The influence of climate on the basal metabolic rate of small mammals: a slow-fast metabolic continuum

Lovegrove, Barry G.

doi:10.1007/s00360-002-0309-5

Cited by 306 publications

(274 citation statements)

References 206 publications

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“…Consistent with this view and the predictions of the Climatic Variability Hypothesis, MIBMR increases with latitude, which explained 20% and 15% of the variation in all mammals and rodents, respectively (Figure 2c,e). These results corroborate a previous analysis of a smaller dataset (267 species) of small (< 1 kg) mammals [122]. Other aspects of metabolic capacity, such as nonshivering thermogenesis in rodents, also increase with latitude and decrease with environmental temperature [123].…”

Section: Discussionsupporting

confidence: 89%

A Macrophysiological Analysis of Energetic Constraints on Geographic Range Size in Mammals

et al. 2013

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Physiological processes are essential for understanding the distribution and abundance of organisms, and recently, with widespread attention to climate change, physiology has been ushered back to the forefront of ecological thinking. We present a macrophysiological analysis of the energetics of geographic range size using combined data on body size, basal metabolic rate (BMR), phylogeny and range properties for 574 species of mammals. We propose three mechanisms by which interspecific variation in BMR should relate positively to geographic range size: (i) Thermal Plasticity Hypothesis, (ii) Activity Levels/Dispersal Hypothesis, and (iii) Energy Constraint Hypothesis. Although each mechanism predicts a positive correlation between BMR and range size, they can be further distinguished based on the shape of the relationship they predict. We found evidence for the predicted positive relationship in two dimensions of energetics: (i) the absolute, mass-dependent dimension (BMR) and (ii) the relative, mass-independent dimension (MIBMR). The shapes of both relationships were similar and most consistent with that expected from the Energy Constraint Hypothesis, which was proposed previously to explain the classic macroecological relationship between range size and body size in mammals and birds. The fact that this pattern holds in the MIBMR dimension indicates that species with supra-allometric metabolic rates require among the largest ranges, above and beyond the increasing energy demands that accrue as an allometric consequence of large body size. The relationship is most evident at high latitudes north of the Tropics, where large ranges and elevated MIBMR are most common. Our results suggest that species that are most vulnerable to extinction from range size reductions are both large-bodied and have elevated MIBMR, but also, that smaller species with elevated MIBMR are at heightened risk. We also provide insights into the global latitudinal trends in range size and MIBMR and more general issues of phylogenetic and geographic scale.

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Section: Discussionsupporting

confidence: 89%

A Macrophysiological Analysis of Energetic Constraints on Geographic Range Size in Mammals

et al. 2013

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“…Basal metabolic rates (7) co-vary with ODT. Antarctic residence, exposing humans to extreme cold, is associated with increased TSH response to TSH-releasing hormone and decreased thyroxin (FT4), which correlate with metabolic markers, such as total and LDL-cholesterol, of thyroid hormone activity in the liver and adipose tissue (22).…”

Section: Discussionmentioning

confidence: 99%

“…There is a 21°C difference between the average temperatures for the extreme months of July and February in the middle part of Sweden (). Basal metabolic rates co-vary with ODT (7), and heat treatment of rats increases skeletal muscle insulin sensitivity (8). Little is known of the effect of low ODT on human insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Seasonal variations of insulin sensitivity from a euglycemic insulin clamp in elderly men

Berglund¹,

Berne²,

Svärdsudd³

et al. 2011

Upsala Journal of Medical Sciences

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Introduction.Seasonal variations in hemoglobin-A1c have been reported in diabetic patients, but the underlying mechanisms have not been elucidated.Aims.To study if insulin sensitivity, insulin secretion, and fasting plasma glucose showed seasonal variations in a Swedish population-based cohort of elderly men.Methods.Altogether 1117 men were investigated with a euglycemic insulin clamp and measurements of fasting plasma glucose and insulin secretion after an oral glucose tolerance test. Values were analyzed in linear regression models with an indicator variable for winter/summer season and outdoor temperature as predictors.Results.During winter, insulin sensitivity (M/I, unit = 100 × mg × min-1 × kg-1/(mU × L-1)) was 11.0% lower (4.84 versus 5.44, P = 0.0003), incremental area under the insulin curve was 16.4% higher (1167 versus 1003 mU/L, P = 0.007). Fasting plasma glucose was, however, not statistically significantly different (5.80 versus 5.71 mmol/L, P = 0.28) compared to the summer season. There was an association between outdoor temperature and M/I (0.57 units increase (95% CI 0.29–0.82, P < 0.0001) per 10°C increase of outdoor temperature) independent of winter/summer season. Adjustment for life-style factors, type 2 diabetes, and medication did not alter these results.Conclusions.Insulin sensitivity showed seasonal variations with lower values during the winter and higher during the summer season. Inverse compensatory variations of insulin secretion resulted in only minor variations of fasting plasma glucose. Insulin sensitivity was associated with outdoor temperature. These phenomena should be further investigated in diabetic patients.

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“…Biologists are keenly interested in understanding why metabolic rates differ between ectotherms and endotherms, within various clades and within species (Bennett and Ruben 1979; Konarzewski and Diamond 1995; Lovegrove 2000, 2003; Rezende et al 2004; Anderson and Jetz 2005; Clarke and Portner 2010). Nonetheless, a full understanding of the mechanistic and evolutionary factors responsible for variation in metabolic rate remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate

Wone

Donovan

Cushman

et al. 2013

Comparative Biochemistry and Physiology Part A: Molecular &

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Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appear to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.

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The influence of climate on the basal metabolic rate of small mammals: a slow-fast metabolic continuum

Cited by 306 publications

References 206 publications

A Macrophysiological Analysis of Energetic Constraints on Geographic Range Size in Mammals

A Macrophysiological Analysis of Energetic Constraints on Geographic Range Size in Mammals

Seasonal variations of insulin sensitivity from a euglycemic insulin clamp in elderly men

Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate

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