The influence of cold-torpor and water deprivation on plasma and kidney glycosaminoglycans in emydine turtles

Kupchella, Charles E.; Heckman, James R.; Lega, Robert D.; Plamp, C E

doi:10.1016/0300-9629(77)90189-x

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…NDST3 is a member of the heparan sulphate/heparin GlcNAc N-deacetylase/N-sulphotransferase family and increased expression indicates an increase in N-sulphation of heparin sulphate in the kidney. Since kidney glucosaminoglycans have been shown to be related to the ability of turtles to conserve water, 29 it can be speculated that the increased expression of NDST3 in hibernating black bear kidneys protect the animals during the long period of dehydration during winter sleep. Moreover, since the endothelial glycocalyx on the vascular endothelial cells plays a major role in albuminuria and kidney disease, 30 it could be speculated that upregulation of NDST3 may protect the endothelial glycocalyx in bear kidneys during the anuric hibernation.…”

Section: Discussionmentioning

confidence: 99%

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

et al. 2018

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The prevalence of chronic kidney disease (CKD) is rising worldwide and 10–15% of the global population currently suffers from CKD and its complications. Given the increasing prevalence of CKD there is an urgent need to find novel treatment options. The American black bear (Ursus americanus) copes with months of lowered kidney function and metabolism during hibernation without the devastating effects on metabolism and other consequences observed in humans. In a biomimetic approach to better understand kidney adaptations and physiology in hibernating black bears, we established a high-quality genome assembly. Subsequent RNA-Seq analysis of kidneys comparing gene expression profiles in black bears entering (late fall) and emerging (early spring) from hibernation identified 169 protein-coding genes that were differentially expressed. Of these, 101 genes were downregulated and 68 genes were upregulated after hibernation. Fold changes ranged from 1.8-fold downregulation (RTN4RL2) to 2.4-fold upregulation (CISH). Most notable was the upregulation of cytokine suppression genes (SOCS2, CISH, and SERPINC1) and the lack of increased expression of cytokines and genes involved in inflammation. The identification of these differences in gene expression in the black bear kidney may provide new insights in the prevention and treatment of CKD.

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Section: Discussionmentioning

confidence: 99%

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

et al. 2018

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“…NDST3 is a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family and increased expression indicates an increase of Nsulfation of heparin sulfate in the kidney. Since kidney glucosaminoglycans have been shown to be related to the ability of turtles to conserve water, 14 it can be speculated that the increased expression of NDST3 in hibernating black bear kidneys protect the animals during the long period of dehydration during winter sleep. Moreover, since the endothelial glycocalyx on the vascular endothelial cells plays a major role in albuminuria and kidney disease, 15 it could be speculated that upregulation of NDST3 may protect the endothelial glycocalyx in bear kidneys during the anuric hibernation.…”

Section: American Black Bear (Ursus Americanus)mentioning

confidence: 99%

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

Srivastiva

Sarsani

Fiddes

et al. 2018

Preprint

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The prevalence of chronic kidney disease (CKD) is rising worldwide and 10-15% of the global population currently suffers from CKD and its complications. Given the increasing prevalence of CKD there is an urgent need to find novel treatment options. The American black bear (Ursus americanus) copes with months of lowered kidney function and metabolism during hibernation without the devastating effects on metabolism and other consequences observed in humans. In a biomimetic approach to better understand kidney adaptations and physiology in hibernating black bears, we established a high-quality genome assembly. Subsequent RNA-Seq analysis of kidneys comparing gene expression profiles in black bears entering (late fall) and emerging (early spring) from hibernation identified 169 protein-coding genes that were differentially expressed. Of these, 101 genes were downregulated and 68 genes were upregulated after hibernation. Fold changes ranged from 1.8-fold downregulation (RTN4RL2) to 2.4-fold upregulation (CISH). Most notable was the upregulation of cytokine suppression genes (SOCS2, CISH, and SERPINC1) and the lack of increased expression of cytokines and genes involved in inflammation. The identification of these differences in gene expression in the black bear kidney may provide new insights in the prevention and treatment of CKD.All rights reserved. No reuse allowed without permission.was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

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The kidney of a teleost, Spinachia spinachia II. Histochemical identification of sialic acid-containing glycoprotein and fine structure of mucus secreting cells

Hentschel

1979

Tissue and Cell

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The influence of cold-torpor and water deprivation on plasma and kidney glycosaminoglycans in emydine turtles

Cited by 5 publications

References 16 publications

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

The kidney of a teleost, Spinachia spinachia II. Histochemical identification of sialic acid-containing glycoprotein and fine structure of mucus secreting cells

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