The Influence of Antibiotics on the Spread of Tumors of the Colon

Cohn, Isidore; Atik, M

doi:10.1097/00000658-196006000-00016

Cited by 60 publications

(7 citation statements)

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“…The methods of study were a combination of those used by Haverback and Smith,[1][2][3][4][5][6][7][8][9][10][11] The results confirm previous work from this laboratory on the The methods of study were a combination of those used by Haverback and Smith,[1][2][3][4][5][6][7][8][9][10][11] The results confirm previous work from this laboratory on the…”

supporting

confidence: 79%

Just Words

Gode¹

1965

JAMA

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supporting

confidence: 79%

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Gode¹

1965

JAMA

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“…This indicated that lack of bacterial flora increased the incidence of implantation tumor at the surgical suture line. Cohn and Atik (10) repeated Vink's work with better experimental plans and controls, and confirmed his data.…”

Section: Iatrogenic Implantationsupporting

confidence: 56%

Factors in the Dissemination of Cancer*, †

Cole¹,

Webb²

1963

J American Geriatrics Society

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“…The ability of malignant cells to get im planted on the suture line has been investi gated before [13,16,17]. but no study was reported where not only colon cancer cells were used, but also intraperitoneal metastasis was avoided.…”

Section: Discussionmentioning

confidence: 99%

Implantation on the Suture Material and Efficacy of Povidone-iodine Solution

et al. 1997

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Suture implantation of viable exfoliated tumour cells may be responsible for local recurrence of colorectal cancer. Using a colon cancer cell line, we obtained a suture implantation without intraperitoneal metastasis in about 80% of the control animals, when sacrificed on the 2nd postoperative week. The cytotoxic efficacy of povidone-iodine (PVP-I) was tested in vivo by a rat model with viable intracaecal tumour cells, and in vitro by trypan blue exclusion and the MTT assay. In vivo PVP-I at 5 % significantly reduced the incidence of tumour growth, while the product at 2.5% had a significant effect in only the monofilament polypropylene group. In an in vitro toxicity study, PVP-I higher than 0.16% was effective at killing almost all tumour cells. PVP-I had effective cytotoxicity in vivo and in vitro, being less cytotoxic in vivo than in vitro.

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The Influence of Antibiotics on the Spread of Tumors of the Colon

Cited by 60 publications

References 0 publications

Just Words

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Factors in the Dissemination of Cancer*, †

Implantation on the Suture Material and Efficacy of Povidone-iodine Solution

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