The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations

Salgueiro, Andréia Caroline Fernandes; Leal, Carina; Bianchini, Matheus Chimelo; Prado, Ianeli Oliveira do; Mendez, Andreas Sebastian Loureiro; Puntel, Robson Luiz; Folmer, Vanderlei; Soares, Félix Alexandre Antunes; Ávila, Daiana Silva; Puntel, Gustavo Orione

doi:10.1016/j.jep.2013.03.070

Cited by 44 publications

(40 citation statements)

References 23 publications

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“…Likewise, the increase in NPSH content in erythrocytes treated with AE of this plant needs to be further addressed. Importantly, with respect to increase in NPSH content, it was previously found that erythrocytes exposed to Bauhinia forficata and to Ilex paraguariensis aqueous extracts, under in vitro conditions, were found to have an increase in NPSH content (Salgueiro et al 2013, Portela et al 2017, which is similar to results present here.…”

supporting

confidence: 91%

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

Bianchini

Galvão

Tamborena

et al. 2017

An. Acad. Bras. Ciênc.

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Mentha pulegium (Lamiaceae) tea has been used as a traditional medicine; however, the modulatory effect of M. pulegium extracts on damage to human erythrocytes associated to t-butyl hydroperoxide (t-BHP) exposure remains to be investigated. Accordingly, we perform this study in order to test the hypothesis that aqueous and ethanolic extracts of M. pulegium could modulate the hemolysis associated to t-BHP exposure, non-protein thiol (NPSH) oxidation and lipid peroxidation (measured as thiobarbituric acid reactive substances -TBARS) in human erythrocytes. Samples were co-incubated with t-BHP (4 mmol/L) and/or aqueous or ethanolic extracts (10-1000 mg/mL) during 120 min to further analysis. We found that both extracts, when associated to t-BHP, potentiate NPSH oxidation and hemolysis. Moreover, both extracts significantly prevents against t-BHP-induced TBARS production. A significant correlation among hemolysis and NPSH levels was found. Taking together, our data points that the association of M. pulegium extracts with t-BHP culminates in toxic effect to exposed erythrocytes, besides its protective effect against t-BHP-induced TBARS production. So, we infer that the use of this extract may exert negative effect during painful crisis in sickle cell anemia. However, more studies are still necessary to better investigate/ understand the mechanism(s) involved in the toxic effect resultant from this association.

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supporting

confidence: 91%

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

Bianchini

Galvão

Tamborena

et al. 2017

An. Acad. Bras. Ciênc.

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“…This is relevant because iron plays a central role generating free radicals. In fact, plant extracts can chelate Fe 2+ and reduce its availability for interacting with H 2 O 2 , which decreases the hydroxyl radical formation via the Fenton reaction (27).…”

Section: Discussionmentioning

confidence: 99%

<em>Ilex paraguariensis</em> Extracts Extend the Lifespan of <em>Drosophila melanogaster </em>Fed a High Fat Diet

Colpo¹,

Lima²,

Rosa³

et al. 2017

Preprint

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Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effects on suppressing fat accumulation. Here, we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster given a high cholesterol diet. LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all of the examined extracts. In Drosophila, under extract treatment conditions, the mean lifespan was significantly extended from 38 to 43 days, there was an increase in the ability to support induced stress and decrease in lipid peroxidation products. Moreover, yerba mate extracts recovered the glutathione S-transferases (GST) activity and reduced the cholesterol level. Taken together, our results support that extracts can extend lifespan by reducing the detrimental effect of a high-fat diet in D. melanogaster, and this outcome can be associated with the compound content in the extracts. This study improves the understanding of natural interventions that reduce stress-induced oxidative damage, which is fundamental in promoting healthy ageing.

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“…1), indicating the potential use of these plant extracts as scavengers 9 . Moreover, it was found that the plant extracts significantly inhibited deoxyribose degradation (Fig.…”

Section: ) ----------------------------------------------------------mentioning

confidence: 99%

“…In this context, studies have focused on the potential use of natural compounds in a variety of conditions associated with OS, with special emphasis on medicinal herbs (and/or the metabolites) that are traditionally used by population [5][6][7][8] . Indeed, it has been reported that the consumption of medicinal plant extracts may exert positive effects in a variety of in vitro and in vivo models of human disorders 5,9 . Accordingly, the diet supplies antioxidants that act by augmenting cellular defenses protecting the cell against damage caused by ROS 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of some Medicinal Plant Extracts: Implications for Neuroprotection

Puntel¹,

Tamborena²,

Gularte³

et al. 2015

Pharmacologia

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Background and Objective:This study was conducted in order to evaluate the effect of aqueous and ethanolic extracts of Phyllanthus niruri, Uncaria tomentosa and Mentha pulegium against Lipid Peroxidation (LP). Additionally, it was determined the ability of these plants to scavenge specific free radicals and the interaction with iron ions. Methodology: The LP, scavenging activity, total phenolics and flavonoids were determined by colorimetric methods, whereas HPLC analysis was used to characterize the phytoconstituents. Results: Extracts significantly prevented both basal or induced (by Fe 2+ , malonate, sodium nitroprusside or ferrocyanide) LP. Accordingly, the extracts were better antioxidants at higher used concentrations, the effect of aqueous seems to be higher than ethanolic; the effect of plants were found to be P. niruri>M. pulegium>U. tomentosa; extracts were better antioxidants when used in rat brain homogenates, as compared to yolk phospholipids. Extracts also presented significant scavenging activity, prevented deoxyribose degradation and chelate Fe 2+. The HPLC analysis revealed that the extracts have different types and quantities of phytoconstituents. Conclusion: Altogether, presented results support the idea that antioxidant activities of extracts are related to the ability to scavenge specific free radicals and/or interaction with redox chemistry of iron ions. Thus, the broad range of antioxidant activity of these plants indicates the use with potential application to reduce LP associated to neurodegenerative disorders.

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The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations

Cited by 44 publications

References 23 publications

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

<em>Ilex paraguariensis</em> Extracts Extend the Lifespan of <em>Drosophila melanogaster </em>Fed a High Fat Diet

Antioxidant Activity of some Medicinal Plant Extracts: Implications for Neuroprotection

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