The Influence of Bone Cement Implantation in Primary Hip Arthroplasty on S100B Protein Serum Concentration and Patients’ Cognitive Functions as Markers of Brain Damage

Tomaszewski, Dariusz; Rybicki, Zbigniew; Możański, Marcin

doi:10.1007/s00068-009-8084-6

Cited by 3 publications

(2 citation statements)

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“…Elevated serum S100B protein levels may be due to the release of S100B protein from bone marrow, as well as the transfer of cellular materials from the site of the surgery through the bloodstream into the brain. Because all patients with intraoperative mean blood pressure dropping below 50 mmHg were excluded from the study, hypotension was eliminated as a possible cause of the elevation of S100B concentration [ 18 ].…”

Section: Biomarkers Of Brain Damage In Orthopedic Patientsmentioning

confidence: 99%

Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update

Tomaszewski

2015

BioMed Research International

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The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients varies from 16% to 45%, although it can be as high as 72%. As a consequence, the hospitalization time of patients who developed POCD was longer, the outcome and quality of life were worsened, and prolonged medical and social assistance were necessary. In this review the short description of such biomarkers of brain damage as the S100B protein, NSE, GFAP, Tau protein, metalloproteinases, ubiquitin C terminal hydrolase, microtubule-associated protein, myelin basic protein, α-II spectrin breakdown products, and microRNA was made. The role of thromboembolic material in the development of cognitive decline was also discussed. Special attention was paid to optimization of surgical and anesthetic procedures in the prevention of postoperative cognitive decline.

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Section: Biomarkers Of Brain Damage In Orthopedic Patientsmentioning

confidence: 99%

Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update

Tomaszewski

2015

BioMed Research International

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“…This explanation may be supported by the increased serum concentration of the S100B protein, a biochemical marker of brain damage. An increased concentration of S100B protein was noted in patients after orthopedic surgery, including big joint arthroplasty [7,14]. However, Soh et al [16] suggest that the degree and duration of the decrease in perioperative rSO2 values were not associated with delirium in elderly patients after spinal surgery.…”

Section: Discussionmentioning

confidence: 99%

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2023

PJAMBP

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Continuous perioperative monitoring of blood oxygen saturation via pulse oximetry is an established standard of care. The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients is higher when compared to any other group of hospitalized patients. Although its etiology remains unclear, factors such as thromboembolic complications may play a role. Thromboembolic material, including that released from the surgery site, enters the bloodstream and then travels to the brain. The decrease in blood fl ow in the involved cerebral vessels may decrease cerebral oxygen saturation. Considering this, we decided to determine if the regional cerebral saturation monitored by near-infrared spectroscopy corresponds with readings of blood oxygen saturation monitored by pulse oximetry in patients who underwent primary total hip arthroplasty.A total of 20 patients scheduled for elective total hip arthroplasty were enrolled in the study. All orthopedic procedures were performed under spinal anesthesia and intravenous sedation. Monitoring of regional cerebral oxygen saturation (rSO2) was carried out from the time of the initiation of spinal anesthesia until the end of the surgery, using the near-infrared spectroscopy method. In all, 15 patients were analyzed. Background and

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Regional Cerebral Oxygen Saturation Decreases During Primary Hip Arthroplasty: An Analysis of Perioperative Regional Cerebral Oxygenation (rSO2), S100 Calcium-Binding Protein B (S100B) and Glial Fibrillary Acidic Protein (GFAP) Values. A Pilot Study

2019

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BackgroundThe incidence of postoperative cognitive dysfunction (POCD) after major joint arthroplasty is high. In the etiology of POCD, many factors have been cited, including thromboembolic complications. The incidence of cerebral embolization after lower extremity arthroplasty may be as high as 40–60%. The potential events of cerebral embolization could lead to a decrease in the regional cerebral oxygenation (rSO2) and increased serum levels of biochemical markers of brain damage. The objective of the study was to test whether there are any changes in the rSO2 values and serum markers of brain damage in patients who underwent total hip arthroplasty.Material/MethodsFifteen patients who underwent primary hip arthroplasty under spinal anesthesia were analyzed. The rSO2 was monitored using infrared spectroscopy. Biochemical analyses of S100 calcium-binding protein B (S100B) protein and fibrillary acidic protein (GFAP) serum concentrations were performed using immunoassay methods.ResultsThe values of rSO2 decreased during the surgery, but this was not related to mean arterial pressure variations or hemoglobin saturation. The concentration of S100B was increased compared to its preoperative values, and there were no changes in GFAP values. The changes in rSO2 readings correlated with the biomarkers’ levels just after the surgery.ConclusionsOur results suggest that S100B may be a more specific marker of astroglial damage in patients after primary total hip arthroplasty. The decrease in rSO2 readings may be due to micro-thromboembolic events that occurred during the surgery. However, the results of this study are preliminary, and further studies are needed to establish its clinical efficacy.

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The Influence of Bone Cement Implantation in Primary Hip Arthroplasty on S100B Protein Serum Concentration and Patients’ Cognitive Functions as Markers of Brain Damage

Abstract: There was a relationship between bone cement implantation during primary hip arthroplasty and elevated S100B protein plasma concentration during the short postoperative period, but the results of the neuropsychological tests did not reflect this.

Cited by 3 publications

References 24 publications

Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update

Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update

Untitled

Regional Cerebral Oxygen Saturation Decreases During Primary Hip Arthroplasty: An Analysis of Perioperative Regional Cerebral Oxygenation (rSO2), S100 Calcium-Binding Protein B (S100B) and Glial Fibrillary Acidic Protein (GFAP) Values. A Pilot Study

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