“…In the first study of CRM involvement by Sagar et al [25], significantly (p < 0.01) more patients with a positive CRM (55%) developed a local recurrence as compared to those without involvement of the CRM (13%) [25]. These results were later proven by other studies, which also identified a prognostic role of a positive CRM on recurrences [3,13,14,17,18,22,26]. Chao et al [26] found a significant influence of an involved CRM not only on loco-regional but also on distant recurrences, while an involvement to the CRM of less than 1 mm was associated with early loco-regional recurrences.…”