The influence of anaesthesia and surgery on the circadian rhythm of melatonin

Kärkelä, J.; Vakkuri, Olli; Kaukinen, S.; Wq, Huang; Pasanen, Matti

doi:10.1034/j.1399-6576.2002.460106.x

Cited by 98 publications

(111 citation statements)

References 32 publications

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“…Any alteration detected in the timing of circulating melatonin is therefore considered to reflect altered functioning of the suprachiamatic clock. However, in all these studies the role of surgery itself has not been excluded (for discussion, see eg Karkela et al, 2002). Using propofol, the present data supports our working hypothesis that general anesthesia per se alters daily temporal organization.…”

Section: Clinical Significancesupporting

confidence: 80%

“…Data from human studies have shown disturbances in the pattern of melatonin secretion following general anesthesia associated with surgery Karkela et al, 2002;Reber et al, 1998). Secretion of melatonin by the pineal gland is commonly used as a circadian phase marker (Cassone et al, 1993;Pevet, 2003).…”

Section: Clinical Significancementioning

confidence: 99%

“…Such alterations, however, have been observed when anesthesia was performed in conjunction with surgery. The role of surgery itself cannot be fully excluded (for discussion, see eg Karkela et al, 2002). Finally, from all these studies, it is still unclear if general anesthesia per se has a direct effect on brain regulation of circadian timing.…”

Section: Introductionmentioning

confidence: 99%

“…The induction of ether or ketamine anesthesia during the resting phase (light period) of rodents has been shown to alter the daily rhythms of heart rate, body temperature and locomotor activity in the days following (Prudian et al, 1997). In humans, anesthesia and surgery with operative stress delay the onset of nocturnal melatonin secretion during the first postsurgical evening, suggesting a phase shift in the circadian secretion of melatonin Karkela et al, 2002;Reber et al, 1998). Such alterations, however, have been observed when anesthesia was performed in conjunction with surgery.…”

Section: Introductionmentioning

confidence: 99%

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Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Challet

Gourmelen

Pévet

et al. 2006

Neuropsychopharmacol

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Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (72 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant resetting effect at other times of the day. Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock. Neuropsychopharmacology (2007) 32, 728-735.

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Section: Clinical Significancesupporting

confidence: 80%

Section: Clinical Significancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Challet

Gourmelen

Pévet

et al. 2006

Neuropsychopharmacol

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“…Human studies show alterations in melatonin levels after general anaesthesia and surgery (20)(21)(22). All of these studies discuss the effects of anaesthesia or pain related to surgery as the reason for sleep disorders or delirium.…”

Section: Discussionmentioning

confidence: 99%

Day-Time Isoflurane Administration Suppresses Circadian Gene Expressions in Both the Brain and a Peripheral Organ, Liver

Gökmen¹,

Barış²,

Öçmen³

et al. 2017

Turk J Anaesth Reanim

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Relative effects of age on implant integration in a rat model: A longitudinal in vivo microct study

Freitag

Günther

Eberli

et al. 2019

Journal Orthopaedic Research

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The effect of age on implant fixation in bone is not always considered during the design of preclinical models. The decision on animal's age is often related to practical or historical reasons, which ultimately may affect the reproducibility of results. This study aimed to quantify the effect of age by monitoring the fixation of contrast‐enhanced PEEK screws in rats, hypothesizing that the kinetics of fixation is impaired in older animals but that age effects are less severe than osteoporotic effects. The time course of implant fixation was investigated in healthy rats at 24, 40, and 60 weeks of age; and in ovariectomized rats. Implant fixation was monitored using in‐vivo microCT and dynamic histomorphometry during 1 month. The rats were euthanized 28 days post screw insertion. The data was analyzed both in absolute value and after normalization to baseline bone mass. In absolute terms, greater age had a detrimental effect on bone implant contact, bone fraction, implant stiffness, and bone remodeling but less than ovariectomy. Interestingly, once data was normalized to baseline bone mass this effect disappeared, suggesting that the physiologic response to implant placement was not affected by age. In conclusion, implant fixation kinetics is less affected by age than by baseline bone mass in this rat model. Animals of different ages can therefore be compared but data must be construed relatively to baseline bone mass and not in absolute terms. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1–12, 2018.

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The influence of anaesthesia and surgery on the circadian rhythm of melatonin

Abstract: Our findings suggest that anaesthesia in conjunction with surgery acutely disturbed the normal circadian rhythm of melatonin by delaying the onset of nocturnal melatonin secretion.

Cited by 98 publications

References 32 publications

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Day-Time Isoflurane Administration Suppresses Circadian Gene Expressions in Both the Brain and a Peripheral Organ, Liver

Relative effects of age on implant integration in a rat model: A longitudinal in vivo microct study

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