The influence of atopy on sICAM-1 serum levels in patients with allergic rhinitis and bronchial asthma

Abstract

Nastavak na pole|ini korica (continued on back cover)

Nasal Eosinophilia and Serum Soluble Intercellular Adhesion Molecule 1 in Patients with Allergic Rhinitis Treated with Montelukast Alone or in Combination with Desloratadine or Levocetirizine

“…5,6 In serum, sICAM-1 circulates as a biologically active molecule 5 and it seems that it modulates inflammation by binding to the integrins expressed on leukocytes. 7 Serum levels of sICAM-1 were higher in patients with asthma 8 and AR [8][9][10] than in healthy subjects [9][10][11] and in AR patients correlated with levels of ICAM-1 in nasal secretions. 12 The levels of serum sICAM-1 tend to increase during natural pollen exposure, 11,13 whereas in AR patients it is decreased significantly in the course of immunotherapy.…”