The influence of cimetidine, a histamine H2-receptor antagonist, on the gastric effects of reserpine in rats

Lau, H. K.; Ogle, C. W.

doi:10.1016/0014-2999(81)90208-9

Cited by 22 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-treatment ofanimals with cimetidine or pentagastrin led to substantial differences in gastric acid secretion, comparable with those reported by other investigators (Lau and Ogle, 1981;Whitford and Pashley, 1984). Cimetidine inhibited gastric acid secretion by approximately 85%, and pentagastrin more than doubled acid secretion, relative to untreated controls.…”

Section: Discussionsupporting

confidence: 79%

Influence of Gastric Acidity on Fluoride Absorption in Rats

Messer

Ophaug

1993

J Dent Res

View full text Add to dashboard Cite

The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85) were pre-treated with cimetidine (to inhibit gastric acid secretion) or pentagastrin (to stimulate gastric acid secretion) or were untreated controls, and given 50 micrograms F by stomach intubation. The pH of the F-containing solution was varied in the cimetidine-pre-treated group (pH 1.5, 5.5, 8.5), and was 5.5 for the control and pentagastrin-pre-treated groups. Gastric emptying was measured by addition of 14C polyethylene glycol to the F solution as an unabsorbed marker of fluid movement. F absorption was measured after 10, 20, and 40 min. The rate of gastric emptying was unaffected by pre-treatment or pH of the intubating solution. Initially, F absorption was greatest at low pH. After 40 min, absorption was comparable in all groups, averaging approximately 70% of the initial dose. The extent of absorption from the stomach was inversely related to pH, but increased absorption from the small intestine compensated for the low gastric absorption at high pH.

show abstract

Section: Discussionsupporting

confidence: 79%

Influence of Gastric Acidity on Fluoride Absorption in Rats

Messer

Ophaug

1993

J Dent Res

View full text Add to dashboard Cite

show abstract

Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions

1986

View full text Add to dashboard Cite

The suitability of urethane anesthesia for physiopharmacological experiments in various systems is briefly reviewed. Urethane anesthesia appears to be suitable for various types of studies on respiratory function and on reflex activation of motility of the urinary bladder and some sections of the intestinal tract. However, urethane produces a variety of potentially disturbing side-effects at endocrine and renal level.

show abstract

Fluoride absorption: The influence of gastric acidity

1984

View full text Add to dashboard Cite

The influence of gastric acidity on the absorption of intragastrically administered fluoride was investigated in rats. Intact animals were pretreated with atropine or cimetidine to reduce gastric acid secretion or were given fluoride in NaHCO3 to reduce the acidity of the gastric contents. Compared with pentagastrin-treated animals or animals that received fluoride in 0.1 N HCl, their rate of fluoride absorption was markedly reduced as judged by lower plasma fluoride concentrations and areas under the time-plasma concentration curves, especially during the first hour after dosing. In crossover studies with the stomachs isolated in situ, fluoride absorption was at least 50% faster from a pH 2.1 buffer compared with its absorption from a pH 7.1 buffer. The findings are consistent with the hypothesis that fluoride is absorbed from the gastric lumen principally as the undissociated molecule, HF. The results may contribute to a more complete understanding of acute fluoride toxicity, the development of dental fluorosis and, perhaps, the use of fluoride in the treatment of osteoporosis.

show abstract

The influence of cimetidine, a histamine H2-receptor antagonist, on the gastric effects of reserpine in rats

Cited by 22 publications

References 29 publications

Influence of Gastric Acidity on Fluoride Absorption in Rats

Influence of Gastric Acidity on Fluoride Absorption in Rats

Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions

Fluoride absorption: The influence of gastric acidity

Contact Info

Product

Resources

About