The influence of cardiac cholinergic activation on the induction and maintenace of ventricular fibrillation

Abstract

The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which have a high sympathetic autoregulation and in 3/6 cats only, 20-40 secs after the latter had been given adrenaline. ACh (10-45 micrograms/kg) and methacholine (10-40 micrograms/kg) also significantly prolonged the fibrillatory period induced electrically in cats and rats with and without atrial or ventricular pacing. The induction or prolongation of VF did not occur when higher doses of ACh (50-100 micrograms/kg) were given to rats. The influence of moderate amounts of cholinergic agents on the heart may be due to localised effects resulting in asynchronous activity. Alternatively, they may produce a discharge of multiple ectopic pacemakers or a disturbance in impulse conduction. Higher doses of ACh depress the S-A and ventricular ectopic activity node thereby decreasing the probability of inducing VF. It is concluded that under conditions of raised cardiac adrenergic activity, a moderate increase in cholinergic influence can both induce and prolong VF. The relevance of these findings to the "sudden infant death" syndrome is discussed.

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

“…It is interesting to note that most of the 12 AEs used to build the anticholinesterase safety profile can be explained by pharmacological activity. Indeed, cholinergic activation might enhance aggressive behaviour, 20 agitation, 21 anal incontinence, 22 cholinergic syndrome, 21 decreased appetite, 23 sudden death 24 and urinary incontinence 25 . The cholinergic pathway may also play a role in the onset of a confusional state, delirium, hallucinations, paranoia and vomiting 26,27 …”

The effect of heart rate on the termination of electrically induced ventricular fibrillation in the isolated perfused rat heart

“…It has been suggested by Manoach and his colleges (1,17) that increased adrenergic activity is associated with a tendency towards TVF, as opposed to the cholinergic effect which tends to predispose to SVF.…”