The Influence of Alcohol on Viral and Isoproterenol Cardiomyopathy

Morin, Y; Roy, Paul‐Emile; Mohiuddin, Syed M.; Taskar, Pranali

doi:10.1093/cvr/3.3.363

Cited by 10 publications

(3 citation statements)

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“…Morin et al [41]administered Coxsacki B virus to 48 mice. One half received laboratory chow and alcohol and the other half received laboratory chow and sweetened water.…”

Section: Genuine Alcoholic Cardiomyopathies: Symptomatic Typesmentioning

confidence: 99%

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The Alcoholic Cardiomyopathies – Genuine and Pseudo

Constant

1999

Cardiology

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Two types of genuine alcoholic cardiomyopathies can produce congestive heart failure, an acute fulminate hyperkinetic type with high cardiac output and a hypokinetic type with a low cardiac output, both of which respond to thiamine. When the chronic alcoholic develops a dilated cardiomyopathy with congestive heart failure without a history of significant malnutrition, then they do not respond to thiamine. This may be explained by a study in which mice given a myotropic virus plus alcohol developed more frequent and severe viral cardiomyopathies than those not fed alcohol. This suggests that a chronic dilated cardiomyopathy in an alcoholic may not be the direct result of the alcohol but secondary to a viral myocarditis. This suggests that the preferred terminology for a dilated cardiomyopathy in an alcoholic who does not respond to thiamine and good nutrition should simply be a dilated cardiomyopathy in an alcoholic. We should assume that the cardiomyopathy is possibly of viral etiology.

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“…Morin et al [41]administered Coxsacki B virus to 48 mice. One half received laboratory chow and alcohol and the other half received laboratory chow and sweetened water.…”

Section: Genuine Alcoholic Cardiomyopathies: Symptomatic Typesmentioning

confidence: 99%

“…Only 30% of the non-alcohol group had cardiac lesions (p = 0.02). The cardiac involvement in the mice that received the alcohol was not only more frequent but also more severe than in the non-alcohol group [41]. …”

Section: Genuine Alcoholic Cardiomyopathies: Symptomatic Typesmentioning

confidence: 99%

The Alcoholic Cardiomyopathies – Genuine and Pseudo

Constant

1999

Cardiology

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“…This may have to do with the susceptibility for infections due to a suppressed immune system in a compromised human host and also in experimental animal [85]. Ethanol can alter lymphocyte functions, inhibit neutrophil chemotaxis, and suppress the production of cytokines, which are involved in regulating acute inflammatory responses to infectious challenges [86–88].…”

Section: Alcohol and Myocarditismentioning

confidence: 99%

Alkoholische Kardiomyopathie

Maisch

2016

Herz

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The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person’s health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites. Historical examples of interest are the Munich beer heart and the Tübingen wine heart. Associated with chronic alcohol abuse but having different etiologies are beriberi heart disease (vitamin B1 deficiency) and cardiac cirrhosis as hyperdynamic cardiomyopathies, arsenic poising in the Manchester beer epidemic, and cobalt intoxication in Quebec beer drinker’s disease. Chronic heavy alcohol abuse will also increase blood pressure and cause a downregulation of the immune system that could lead to increased susceptibility to infections, which in turn could add to the development of heart failure. Myocardial tissue analysis resembles idiopathic cardiomyopathy or chronic myocarditis. In the diagnostic work-up of alcoholic cardiomyopathy, the confirmation of alcohol abuse by carbohydrate deficient transferrin (CDT) and increased liver enzymes, and the involvement of the heart by markers of heart failure (e.g., NT-proBNP) and of necrosis (e.g., troponins or CKMb) is mandatory. Treatment of alcoholic cardiomyopathy consists of alcohol abstinence and heart failure medication.

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Cardiovascular Effects of Alcohol

Frıedman

1998

Recent Developments in Alcoholism

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The Influence of Alcohol on Viral and Isoproterenol Cardiomyopathy

Cited by 10 publications

References 0 publications

The Alcoholic Cardiomyopathies – Genuine and Pseudo

The Alcoholic Cardiomyopathies – Genuine and Pseudo

Alkoholische Kardiomyopathie

Cardiovascular Effects of Alcohol

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