The influence of breed on the susceptibility of sheep and goats to a single experimental infection with Haemonchus contortus

Preston, JM; Ew, Allonby

doi:10.1136/vr.103.23.509

Cited by 84 publications

(29 citation statements)

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“…Many approaches to determine host gastrointestinal parasite resistance in small ruminants have been explored (Hoste & Torres-Acosta, 2011;Knox, Torres-Acosta, & Aguilar-Caballero, 2006;Preston & Allonby, 1978;Vlassoff, Bisset, & McMurtry, 1999;Woolaston & Baker, 1996). In this study, more than 200 (Spanish and Myotonic) goats on Virginia State University Randolph farm, that were naturally exposed to Haemonchus contortus were screened and goats simultaneously exhibiting an anthelmintic treatable FEC (>2000) and a normal PCV (>18) were placed in the resistant (>2000 FEC and > 18 PCV) category.…”

Section: Resultsmentioning

confidence: 99%

Interleukin 13 as a Biomarker for Parasite Resistance in Goats Naturally Exposed to Haemonchus contortus

Corley¹,

Jarmon²

2012

JAS

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Gut expulsion of some mammalian nematodes requires IL-13 secreted by Th2 cells. Interleukin 13 enhances gut contractions and glycoprotein hyper-secretion that propel parasites to detach from the gut wall. Haemonchus contortus is a gastrointestinal blood sucking nematode of small ruminants. This study evaluated expression of IL-13 in selected parasite resistant Spanish and Myotonic goats. Whole blood, and abomasal and intestinal tissues were harvested from goats exhibiting susceptibility and resistance to Haemonchus contortus through standard and molecular detection methods. An indirect Enzyme Linked Immunosorbent Assay was performed to determine IL-13 expression. Results showed that IL-13 was expressed 70% more in intestinal than abomasal tissues. Parasite resistant goats expressed more IL-13 than susceptible goats. These data indicate that IL-13 expression may be useful as a biomarker for resistance to Haemonchus contortus infection in goats, allowing IL-13 based anthelmintic drug development and goat producers the ability to select parasite resistant animals.

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Section: Resultsmentioning

confidence: 99%

Interleukin 13 as a Biomarker for Parasite Resistance in Goats Naturally Exposed to Haemonchus contortus

Corley¹,

Jarmon²

2012

JAS

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“…Another limitation of this parameter is that in mixed infection, several trichostrongyle species are involved and eggs of these species cannot be distinguished morphologically. They also differ in fecundity, seasonality, Evaluation of resistance status of small ruminants Preston and Allonby, 1978;Barger, 1984;Zajac et al, 1988;Douch et al, 1995;Mugambi et al, 1996;Wanyangu et al, 1997;Miller et al, 1998;Haile et al, 2002;Matika et al, 2003;Vanimisetti et al, 2004;Amarante et al, 2005;Miller et al, 2006;Burke and Miller, 2008;Kemper et al, 2009 andHurtado et al, 2010;Saddiqi et al, 2010a and2010b. Packed cell volume Hoffman, 1981;Barger, 1984;Zajac et al, 1990;Gray et al, 1992;Mugambi et al, 1996 and2005;Wanyangu et al, 1997;Miller et al, 1998 andAmarante et al, 1999a;Notter et al, 2003;Bricarello et al, 2004 andGonzalez et al, 2008;Chiejina et al, 2010;Saddiqi et al, 2010a and2010b.…”

Section: Fecmentioning

confidence: 99%

Markers/parameters for the evaluation of natural resistance status of small ruminants against gastrointestinal nematodes

