“…According to the amyloid cascade theory,
oligomers or amyloid fibrils are formed by the aggregation of
oligomers or amyloid fibrils, which are key components of
peptide and impair the function of neuronal cells [
8]. Many mathematical models have been presented to explain the development of
monomer synthesis or aggregation (see [
9, 16–18] and the references therein). Another hypothesis that has attracted a lot of attention, proposes that disturbance of calcium
homeostasis is crucial to AD pathogenesis [
19–21].…”