young adults with schizophrenia: A pilot study

Nahum

Fisher

Loewy

et al. 2014

Schizophrenia Research: Cognition

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Background Pervasive social cognition deficits are evident early in the course of schizophrenia and are directly linked to functional outcome, making them an important target for intervention. Here, we tested the feasibility of use, and initiated the evaluation of efficacy, of a novel, neuroplasticity-based online training program (SocialVille) in young adults with schizophrenia. Methods Schizophrenia patients (n=17) completed 24 hours of online SocialVille game play either from home or at a clinic, over a 6-10 week period. We examined training feasibility, gains on the SocialVille exercises relative to matched healthy controls (n=17), and changes on measures of social cognition, social functioning, global functioning and motivation. Results Subjects adhered to training requirements, and rated SocialVille in the medium to high range in satisfaction, enjoyment, and ease of use. Subjects demonstrated significant, large improvements on the speeded SocialVille tasks, and small to moderate improvements on the working memory tasks. Post-training performance on the SocialVille tasks were similar to initial performance of the healthy controls. Subjects also showed improvements on standard measures of social cognition, social functioning, and motivation. No improvements were recorded for emotion recognition indices on the MSCEIT, or on quality of life scales. Conclusion This study provides an initial proof of concept for online social cognition training in schizophrenia. This form of training demonstrated feasibility and resulted in within-subject gains in social functioning and motivation. This pilot study represents a first step towards validating this training approach; randomized controlled trials, now underway, are designed to confirm and extend these findings.

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The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia

Cited by 55 publications

References 54 publications

Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats

Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats

Facial emotion perception in schizophrenia: Does sex matter?

A novel, online social cognitive training program for young adults with schizophrenia: A pilot study

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