Saddiqi¹,

Sarwar

Iqbal

et al. 2012

Animal

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The high prevalence of anthelmintic-resistant gastrointestinal nematodes (GINs) throughout the world has led to the need for alternative worm control strategies. One of the possible substitutes to reduce the problems of drug resistance and residue is the evaluation/breeding of small ruminants for greater resistance to the GINs (organically produced), which in turn would be a helpful tool to predict the performance of an animal. At present, the existing diversity in the genetic potential to resist/tolerate GINs infection both within and between breeds has been validated. Successful selection of animals to define the genotype and identified resistance is related to the employed markers. A number of phenotypic traits such as faecal egg count (FEC), worm burden, serum antibodies, peripheral eosinophilia, packed cell volume, live weight, serum protein and albumin concentrations have been used for this purpose both in natural and artificial infections. Relatively resistant/tolerant animals have also been found to have mastocytosis, globule leucocytes, high levels of histamine and immunoglobulin (Ig) A and IgE concentrations. Of these traits, the principal and most practical measurement used to assess resistance status in animals undergoing similar parasite challenges is FEC. FEC has a positive/negative correlation with other biochemical, cellular and immunological parameters; however, the reliability of individual trial is often questioned and valuable information regarding the genetic makeup can be obtained from pooled data of a large number of trials and parameters. This paper covers all the aspects reported in the literature on various parameters considered to evaluate the resistance status of a range of small ruminant breeds.

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“…al., 2015) in D.G Khan, Pakistan, 58% in Bangladesh (Nuruzzaman et al, 2012), 44% in Iran (Garedaghi and Bahavarnia, 2013), 60% in Eastern Ethiopia (Sissay et al, 2007) and 77.7% in Multan (Tasawar et al, 2010). The differences in prevalence reported by these studies could be accounted on the basis of differential management practices (Lindqvist et al, 2001;Barger 1999;Mandonnet et al, 2003), natural resistance (Pal and Qayyum, 1992;Soulsby 2005), drug treatment (Ali et al, 1997;Barnes et al, 2001), and local geo-climatic factors (Gupta et al, 1987;Pal and Qayyum, 1993;Chaudhary et al, 2007) and nutrition (Preston and Allonby, 1987;Data et al, 1999). Eggs of Haemonchus contortus in sample observed under 100X microscope is shown in Fig.…”

Section: Overall Prevalencementioning

confidence: 99%

Prevalence of Haemonchus contortus in Goats of Western Chitwan of Nepal

Adhikari

Rana

Kaphle

et al. 2017

Int J Appl Sci Biotechnol

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The research was done in cross sectional design to study about the prevalence of Haemonchus contortus in goats of Western Chitwan of Nepal. A total of 252 fecal samples were collected through purposive sampling. Fecal samples were examined through sedimentation and floatation method. Egg per gram (EPG) was calculated through Mac Master Counting Technique of positive samples. Total prevalence was found to be 13.89%. Infection of parasite was more prevalent in males (15.18%) than in female (12.86%) but was statistically non-significant (P>0.05). In non-dewormed goats (40.32%), the prevalence was significantly (P<0.05) higher than in dewormed goats (5.26%). The results regarding the relationship between different age groups of goats and H. contortus showed that highest prevalence (14.54%) of parasite was observed in age group of below 1 year and the lowest (12.96%) in age group of above 2 year, statistically non-significant (P>0.05). Maximum goats were found with medium level of infestation through EPG. This study shows higher prevalence of Haemonchus in non-dewormed than in dewormed goats which is statistically significant at (P<0.05). Thus, effective deworming programme and management must be maintained in order to upgrade the health status and maximize the benefits from the animal.

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The influence of breed on the susceptibility of sheep and goats to a single experimental infection with Haemonchus contortus

Cited by 84 publications

References 0 publications

Interleukin 13 as a Biomarker for Parasite Resistance in Goats Naturally Exposed to Haemonchus contortus

Interleukin 13 as a Biomarker for Parasite Resistance in Goats Naturally Exposed to Haemonchus contortus

Markers/parameters for the evaluation of natural resistance status of small ruminants against gastrointestinal nematodes

Prevalence of Haemonchus contortus in Goats of Western Chitwan of Nepal

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