The influence of bone morphology on fracture toughness of the human femur and tibia

Yeni, Yener N.; Brown, Christopher U.; Wang, Z.; Norman, Timothy L.

doi:10.1016/s8756-3282(97)00173-7

Cited by 312 publications

(236 citation statements)

References 31 publications

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…Bovine secondary bone and human secondary bone have been shown to be similar in density and morphological appearance [9]. More significantly, the bovine bone specimens used in this study contained osteons in the range (12.8 k 5.5 osteons/mm2) that is directly comparable to the range reported in literature for human bone (8-26 osteons/mm2; [42]; 1 1.4-1 5.4 osteons/mm2; [15]). The mechanical properties between the two species under monotonic and fatigue loading are also comparable [11,30].…”

Section: Resultssupporting

confidence: 66%

Damage mechanisms and failure modes of cortical bone under components of physiological loading

George

Vashishth

2005

Journal Orthopaedic Research

View full text Add to dashboard Cite

Fatigue damage development in cortical bone was investigated in vitro under different mechanical components of physiological loading including tension, compression, and torsion. During each test, stress and strain data were collected continuously to monitor and statistically determine the occurrence of the primary, secondary, and tertiary stages associated with fatigue and/or creep failure of bone. The resultant microdamage and failure modes were identified by histological and fractographic analysis, respectively. The tensile group demonstrated Mode I cracking and the three classic stages of fatigue and creep suggesting a low crack initiation threshold, steady crack propagation and final failure by coalescence of microcracks. In contrast, the compressive group displayed Mode I1 cracking and a two-stage fatigue behavior with limited creep suggesting a high crack initiation threshold followed by a sudden fracture. The torsion group also displayed a two-stage fatigue profile but demonstrated extensive damage from mixed mode (Modes I1 and 111) microcracking and predominant time-dependant damage. Thus, fatigue behavior of bone was found to be uniquely related to the individual mechanical components of physiological loading and the latter determined the specific damage mechanisms associated with fatigue fracture.

show abstract

Section: Resultssupporting

confidence: 66%

Damage mechanisms and failure modes of cortical bone under components of physiological loading

George

Vashishth

2005

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Toughness is the property of a composite material that reflects its resistance to crack propagation after it is stressed beyond its elastic limit. Yeni et al (1997) showed that toughness of the femoral shaft in tension was dependent strongly and positively on osteon density as well as on porosity and age. Toughness in shear was positively dependent on osteon density and age but not independently on porosity.…”

Section: Discussionmentioning

confidence: 99%

Super‐osteons (remodeling clusters) in the cortex of the femoral shaft: Influence of age and gender

et al. 2001

View full text Add to dashboard Cite

Previous studies of cortical remodeling in the fractured femoral neck indicated that the merging of spatially clustered remodeling osteons could result in the formation of deleteriously large cavities associated with femoral neck fracture. This study aimed to identify whether remodeling osteons in the femoral shaft were also clustered and to assess the influence of age and gender. Microradiographic images of femoral mid-shaft cross-sections from 66 subjects over 21 years of age were analyzed to determine the number, size and location of all Haversian canals. Those most recently remodeled were identified using an edge-detection algorithm highlighting the most marked differential gradients in grey levels. Cluster analysis (JMP software) of these osteons identified the proportion of recently remodeled osteons that were within 0.75mm clusters. As in the femoral neck, remodeling osteons were significantly more clustered than could occur by chance (real, 59.4%; random, 39.4%; P Ͻ 0.0001). The density of these clusters (number/mm 2 ) was not significantly associated with subject age or gender but was greatest near the periosteum and decreased toward the marrow cavity (periosteal 0.043 Ϯ 0.004; mid-cortex 0.028 Ϯ 0.003; endosteal 0.017 Ϯ 0.002). Cortical porosity increased with age. The presence of giant canals (diameter Ͼ385 m) was inversely related to the presence of clusters (R 2 ϭ 0.237, P Ͻ 0.0001). This data suggest that remodeling osteons tend to be spatially colocalized in the shaft as they are in the neck of the femur and their presence is independent of age or gender. We propose that these remodeling clusters be termed super-osteons. The negative relationship between super-osteons and giant canals raises the intriguing possibility that loss of the control of remodeling depth results in the merging of osteonal systems to form deleteriously large cortical cavities with a marked reduction in bone strength. Anat Rec 264: 378 -386, 2001.

show abstract

“…The quantities measured from each field included the total area of the selected field, total area of osteons including the Haversian canals, total area of Haversian and Volkmann's canals, and resorption spaces (defined as porosity), and the total number of osteons. Following Yeni et al, 2 the osteon fragments that merged with an adjacent osteon but had a distinct Haversian canal and a clear cement line were included in the quantification of the osteonal area and number of osteons.…”

Section: Quantification Of Microstructural Parametersmentioning

confidence: 99%

“…1,2 The changes in geometrical properties of bone influence the amount of loading the bone can carry. In addition to the changes in the actual area, the spatial distribution of bone is important in determining mechanical response.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6] In particular, it has been shown that, similar to cross-sectional parameters, [7][8][9][10][11][12][13][14] microstructural parameters exhibit age-related changes and affect the propensity of bone to fracture. 2 These observations suggest that age-related changes in geometrical and microstructural properties may interact with each other and have a combined effect on bone fractures, however, the level of interaction is unknown.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interactions between microstructural and geometrical adaptation in human cortical bone

Ural

Vashishth

2006

J. Orthop. Res.

View full text Add to dashboard Cite

With aging and in disease, the changes in bone microstructure and geometry influence the mechanical properties of cortical bone, however, the level of interaction between the two is not known. Here, we investigate the interaction between the changes in microstructural and geometrical properties of the aging male tibia in proximal and distal middiaphysis. The microstructural measurements include variables related to the size and density of osteons and intracortical porosity. The macroscopic geometrical properties include variables related to bone surfaces (periosteal and endosteal) and cross section (area, moment of inertia). Site-specific correlations were found between the microstructural and geometrical properties along the bone length and at different bone surfaces. In contrast to the proximal middiaphysis of male tibia, where no correlation existed, significant (p < 0.05) correlations were found in the distal middiaphysis of tibia. The changes in parameters partially related to bone formation in the cortex, including the osteonal area, showed positive correlations with an increase in the periosteal diameter. Similarly, parameters related to bone resorption and/or failed formation in the cortex, including porosity and pore size, showed significant correlations with cortical thinning. These findings support the concept that, with aging, anabolic and catabolic responses in the human tibia at microstructural and macrostructural levels are spatially related and site specific. ß

show abstract

The influence of bone morphology on fracture toughness of the human femur and tibia

Cited by 312 publications

References 31 publications

Damage mechanisms and failure modes of cortical bone under components of physiological loading

Damage mechanisms and failure modes of cortical bone under components of physiological loading

Super‐osteons (remodeling clusters) in the cortex of the femoral shaft: Influence of age and gender

Interactions between microstructural and geometrical adaptation in human cortical bone

Contact Info

Product

Resources

About