The influence of cervical sympathetic neurons on parathyroid hormone and calcitonin release in the rat: Independence of pineal mediation

Stern, Javier E.; Esquifino, Ana I.; Bonacho, Manuel García; Cardinali, Daniel P.

doi:10.1111/j.1600-079x.1997.tb00296.x

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Superior cervical ganglionectomy resulted in the functional abnormalities of these tissues, which include such disparate effects as the alteration of prolactin release [12], disruption of the photoperiodic control of reproduction [13], and of thyroid and parathyroid functions [14,15]. In the present experiments, superior cervical ganglionectomy augmented the increasing effects of i.c.v.…”

Section: Discussionmentioning

confidence: 59%

Interleukin-1β-Induced Increases of Plasma Catecholamine Levels in Rats: Enhancement by Superior Cervical Ganglionectomy

Wang¹,

Murakami²,

Okada³

et al. 2002

Pharmacology

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In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1β (IL-1β)-induced elevation of plasma catecholamines. In sham-operated rats, intracerebroventricularly (i.c.v.) administered IL-1β (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline. In superior cervical ganglionectomized rats, however, IL-1β significantly elevated adrenaline to a greater extent than noradrenaline, and they were attenuated by i.c.v. administration of melatonin (100 ng/animal). Superior cervical ganglionectomy effectively reduced the plasma level of melatonin and urinary excretion of 6-sulfatoxymelatonin (a main urinary melatonin metabolite). These results suggest that superior cervical ganglia inhibit central sympatho-adrenomedullary outflow (especially adrenomedullary outflow) by increasing melatonin synthesis in the pineal gland of rats.

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Section: Discussionmentioning

confidence: 59%

Interleukin-1β-Induced Increases of Plasma Catecholamine Levels in Rats: Enhancement by Superior Cervical Ganglionectomy

Wang¹,

Murakami²,

Okada³

et al. 2002

Pharmacology

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“…In hemodialysis patients with hyperparathyroidism, parathyroidectomy significantly increases nocturnal melatonin secretion [17]. Participation of the pineal gland in the modulation of the parathyroid hormone (PTH) and calcitonin release in rats after changes in the activity of the cervical sympathetic nerves is studied [18]. In scientific publications there are no works on a comprehensive study of the of the epiphyseal -parathyroid axis structural components in sexually mature male rats under the conditions of readaptation after long-term exposure to the complex of heavy metal salts.…”

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confidence: 99%

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Hryntsova¹,

Tymakova²,

Romaniuk³

2020

PEP

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An important environmental problem is the pollution of the environment with heavy metal salts, which are in various combinations depending on the region and cause adverse effects on public health. The endocrine system together with the immune and nervous system maintains homeostasis in the body. In order to study the morphofunctional rearrangements of the epiphyseal-parathyroid axis structural components in rats during 30 days of readaptation after 90 days of exposure to heavy metal salts (zinc (ZnSO4 · 7H2O) — 5 mg/l, copper (CuSO4 · 5H2O) — 1 mg/l, iron (FeSO4 ) — 10 mg/l, manganese (MnSO4 · 5H2O) — 0.1 mg/l, lead (Pb(NO3 ) 2 ) — 0.1 mg/l and chromium K2Cr2O7) — 0.1 mg/l) an experiment was performed on 24 white sexually mature male rats weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed ordinary drinking water for 30 days. Morphological, statistical, immunohistochemical and biochemical research methods were used. The 30-day period of readaptation after 90 days of heavy metal salts intake is insufficient to completely restore homeostasis in the epiphyseal-parathyroid system, which is at the stage of chronic stress «subcompensation». Significant morphological changes on the part of the vascular bed of the pineal gland and parathyroid glands (blood stasis, erythrocyte aggregation, sludge phenomenon) were determined, an active glial reaction was formed in the pineal gland, and the structure of the epithelial trabeculae of the glands was disturbed. The levels of parathyroid hormone and calcium in the blood of experimental animals were significantly lower than those of experimental animals. There is a greater vulnerability and faster dynamics of the regenerative processes in the parathyroid glands to the action of salts of heavy metals in comparison with the pineal gland. The development of hypofunction of the parathyroid glands, of course, has a negative effect on the overall calcium metabolism in the body, the development of compensatory and adaptive processes and the course of the general adaptation syndrome in response to the damaging agent.

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