The Influence of Anxiety and Depression on Outcomes of Patients With Coronary Artery Disease

Januzzi, James L.; Stern, Theodore A.; Pasternak, Richard C.; DeSanctis, Roman W.

doi:10.1001/archinte.160.13.1913

Cited by 268 publications

(163 citation statements)

References 128 publications

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“…4 These values are higher than those in patients with other cardiac diseases, 29,30 so anxiety is also common in patients with HF.…”

Section: Depression Anxiety and Social Support In Hf Patientsmentioning

confidence: 91%

“…onsiderable evidence suggests a link between depression and the prognosis of patients with coronary heart disease, [1][2][3][4][5][6][7] and recently, the role of depression in patients with chronic heart failure (HF) has become the focus of many studies. [8][9][10][11][12][13][14] However, the impact of depression on prognosis has been less consistent in this disease state.…”

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confidence: 99%

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Anxiety and Poor Social Support are Independently Associated With Adverse Outcomes in Patients With Mild Heart Failure

Tsuchihashi-Makaya

Kato

Chishaki

et al. 2009

Circ J

102

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Background The impact of psychosocial states, such as depression or anxiety, and social support on the outcomes of stable outpatients with mild heart failure (HF) has not been evaluated in the "real world" clinical practice. Methods and ResultsIn the present study, 139 patients with a prior history of admission for HF provided the baseline demographic, clinical, socio-environmental, and psychosocial information. Cardiac death or re-admission because of worsening of HF was monitored during the follow-up period of 1 year. The prevalence of depression and anxiety were 37% and 37%, respectively, in HF patients. Depression was independently associated with male (sβ=-0.36, P=0.01), social ties (sβ=0.22, P=0.04) and low social support (sβ=-0.39, P<0.01). Anxiety was associated with alcohol drinking (sβ=0.22, P=0.04), brain natriuretic peptide ≥200 pg/dl (sβ=0.35, P<0.01), and low social support (sβ=-0.28, P=0.01). Kaplan-Meier analysis demonstrated that patients with anxiety (log-lank test; P<0.01) and lower scores of social support (P<0.01) had a higher rate of HF-related re-admission. Conclusions Anxiety and low social support were independently associated with HF-related re-admission, which indicates the need for their inclusion in the assessment and management of HF. (Circ J 2009; 73: 280 -287)

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“…4 These values are higher than those in patients with other cardiac diseases, 29,30 so anxiety is also common in patients with HF.…”

Section: Depression Anxiety and Social Support In Hf Patientsmentioning

confidence: 91%

mentioning

confidence: 99%

Anxiety and Poor Social Support are Independently Associated With Adverse Outcomes in Patients With Mild Heart Failure

Tsuchihashi-Makaya

Kato

Chishaki

et al. 2009

Circ J

102

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“…This factor signals hypothalamic neurons to synthesize and release corticotropin and also signals cells in the anterior part of the pituitary gland to release corticotropin. 59 Corticotropin stimulates release of cortisol and aldosterone from the adrenal cortex. 60 Hypercortisolemia contributes to abdominal obesity, 61 hypertension, 62 insulin resistance, 63 and inflammation.…”

Section: Activation Of the Hpa Axismentioning

confidence: 99%

Pathophysiological Relationships Between Heart Failure and Depression and Anxiety

Chapa

Akintade

Son

et al. 2014

Critical Care Nurse

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H eart failure is an epidemic with national and global implications. Compared with the situation in other cardiac diseases, the incidence and prevalence of heart failure continue to increase despite recent advancements in understanding and treatment. Increased survival after myocardial infarction, aging of the population, and increased incidence of diabetes are contributing factors. This article has been designated for CNE credit. A closed-book, multiple-choice examination follows this article, which tests your knowledge of the following objectives:1. Describe the biopsychosocial holistic model for cardiovascular health 2. Identify 2 neurohormonal pathways and their impact in heart failure 3. Identify nursing implications for heart failure, depression, and anxiety CNE Continuing Nursing EducationCover Depression and anxiety are common comorbid conditions in patients with heart failure. Patients with heart failure and depression have increased mortality. The association of anxiety with increased mortality in patients with heart failure is not established. The purpose of this article is to illustrate the similarities of the underlying pathophysiology of heart failure, depression, and anxiety by using the Biopsychosocial Holistic Model of Cardiovascular Health. Depression and anxiety affect biological processes of cardiovascular function in patients with heart failure by altering neurohormonal function via activation of the hypothalamic-pituitary-adrenal axis, autonomic dysregulation, and activation of cytokine cascades and platelets. Patients with heart failure and depression or anxiety may exhibit a continued cycle of heart failure progression, increased depression, and increased anxiety. Understanding the underlying pathophysiological relationships in patients with heart failure who experience comorbid depression and/or anxiety is critical in order to implement appropriate treatments, educate patients and caregivers, and educate other health professionals. (Critical Care Nurse. 2014;34[2]:14-25)

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“…In turn, both MDD and depressive symptoms have been associated with (a) a twofold increased risk of mortality and (b) increased morbidity and rehospitalisation post-MI (2-6). Although several literature reviews have concluded that there is evidence that various other psychological factors are related to prognosis in established coronary artery disease (CAD) (7)(8)(9), the importance of these factors is less well established. In addition, it is not known which symptoms are specific to post-MI distress and whether there are reliably identifiable subgroups of post-MI patients with different psychological symptom profiles.…”

Section: Introductionmentioning

confidence: 99%

Psychological symptom clusters, psychiatric comorbidity and poor self-reported health status following myocardial infarction

2007

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The Influence of Anxiety and Depression on Outcomes of Patients With Coronary Artery Disease

Cited by 268 publications

References 128 publications

Anxiety and Poor Social Support are Independently Associated With Adverse Outcomes in Patients With Mild Heart Failure

Anxiety and Poor Social Support are Independently Associated With Adverse Outcomes in Patients With Mild Heart Failure

Pathophysiological Relationships Between Heart Failure and Depression and Anxiety

Psychological symptom clusters, psychiatric comorbidity and poor self-reported health status following myocardial infarction

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